CP21R7_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the CP21R7_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.129191
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.122531
ACTG1 actin gamma 1 0.0938054
EXT1 exostosin glycosyltransferase 1 0.0937653
TMSB10 thymosin beta 10 0.0821287
ENO1 enolase 1, (alpha) 0.0804172
SOX4 SRY (sex determining region Y)-box 4 0.0773932
EFNA5 ephrin-A5 0.0757007
IGFBP3 insulin-like growth factor binding protein 3 0.072938
SAMD4A sterile alpha motif domain containing 4A 0.0678709
LPP LIM domain containing preferred translocation partner in lipoma 0.064883
FTH1 ferritin, heavy polypeptide 1 0.0623041
POTEF POTE ankyrin domain family, member F 0.0595673
LAMB3 laminin, beta 3 0.0525242
IFI27 interferon, alpha-inducible protein 27 0.0516249
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0505097
FBXO32 F-box protein 32 0.0463036
LIMCH1 LIM and calponin homology domains 1 0.045481
LDHA lactate dehydrogenase A 0.0454391
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0452854
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0452191
IFI16 interferon, gamma-inducible protein 16 0.0423722
ZFP36L1 ZFP36 ring finger protein-like 1 0.0392804
RPS4X ribosomal protein S4, X-linked 0.0382379
MAP1B microtubule-associated protein 1B 0.037808
MYO1E myosin IE 0.0377623
VEGFA vascular endothelial growth factor A 0.0375916
IFITM1 interferon induced transmembrane protein 1 0.0373565
EEF2 eukaryotic translation elongation factor 2 0.036731
KRT8 keratin 8, type II 0.035754
EIF1 eukaryotic translation initiation factor 1 0.0338076
VGLL3 vestigial-like family member 3 0.033028
PALLD palladin, cytoskeletal associated protein 0.0323801
BZW1 basic leucine zipper and W2 domains 1 0.0321244
EGFR epidermal growth factor receptor 0.0320789
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0316666
PLSCR1 phospholipid scramblase 1 0.0315442
KRT7 keratin 7, type II 0.0310241
MYH9 myosin, heavy chain 9, non-muscle 0.0304546
MX1 MX dynamin-like GTPase 1 0.0302287
RNF213 ring finger protein 213 0.0299096
NAV2 neuron navigator 2 0.0298764
LMO7 LIM domain 7 0.029338
SVIL supervillin 0.0289708
KDM2A lysine (K)-specific demethylase 2A 0.0289237
TXNIP thioredoxin interacting protein 0.0284925
DSPP dentin sialophosphoprotein 0.028383
ARHGAP20 Rho GTPase activating protein 20 0.0282948
CSTB cystatin B (stefin B) 0.0280967
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0280795
ETV6 ets variant 6 0.0280244
IFI6 interferon, alpha-inducible protein 6 0.0278729
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.027143
SP100 SP100 nuclear antigen 0.026973
SON SON DNA binding protein 0.0267381
TMEM165 transmembrane protein 165 0.0266661
SH3KBP1 SH3-domain kinase binding protein 1 0.0266042
TJP1 tight junction protein 1 0.0264231
TMSB4X thymosin beta 4, X-linked 0.0261445
ZSWIM6 zinc finger, SWIM-type containing 6 0.0258777
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0258179
ANKRD17 ankyrin repeat domain 17 0.0257078
RAP2B RAP2B, member of RAS oncogene family 0.0256031
LOC112694756 uncharaterized LOC112694756 0.0255971
BASP1 brain abundant, membrane attached signal protein 1 0.0249446
EGR1 early growth response 1 0.0248086
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0246351
ZBTB38 zinc finger and BTB domain containing 38 0.0245352
OSMR oncostatin M receptor 0.0241276
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0239792
KMT2C lysine (K)-specific methyltransferase 2C 0.0230881
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0227772
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0227445
RIGI RNA sensor RIG-I 0.0227176
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0227036
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.022592
F3 coagulation factor III (thromboplastin, tissue factor) 0.0225611
VCL vinculin 0.022546
IFITM3 interferon induced transmembrane protein 3 0.0224965
KRT18 keratin 18, type I 0.0222273
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.022175
ERBIN erbb2 interacting protein 0.0220013
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0219741
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0219097
CTBP2 C-terminal binding protein 2 0.0216897
RPL18 ribosomal protein L18 0.0215601
RSF1 remodeling and spacing factor 1 0.0214064
FOS FBJ murine osteosarcoma viral oncogene homolog 0.021207
SH3RF1 SH3 domain containing ring finger 1 0.0209145
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0209081
SEC31A SEC31 homolog A (S. cerevisiae) 0.0207792
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.020596
RAI14 retinoic acid induced 14 0.0205625
MYO6 myosin VI 0.0205588
RACK1 receptor for activated C kinase 1 0.0205245
JUP junction plakoglobin 0.0203214
ANO6 anoctamin 6 0.0202619
IRF7 interferon regulatory factor 7 0.0201297
CEP350 centrosomal protein 350kDa 0.020064
CD44 CD44 molecule (Indian blood group) 0.0199649

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.186127
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.185994
NAMPT nicotinamide phosphoribosyltransferase -0.129127
PTMA prothymosin, alpha -0.0950136
ELL2 elongation factor, RNA polymerase II, 2 -0.0854686
ASPH aspartate beta-hydroxylase -0.0823847
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0726367
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0672868
TSC22D2 TSC22 domain family, member 2 -0.0667904
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0638988
MARCHF6 membrane associated ring-CH-type finger 6 -0.0606172
TFG TRK-fused gene -0.058231
RNF145 ring finger protein 145 -0.054986
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0534554
RBM39 RNA binding motif protein 39 -0.0529296
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0527049
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0518917
PTK2 protein tyrosine kinase 2 -0.0494003
TPT1 tumor protein, translationally-controlled 1 -0.0455595
CDC73 cell division cycle 73 -0.0450047
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0435826
TXNRD1 thioredoxin reductase 1 -0.0424632
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0423708
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.042168
ZFAND3 zinc finger, AN1-type domain 3 -0.0416031
PAPOLA poly(A) polymerase alpha -0.0415438
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0414586
FN1 fibronectin 1 -0.0412117
ZNF292 zinc finger protein 292 -0.0409725
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0402665
CCNL1 cyclin L1 -0.0398156
RYBP RING1 and YY1 binding protein -0.0398028
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0396727
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0395785
UPP1 uridine phosphorylase 1 -0.0393938
RPL37A ribosomal protein L37a -0.0391368
RPS6 ribosomal protein S6 -0.0390301
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0387181
HMGB2 high mobility group box 2 -0.0386467
SLC38A1 solute carrier family 38, member 1 -0.0383426
USP3 ubiquitin specific peptidase 3 -0.0382001
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0378452
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0378078
RTN4 reticulon 4 -0.0374488
FNDC3B fibronectin type III domain containing 3B -0.0373699
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0365418
GOLGA4 golgin A4 -0.0362648
RLF rearranged L-myc fusion -0.0358809
BHLHE40 basic helix-loop-helix family, member e40 -0.0353827
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0352047
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0351739
RPL11 ribosomal protein L11 -0.0348604
KDM3A lysine (K)-specific demethylase 3A -0.0347972
TRA2A transformer 2 alpha homolog (Drosophila) -0.0347149
UBC ubiquitin C -0.0344779
SPAG9 sperm associated antigen 9 -0.0343819
MSMO1 methylsterol monooxygenase 1 -0.0340739
NCKAP1 NCK-associated protein 1 -0.0333984
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0326812
SSBP2 single-stranded DNA binding protein 2 -0.0323401
CLINT1 clathrin interactor 1 -0.0322325
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0320189
RYK receptor-like tyrosine kinase -0.0318866
GARS1 glycyl-tRNA synthetase 1 -0.0318247
MATR3 matrin 3 -0.031717
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0315036
DSTN destrin (actin depolymerizing factor) -0.0313017
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.031081
NAP1L1 nucleosome assembly protein 1-like 1 -0.0308711
TRA2B transformer 2 beta homolog (Drosophila) -0.0302182
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0301538
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0299579
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0298983
RASA2 RAS p21 protein activator 2 -0.0296069
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0295585
QKI QKI, KH domain containing, RNA binding -0.0295267
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0293079
TPR translocated promoter region, nuclear basket protein -0.028919
ADAM9 ADAM metallopeptidase domain 9 -0.0288328
KMT2E lysine (K)-specific methyltransferase 2E -0.028581
RPS29 ribosomal protein S29 -0.0285634
YTHDC1 YTH domain containing 1 -0.028543
TM4SF1 transmembrane 4 L six family member 1 -0.0284918
RPS2 ribosomal protein S2 -0.0281981
NUP58 nucleoporin 58 -0.0281083
MEF2A myocyte enhancer factor 2A -0.0280724
SLMAP sarcolemma associated protein -0.0279211
CANX calnexin -0.0278008
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0277795
EZR ezrin -0.0275995
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0275012
KDM6A lysine (K)-specific demethylase 6A -0.0273741
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0270784
CDK17 cyclin-dependent kinase 17 -0.026924
FIP1L1 factor interacting with PAPOLA and CPSF1 -0.0267389
FAM13A family with sequence similarity 13, member A -0.0265231
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0265139
WDR36 WD repeat domain 36 -0.026339
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0262537
NEK7 NIMA-related kinase 7 -0.0259949