CP21R7_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

163 genes differentially expressed following the CP21R7_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.249611
IGFBP5 insulin-like growth factor binding protein 5 0.11676
GPC6 glypican 6 0.109382
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.102555
ENO1 enolase 1, (alpha) 0.0975365
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0835594
PGK1 phosphoglycerate kinase 1 0.0831656
ASPH aspartate beta-hydroxylase 0.076082
PKM pyruvate kinase, muscle 0.0679582
SBF2 SET binding factor 2 0.0665065
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0664851
COL5A2 collagen, type V, alpha 2 0.0660737
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0636639
FTL ferritin, light polypeptide 0.0627694
LDHA lactate dehydrogenase A 0.0606633
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0603137
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0583607
EEF2 eukaryotic translation elongation factor 2 0.0549137
NPAS2 neuronal PAS domain protein 2 0.0547399
LMO7 LIM domain 7 0.0539929
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0527457
MAML3 mastermind-like 3 (Drosophila) 0.0484193
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0473413
PDE10A phosphodiesterase 10A 0.0472212
POTEF POTE ankyrin domain family, member F 0.0459299
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0457091
NALF1 NALCN channel auxiliary factor 1 0.042759
KDM5B lysine (K)-specific demethylase 5B 0.0414286
SMYD3 SET and MYND domain containing 3 0.0403383
EZR ezrin 0.035014
ZFAND3 zinc finger, AN1-type domain 3 0.0349809
B2M beta-2-microglobulin 0.0346397
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0284229
DSCAM Down syndrome cell adhesion molecule 0.0281617
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0277262
PSD3 pleckstrin and Sec7 domain containing 3 0.0273281
TXNRD1 thioredoxin reductase 1 0.0260543
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0259466
VCL vinculin 0.0257776
RPS3 ribosomal protein S3 0.0249983
MBNL1 muscleblind-like splicing regulator 1 0.0242555
MON2 MON2 homolog (S. cerevisiae) 0.0234431
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0210506
ACTG1 actin gamma 1 0.0209333
LPP LIM domain containing preferred translocation partner in lipoma 0.0207001
IGF2 insulin-like growth factor 2 0.0206008
MEF2A myocyte enhancer factor 2A 0.020243
RPS12 ribosomal protein S12 0.0197539
FNDC3A fibronectin type III domain containing 3A 0.0179503
SRPK2 SRSF protein kinase 2 0.0179392
ATXN1 ataxin 1 0.0161326
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0143639
SPAG9 sperm associated antigen 9 0.0141669
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0130762
GMDS GDP-mannose 4,6-dehydratase 0.0123631
PTPRK protein tyrosine phosphatase, receptor type, K 0.0121124
IGFBP3 insulin-like growth factor binding protein 3 0.0113849
KMT2E lysine (K)-specific methyltransferase 2E 0.0112655
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.00976086
OGA O-GlcNAcase 0.0097459
MYOF myoferlin 0.00914367
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.00800697
RPS4X ribosomal protein S4, X-linked 0.00784959
DOCK5 dedicator of cytokinesis 5 0.00710423
MBD5 methyl-CpG binding domain protein 5 0.00680493
TPM4 tropomyosin 4 0.00547598
JMJD1C jumonji domain containing 1C 0.00498983
DST dystonin 0.00470854
RPL35A ribosomal protein L35a 0.00430147
RPL26 ribosomal protein L26 0.00270809
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.00232633
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.00187332
PRELID2 PRELI domain containing 2 0.00121719

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.111383
ALCAM activated leukocyte cell adhesion molecule -0.104114
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0973809
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0860112
VIM vimentin -0.0802542
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0777106
CDH13 cadherin 13 -0.0750685
CANX calnexin -0.0657882
TMSB10 thymosin beta 10 -0.0657469
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0649146
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0641125
HMGA2 high mobility group AT-hook 2 -0.0636284
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.062221
KMT2C lysine (K)-specific methyltransferase 2C -0.0597251
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0580737
SLTM SAFB-like, transcription modulator -0.0572555
NBEAL1 neurobeachin-like 1 -0.0568469
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0563932
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0549655
MYO1E myosin IE -0.0519018
PDE4D phosphodiesterase 4D, cAMP-specific -0.0512184
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0497774
PRKD3 protein kinase D3 -0.0482473
EIF1 eukaryotic translation initiation factor 1 -0.0476042
LAMA4 laminin, alpha 4 -0.0474522
GRB10 growth factor receptor-bound protein 10 -0.0468839
SAMD4A sterile alpha motif domain containing 4A -0.0455947
TTC3 tetratricopeptide repeat domain 3 -0.0453601
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0448307
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0441141
EGFR epidermal growth factor receptor -0.0434247
TRIO trio Rho guanine nucleotide exchange factor -0.040813
AKAP13 A kinase (PRKA) anchor protein 13 -0.0398746
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0395239
PRKCA protein kinase C, alpha -0.0384776
THSD4 thrombospondin, type I, domain containing 4 -0.0365902
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0346908
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0343521
EFNA5 ephrin-A5 -0.0334313
RORA RAR-related orphan receptor A -0.0321792
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0315375
PARD3 par-3 family cell polarity regulator -0.029845
TAS2R14 taste receptor, type 2, member 14 -0.0289832
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0284067
DOCK4 dedicator of cytokinesis 4 -0.0278795
APP amyloid beta (A4) precursor protein -0.0275625
ZBTB20 zinc finger and BTB domain containing 20 -0.0275573
MARCHF7 membrane associated ring-CH-type finger 7 -0.0270398
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0263041
FLNB filamin B, beta -0.0257092
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0249573
PDLIM5 PDZ and LIM domain 5 -0.0240241
ANXA2 annexin A2 -0.0235631
TCF12 transcription factor 12 -0.0220049
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0218728
SETD5 SET domain containing 5 -0.0217665
RPL31 ribosomal protein L31 -0.021322
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0204116
ESYT2 extended synaptotagmin-like protein 2 -0.0202347
SMAD3 SMAD family member 3 -0.020156
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0196751
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.019269
PRRC2C proline-rich coiled-coil 2C -0.0188059
KDM2A lysine (K)-specific demethylase 2A -0.018032
AKAP12 A kinase (PRKA) anchor protein 12 -0.0173368
BBX bobby sox homolog (Drosophila) -0.0172207
SNX9 sorting nexin 9 -0.0169234
PTMA prothymosin, alpha -0.0163732
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0161512
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0145616
SEC31A SEC31 homolog A (S. cerevisiae) -0.0134235
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0112432
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0105795
ATP9B ATPase, class II, type 9B -0.0105678
RPS6 ribosomal protein S6 -0.0102666
AOPEP aminopeptidase O (putative) -0.0100599
RIGI RNA sensor RIG-I -0.00743254
NDRG1 N-myc downstream regulated 1 -0.00702162
COL8A1 collagen, type VIII, alpha 1 -0.00671763
PTK2 protein tyrosine kinase 2 -0.00661988
LAMB3 laminin, beta 3 -0.00609849
FNDC3B fibronectin type III domain containing 3B -0.00581473
RUNX1 runt-related transcription factor 1 -0.00549782
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.00520259
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0049583
EXT1 exostosin glycosyltransferase 1 -0.00353875
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.00342593
CHD9 chromodomain helicase DNA binding protein 9 -0.00285492
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.00233109
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -2.48243E-4