CP21R7_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the CP21R7_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.46975
ERRFI1 ERBB receptor feedback inhibitor 1 0.093842
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0893554
YBX3 Y box binding protein 3 0.0856305
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0833753
GRAMD1B GRAM domain containing 1B 0.0754558
THSD4 thrombospondin, type I, domain containing 4 0.0603484
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.055962
STC1 stanniocalcin 1 0.0477238
ACTG1 actin gamma 1 0.0447044
OSMR oncostatin M receptor 0.0439493
PDE4D phosphodiesterase 4D, cAMP-specific 0.0437499
DOCK5 dedicator of cytokinesis 5 0.0432144
MCL1 myeloid cell leukemia 1 0.0404838
AFF3 AF4/FMR2 family, member 3 0.0395381
ELL2 elongation factor, RNA polymerase II, 2 0.0392704
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0389404
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0378401
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0373664
TPM3 tropomyosin 3 0.0365001
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0349738
VCL vinculin 0.03456
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0345297
FMNL2 formin-like 2 0.0345003
HSPA8 heat shock 70kDa protein 8 0.0344799
HMGA2 high mobility group AT-hook 2 0.0340614
POTEF POTE ankyrin domain family, member F 0.0335785
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0334382
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0333748
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.033373
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0330539
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0328909
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0327163
PDLIM5 PDZ and LIM domain 5 0.0326259
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0325226
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0323521
KTN1 kinectin 1 (kinesin receptor) 0.0323018
MACF1 microtubule-actin crosslinking factor 1 0.0317048
ACTN1 actinin, alpha 1 0.0310283
ZSWIM6 zinc finger, SWIM-type containing 6 0.0309588
RIMS2 regulating synaptic membrane exocytosis 2 0.0308367
PDE10A phosphodiesterase 10A 0.0304445
IGF1R insulin-like growth factor 1 receptor 0.0303891
MYH9 myosin, heavy chain 9, non-muscle 0.0303126
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0300575
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0298856
EEF2 eukaryotic translation elongation factor 2 0.0297715
TM4SF1 transmembrane 4 L six family member 1 0.0285054
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0282664
WWTR1 WW domain containing transcription regulator 1 0.0281128
TPI1 triosephosphate isomerase 1 0.0280175
KRT18 keratin 18, type I 0.0279076
DST dystonin 0.0276095
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0266758
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0265561
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0263342
EXT1 exostosin glycosyltransferase 1 0.0257324
LOC102724023 ES1 protein homolog, mitochondrial 0.0251733
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.024916
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.02446
EIF4A1 eukaryotic translation initiation factor 4A1 0.0243808
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0242833
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0241857
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0237636
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0237252
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0231158
SVIL supervillin 0.0227761
EGFR epidermal growth factor receptor 0.0224546
RPS4X ribosomal protein S4, X-linked 0.0223655
PRH1 proline-rich protein HaeIII subfamily 1 0.0222244
NABP1 nucleic acid binding protein 1 0.0221299
TMSB10 thymosin beta 10 0.0217198
AEBP2 AE binding protein 2 0.0217101
FNDC3B fibronectin type III domain containing 3B 0.0216841
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0214866
RAD51B RAD51 paralog B 0.0214748
ATP11A ATPase, class VI, type 11A 0.0214336
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0213984
PRKCE protein kinase C, epsilon 0.0212108
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0206243
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0205909
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0202143
HOMER1 homer scaffolding protein 1 0.0201212
PARP14 poly (ADP-ribose) polymerase family, member 14 0.020026
EXOC4 exocyst complex component 4 0.0195286
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0194112
MCTP1 multiple C2 domains, transmembrane 1 0.0193117
BZW1 basic leucine zipper and W2 domains 1 0.0192132
MT2A metallothionein 2A 0.0191899
SYNE2 spectrin repeat containing, nuclear envelope 2 0.019044
EGR1 early growth response 1 0.0190409
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0189385
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0187548
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0186407
IFI6 interferon, alpha-inducible protein 6 0.018613
WWOX WW domain containing oxidoreductase 0.0184966
WNT2B wingless-type MMTV integration site family, member 2B 0.0182886
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0182597
SET SET nuclear proto-oncogene 0.0181817
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0180387

decreased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0372161
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0287524
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0265589
PHIP pleckstrin homology domain interacting protein -0.0252127
GOLGA4 golgin A4 -0.022312
WSB1 WD repeat and SOCS box containing 1 -0.0211218
UBE2H ubiquitin-conjugating enzyme E2H -0.0211094
KMT2E lysine (K)-specific methyltransferase 2E -0.0182639
GGNBP2 gametogenetin binding protein 2 -0.0180942
CENPE centromere protein E, 312kDa -0.016605
OGA O-GlcNAcase -0.0165973
MIS18BP1 MIS18 binding protein 1 -0.0163224
BBX bobby sox homolog (Drosophila) -0.0162176
SMC4 structural maintenance of chromosomes 4 -0.0161542
RPL37A ribosomal protein L37a -0.0159773
RPS29 ribosomal protein S29 -0.0159318
FTL ferritin, light polypeptide -0.0154923
TFG TRK-fused gene -0.0150303
CCNL1 cyclin L1 -0.0146684
ZNF292 zinc finger protein 292 -0.0146492
RPS25 ribosomal protein S25 -0.0145193
RBM39 RNA binding motif protein 39 -0.0142246
RPLP0 ribosomal protein, large, P0 -0.0141922
TNPO3 transportin 3 -0.0139055
RPL37 ribosomal protein L37 -0.0135716
PTEN phosphatase and tensin homolog -0.0133341
CEP95 centrosomal protein 95kDa -0.0133257
RTN4 reticulon 4 -0.0132202
RPS8 ribosomal protein S8 -0.01321
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0130135
EIF1 eukaryotic translation initiation factor 1 -0.01299
CAMKMT calmodulin-lysine N-methyltransferase -0.0127946
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0126881
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0122352
SBF2 SET binding factor 2 -0.0120424
WDPCP WD repeat containing planar cell polarity effector -0.0118888
ATP5F1B ATP synthase F1 subunit beta -0.0116532
TMEM165 transmembrane protein 165 -0.0116294
RNF38 ring finger protein 38 -0.0113358
HMGA1 high mobility group AT-hook 1 -0.0110196
XPO1 exportin 1 -0.0109752
PFN1 profilin 1 -0.010782
ADAM9 ADAM metallopeptidase domain 9 -0.0107355
SRBD1 S1 RNA binding domain 1 -0.0106435
WDR45B WD repeat domain 45B -0.0105798
RPL9 ribosomal protein L9 -0.0105603
RNMT RNA (guanine-7-) methyltransferase -0.0104532
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.010441
RPL35A ribosomal protein L35a -0.0103227
NOP58 NOP58 ribonucleoprotein -0.0103137
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0102861
THOC1 THO complex 1 -0.0101588
SRSF11 serine/arginine-rich splicing factor 11 -0.0101388
NEK7 NIMA-related kinase 7 -0.0101351
TBC1D23 TBC1 domain family, member 23 -0.0100224
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.00996753
ANKRD28 ankyrin repeat domain 28 -0.00994659
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.00990493
TBK1 TANK-binding kinase 1 -0.0098513
ZFR zinc finger RNA binding protein -0.00984072
KDM3A lysine (K)-specific demethylase 3A -0.00980991
RUSC2 RUN and SH3 domain containing 2 -0.0098098
RB1CC1 RB1-inducible coiled-coil 1 -0.00975037
MKI67 marker of proliferation Ki-67 -0.00971893
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.00966186
HM13 histocompatibility (minor) 13 -0.00962504
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.00957273
RPL23 ribosomal protein L23 -0.00951628
RPL13A ribosomal protein L13a -0.00951458
CKAP2 cytoskeleton associated protein 2 -0.00945414
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.00943045
PTMA prothymosin, alpha -0.00938417
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.00935062
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00931968
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.00929977
VDAC1 voltage-dependent anion channel 1 -0.0092671
PNISR PNN-interacting serine/arginine-rich protein -0.00920156
SINHCAF SIN3-HDAC complex associated factor -0.00919286
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0091587
RPL8 ribosomal protein L8 -0.00915313
TSC22D2 TSC22 domain family, member 2 -0.00914691
ARHGAP12 Rho GTPase activating protein 12 -0.00912623
NUP153 nucleoporin 153kDa -0.00904415
KIF18B kinesin family member 18B -0.00897762
PDIA3 protein disulfide isomerase family A, member 3 -0.00889749
RPS23 ribosomal protein S23 -0.00884792
ZMYM2 zinc finger, MYM-type 2 -0.00881582
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.00881204
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.00872505
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.00872399
APTX aprataxin -0.00864675
CAMTA1 calmodulin binding transcription activator 1 -0.00860672
GATAD2B GATA zinc finger domain containing 2B -0.00855747
SPPL3 signal peptide peptidase like 3 -0.00843788
RNF13 ring finger protein 13 -0.00842862
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.00836492
KCMF1 potassium channel modulatory factor 1 -0.00830816
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.00830737
TLK1 tousled-like kinase 1 -0.00828115
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.00824136