CP21R7_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the CP21R7_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.362763
TMSB10 thymosin beta 10 0.230668
FTH1 ferritin, heavy polypeptide 1 0.129175
AKAP12 A kinase (PRKA) anchor protein 12 0.114662
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.102771
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0974393
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0878054
IGFBP3 insulin-like growth factor binding protein 3 0.0864282
VIM vimentin 0.0850459
DOCK4 dedicator of cytokinesis 4 0.0831885
LDHA lactate dehydrogenase A 0.0783383
CXCL8 chemokine (C-X-C motif) ligand 8 0.0780747
PDE4D phosphodiesterase 4D, cAMP-specific 0.0726814
C15ORF48 chromosome 15 open reading frame 48 0.0687509
ASPH aspartate beta-hydroxylase 0.0627173
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.058019
STC1 stanniocalcin 1 0.057803
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.048209
TM4SF1 transmembrane 4 L six family member 1 0.0465714
BASP1 brain abundant, membrane attached signal protein 1 0.0448048
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.043234
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0423834
GLIS3 GLIS family zinc finger 3 0.0416864
PKM pyruvate kinase, muscle 0.0406086
RPLP1 ribosomal protein, large, P1 0.0402538
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0374169
FTL ferritin, light polypeptide 0.0371205
TIMP1 TIMP metallopeptidase inhibitor 1 0.0371045
ACTN1 actinin, alpha 1 0.0370161
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0365215
FAM107B family with sequence similarity 107, member B 0.0343859
THSD4 thrombospondin, type I, domain containing 4 0.0343468
RPL23 ribosomal protein L23 0.0339866
AHNAK AHNAK nucleoprotein 0.0330254
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.032023
LOC112694756 uncharaterized LOC112694756 0.0317657
UBASH3B ubiquitin associated and SH3 domain containing B 0.0316023
SNX14 sorting nexin 14 0.0307919
SPDYA speedy/RINGO cell cycle regulator family member A 0.0305994
INHBA inhibin, beta A 0.0297609
UTRN utrophin 0.0297219
S100A11 S100 calcium binding protein A11 0.0292389
IL6 interleukin 6 0.0292373
TPI1 triosephosphate isomerase 1 0.028483
GRAMD1B GRAM domain containing 1B 0.0284652
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0282932
HSPA8 heat shock 70kDa protein 8 0.0282095
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0271225
RPS19 ribosomal protein S19 0.0271074
NRG1 neuregulin 1 0.0269151
PFN1 profilin 1 0.0265516
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0261772
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0259445
ANGPTL4 angiopoietin-like 4 0.0255879
S100A6 S100 calcium binding protein A6 0.0255834
EEF2 eukaryotic translation elongation factor 2 0.02491
MCL1 myeloid cell leukemia 1 0.0245738
RPS4X ribosomal protein S4, X-linked 0.0244171
SOX4 SRY (sex determining region Y)-box 4 0.0243573
LAMC2 laminin, gamma 2 0.0239738
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0233064
OSMR oncostatin M receptor 0.0231966
S100A10 S100 calcium binding protein A10 0.0230755
B2M beta-2-microglobulin 0.0227002
STK17A serine/threonine kinase 17a 0.0226899
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0226254
KYNU kynureninase 0.0224396
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0224164
PYGL phosphorylase, glycogen, liver 0.0223609
NDRG1 N-myc downstream regulated 1 0.0223412
RPL36AL ribosomal protein L36a-like 0.0222832
FLNB filamin B, beta 0.0221436
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0220784
DSE dermatan sulfate epimerase 0.0219756
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0218844
CLIC1 chloride intracellular channel 1 0.0218365
LMAN1 lectin, mannose-binding, 1 0.0215899
DOCK5 dedicator of cytokinesis 5 0.0213282
POTEF POTE ankyrin domain family, member F 0.0211253
ENO1 enolase 1, (alpha) 0.0210091
FNDC3B fibronectin type III domain containing 3B 0.0209274
PRDX1 peroxiredoxin 1 0.0206393
FOS FBJ murine osteosarcoma viral oncogene homolog 0.020576
AGO2 argonaute RISC catalytic component 2 0.0205353
ALCAM activated leukocyte cell adhesion molecule 0.0204691
RPL12 ribosomal protein L12 0.0203544
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0203412
ATXN1 ataxin 1 0.0202509
CALU calumenin 0.0202229
ACTG1 actin gamma 1 0.020016
ANKRD12 ankyrin repeat domain 12 0.0198647
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.0197797
GRB10 growth factor receptor-bound protein 10 0.0197743
EIF4A1 eukaryotic translation initiation factor 4A1 0.0196563
IFITM3 interferon induced transmembrane protein 3 0.0195143
ATP5F1E ATP synthase F1 subunit epsilon 0.019404
ZFHX3 zinc finger homeobox 3 0.0193334
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0191415
SVIL supervillin 0.0191263
SH3KBP1 SH3-domain kinase binding protein 1 0.0190801

decreased expression

Symbol Name Standardized Value
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0674714
WDR43 WD repeat domain 43 -0.0641181
RBM39 RNA binding motif protein 39 -0.0596708
TXNRD1 thioredoxin reductase 1 -0.0555921
PM20D1 peptidase M20 domain containing 1 -0.0497255
NOP58 NOP58 ribonucleoprotein -0.0425422
RPS2 ribosomal protein S2 -0.0420602
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0405754
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.03933
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0389631
ZFAND3 zinc finger, AN1-type domain 3 -0.0382703
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0377607
PTMA prothymosin, alpha -0.0369445
CCNL1 cyclin L1 -0.0367626
PUM2 pumilio RNA-binding family member 2 -0.0361171
USP3 ubiquitin specific peptidase 3 -0.0354131
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0352956
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0345077
YBX3 Y box binding protein 3 -0.0335562
BCLAF1 BCL2-associated transcription factor 1 -0.0334797
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0334604
ECT2 epithelial cell transforming 2 -0.0323555
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0318434
MIS18BP1 MIS18 binding protein 1 -0.031836
PTK2 protein tyrosine kinase 2 -0.0317551
RTN4 reticulon 4 -0.0312817
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0312623
NCEH1 neutral cholesterol ester hydrolase 1 -0.0312165
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0306495
MATR3 matrin 3 -0.0299137
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0297765
KPNB1 karyopherin (importin) beta 1 -0.0297107
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0294918
CENPF centromere protein F, 350/400kDa -0.0292383
NAMPT nicotinamide phosphoribosyltransferase -0.0286685
TPX2 TPX2, microtubule-associated -0.0284286
TFPI2 tissue factor pathway inhibitor 2 -0.0279501
PAPOLA poly(A) polymerase alpha -0.0276682
WAC WW domain containing adaptor with coiled-coil -0.027664
OLA1 Obg-like ATPase 1 -0.0267978
SPAG9 sperm associated antigen 9 -0.0264095
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0264004
ADAM17 ADAM metallopeptidase domain 17 -0.0263765
MKI67 marker of proliferation Ki-67 -0.0259472
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0259244
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0257592
RPL37A ribosomal protein L37a -0.0256003
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0251357
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -0.02512
RPS12 ribosomal protein S12 -0.0248234
ANKRD11 ankyrin repeat domain 11 -0.0247054
DENND4A DENN/MADD domain containing 4A -0.0246934
NUP153 nucleoporin 153kDa -0.0244849
PUM1 pumilio RNA-binding family member 1 -0.0244327
CAMTA1 calmodulin binding transcription activator 1 -0.024217
RBM8A RNA binding motif protein 8A -0.0240716
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0240661
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0239419
ANLN anillin, actin binding protein -0.0238727
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0238664
RHEB Ras homolog enriched in brain -0.0238607
CYRIB CYFIP related Rac1 interactor B -0.0236497
MRTFA myocardin related transcription factor A -0.0236413
WTAP Wilms tumor 1 associated protein -0.0236178
HSPA4 heat shock 70kDa protein 4 -0.0235845
TRA2B transformer 2 beta homolog (Drosophila) -0.023491
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0230816
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0229757
TRA2A transformer 2 alpha homolog (Drosophila) -0.022862
HMGB2 high mobility group box 2 -0.0227724
NUP58 nucleoporin 58 -0.0227109
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0225366
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0223085
NCOR1 nuclear receptor corepressor 1 -0.0223059
EWSR1 EWS RNA-binding protein 1 -0.0222104
AHR aryl hydrocarbon receptor -0.0218576
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0216683
EIF4A2 eukaryotic translation initiation factor 4A2 -0.02137
MORF4L1 mortality factor 4 like 1 -0.0213463
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0213323
YME1L1 YME1-like 1 ATPase -0.0212467
BIRC2 baculoviral IAP repeat containing 2 -0.0212438
RBM33 RNA binding motif protein 33 -0.0211717
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -0.0211556
RFWD3 ring finger and WD repeat domain 3 -0.0210486
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0207815
ATAD2 ATPase family, AAA domain containing 2 -0.0205572
NEGR1 neuronal growth regulator 1 -0.0203578
FGB fibrinogen beta chain -0.0203062
ATP5F1B ATP synthase F1 subunit beta -0.0202535
NAP1L1 nucleosome assembly protein 1-like 1 -0.0201663
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0201298
GOLT1B golgi transport 1B -0.0200597
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.020027
AGFG1 ArfGAP with FG repeats 1 -0.0199752
RYBP RING1 and YY1 binding protein -0.019944
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0199108
TPM3 tropomyosin 3 -0.0198908
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0198541
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0197792