CP21R7_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the CP21R7_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0948685
MCL1 myeloid cell leukemia 1 0.0826939
RPS4X ribosomal protein S4, X-linked 0.0659551
RPS23 ribosomal protein S23 0.0591129
TPT1 tumor protein, translationally-controlled 1 0.0586769
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0560877
LDHA lactate dehydrogenase A 0.0546218
ASPH aspartate beta-hydroxylase 0.0545672
EEF2 eukaryotic translation elongation factor 2 0.0532868
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0500594
RPS13 ribosomal protein S13 0.049947
PKM pyruvate kinase, muscle 0.0495168
HSPA8 heat shock 70kDa protein 8 0.0490278
POTEF POTE ankyrin domain family, member F 0.0490206
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.045783
RPL31 ribosomal protein L31 0.043716
RPL36A ribosomal protein L36a 0.0428292
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0425136
ESYT2 extended synaptotagmin-like protein 2 0.0414822
VIM vimentin 0.0398824
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.039372
GRAMD1B GRAM domain containing 1B 0.0391329
CTSL cathepsin L 0.0391155
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0365817
KYNU kynureninase 0.0360373
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.034855
NDRG1 N-myc downstream regulated 1 0.0344241
LOC112694756 uncharaterized LOC112694756 0.0342933
AKAP12 A kinase (PRKA) anchor protein 12 0.0334896
EIF1 eukaryotic translation initiation factor 1 0.0330908
RPL37 ribosomal protein L37 0.0322963
RPL3 ribosomal protein L3 0.0319711
EZR ezrin 0.031947
PDLIM5 PDZ and LIM domain 5 0.0319434
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0315917
PCBP2 poly(rC) binding protein 2 0.0315512
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0313311
CREB5 cAMP responsive element binding protein 5 0.0307062
RPL26 ribosomal protein L26 0.0307012
PRKCE protein kinase C, epsilon 0.0299917
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0277958
NCAM1 neural cell adhesion molecule 1 0.0271735
RPS21 ribosomal protein S21 0.0264751
RPS19 ribosomal protein S19 0.026397
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0263422
DOCK4 dedicator of cytokinesis 4 0.0263204
ATXN1 ataxin 1 0.02616
CXCL8 chemokine (C-X-C motif) ligand 8 0.0261278
ERRFI1 ERBB receptor feedback inhibitor 1 0.0256127
RPS24 ribosomal protein S24 0.0254901
RPL34 ribosomal protein L34 0.0246776
PRKN parkin RBR E3 ubiquitin protein ligase 0.0245981
TPI1 triosephosphate isomerase 1 0.0245025
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0238923
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0236953
RPLP2 ribosomal protein, large, P2 0.0236517
MCTP1 multiple C2 domains, transmembrane 1 0.0235037
MACF1 microtubule-actin crosslinking factor 1 0.0233865
ADNP activity-dependent neuroprotector homeobox 0.0231273
TXNIP thioredoxin interacting protein 0.0231257
FAT1 FAT atypical cadherin 1 0.0227754
RPL23 ribosomal protein L23 0.0224793
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0221418
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0218538
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.021846
MSN moesin 0.0218372
ZEB2 zinc finger E-box binding homeobox 2 0.0218114
RAD51B RAD51 paralog B 0.0217224
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0212914
IQGAP1 IQ motif containing GTPase activating protein 1 0.0212836
NRXN3 neurexin 3 0.0212364
CLMN calmin (calponin-like, transmembrane) 0.0211708
RPS20 ribosomal protein S20 0.0209244
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0207509
EIF4A1 eukaryotic translation initiation factor 4A1 0.0205847
RPL32 ribosomal protein L32 0.02055
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0204766
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0203737
ZBTB20 zinc finger and BTB domain containing 20 0.0196477
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.018857
FNDC3B fibronectin type III domain containing 3B 0.0184667
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0184603
RPL21 ribosomal protein L21 0.0184544
RPS18 ribosomal protein S18 0.0183707
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0183252
LOC102724023 ES1 protein homolog, mitochondrial 0.0182849
NUMB numb homolog (Drosophila) 0.0181506
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0179193
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0177766
RPL29 ribosomal protein L29 0.0176637
RPS29 ribosomal protein S29 0.0176345
RERE arginine-glutamic acid dipeptide (RE) repeats 0.017583
RPL11 ribosomal protein L11 0.0175337
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0175311
TNPO3 transportin 3 0.0174564
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0170861
RPL38 ribosomal protein L38 0.0170326
RPS11 ribosomal protein S11 0.0170049
RPL15 ribosomal protein L15 0.0169393
CD44 CD44 molecule (Indian blood group) 0.0168386

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.182736
NALF1 NALCN channel auxiliary factor 1 -0.146749
FN1 fibronectin 1 -0.146035
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.116989
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.116938
PDE4D phosphodiesterase 4D, cAMP-specific -0.106427
SMYD3 SET and MYND domain containing 3 -0.084452
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0755579
CANX calnexin -0.0726889
COL5A2 collagen, type V, alpha 2 -0.0724216
FTL ferritin, light polypeptide -0.0662866
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0600898
PSD3 pleckstrin and Sec7 domain containing 3 -0.0599244
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0554716
DST dystonin -0.0544009
P3H2 prolyl 3-hydroxylase 2 -0.0484978
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0473133
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0468627
CDH13 cadherin 13 -0.0463808
PTMA prothymosin, alpha -0.0454244
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0452995
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0448044
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0412468
LIMCH1 LIM and calponin homology domains 1 -0.038904
MYOF myoferlin -0.0387009
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.03829
PDIA3 protein disulfide isomerase family A, member 3 -0.0381816
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0377809
VCL vinculin -0.03777
RGS2 regulator of G-protein signaling 2 -0.0363806
NCOA7 nuclear receptor coactivator 7 -0.0361
TBXT T-box transcription factor T -0.0355929
TMX4 thioredoxin-related transmembrane protein 4 -0.0350898
LMAN1 lectin, mannose-binding, 1 -0.0343725
NCKAP5 NCK-associated protein 5 -0.034235
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0342103
GDA guanine deaminase -0.033735
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0327903
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.032024
MARCHF1 membrane associated ring-CH-type finger 1 -0.0315973
PTPRD protein tyrosine phosphatase, receptor type, D -0.0311575
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0311563
TXNRD1 thioredoxin reductase 1 -0.030235
PTEN phosphatase and tensin homolog -0.0302162
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0301602
PBX1 pre-B-cell leukemia homeobox 1 -0.0297953
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0297263
PDE7B phosphodiesterase 7B -0.0292269
KIAA0825 KIAA0825 -0.0282736
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0274677
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0272655
SPAG9 sperm associated antigen 9 -0.0271897
TM4SF1 transmembrane 4 L six family member 1 -0.0265705
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0263334
WARS1 tryptophanyl-tRNA synthetase 1 -0.0258785
ADGRB3 adhesion G protein-coupled receptor B3 -0.0257565
GREM2 gremlin 2, DAN family BMP antagonist -0.0256295
GNAS GNAS complex locus -0.0255638
LAMA1 laminin, alpha 1 -0.0253022
EPHA5 EPH receptor A5 -0.0247523
SLC16A6 solute carrier family 16, member 6 -0.0244505
SAMD4A sterile alpha motif domain containing 4A -0.024378
S100A6 S100 calcium binding protein A6 -0.0242508
CUX1 cut-like homeobox 1 -0.0238869
BZW1 basic leucine zipper and W2 domains 1 -0.0237849
SEC31A SEC31 homolog A (S. cerevisiae) -0.0231882
FNDC3A fibronectin type III domain containing 3A -0.0231441
AHNAK AHNAK nucleoprotein -0.0230805
MON2 MON2 homolog (S. cerevisiae) -0.0229185
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0225766
MORF4L2 mortality factor 4 like 2 -0.0223578
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0220709
RTN1 reticulon 1 -0.0220498
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0220193
PALLD palladin, cytoskeletal associated protein -0.0219973
MATR3 matrin 3 -0.0215702
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0214493
NCOR1 nuclear receptor corepressor 1 -0.0214328
COL4A6 collagen, type IV, alpha 6 -0.0213431
LSAMP limbic system-associated membrane protein -0.0211352
PTPRM protein tyrosine phosphatase, receptor type, M -0.0211081
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0207558
TRIO trio Rho guanine nucleotide exchange factor -0.0205514
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0203812
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0203047
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0202171
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0196877
IFI16 interferon, gamma-inducible protein 16 -0.0196698
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.019666
TMSB4X thymosin beta 4, X-linked -0.0194642
CADM2 cell adhesion molecule 2 -0.0194633
CENPF centromere protein F, 350/400kDa -0.0193451
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0192964
ESM1 endothelial cell-specific molecule 1 -0.0192669
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0191242
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0190169
EFNA5 ephrin-A5 -0.0190161
KDM3A lysine (K)-specific demethylase 3A -0.0189852
BCAS3 breast carcinoma amplified sequence 3 -0.0188764
PCDH15 protocadherin-related 15 -0.0188619