CP21R7_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the CP21R7_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) 0.146434
AKAP12 A kinase (PRKA) anchor protein 12 0.112046
VCAN versican 0.090632
HDAC9 histone deacetylase 9 0.0884474
HMGA2 high mobility group AT-hook 2 0.0807554
VEGFA vascular endothelial growth factor A 0.0791709
NAV2 neuron navigator 2 0.0791238
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0731133
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0708439
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0692822
MT2A metallothionein 2A 0.0681416
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.067221
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0614964
STC1 stanniocalcin 1 0.0600259
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0594926
ZBTB38 zinc finger and BTB domain containing 38 0.0510657
TRIO trio Rho guanine nucleotide exchange factor 0.049346
ASPH aspartate beta-hydroxylase 0.049045
GLIS3 GLIS family zinc finger 3 0.0480191
LDHA lactate dehydrogenase A 0.0478675
FMNL2 formin-like 2 0.0475152
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0460878
RND3 Rho family GTPase 3 0.0434598
PPARD peroxisome proliferator-activated receptor delta 0.0434442
ZMIZ1 zinc finger, MIZ-type containing 1 0.0423461
KYNU kynureninase 0.0411502
MSN moesin 0.0406792
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0405747
NT5E 5'-nucleotidase, ecto (CD73) 0.0372465
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0364311
FN1 fibronectin 1 0.0357058
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0354285
ZSWIM6 zinc finger, SWIM-type containing 6 0.0341464
CDH13 cadherin 13 0.0338954
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0333236
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0324672
MACF1 microtubule-actin crosslinking factor 1 0.0324175
MYH9 myosin, heavy chain 9, non-muscle 0.0319413
RPS4X ribosomal protein S4, X-linked 0.0308001
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0306843
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0306326
TUT7 terminal uridylyl transferase 7 0.0303688
EEF2 eukaryotic translation elongation factor 2 0.0301645
SOX9 SRY (sex determining region Y)-box 9 0.0300753
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0297953
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0297758
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0277683
EFNA5 ephrin-A5 0.027061
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0270013
FTH1 ferritin, heavy polypeptide 1 0.0264667
GPC6 glypican 6 0.026089
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0259528
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0256357
IRAK2 interleukin-1 receptor-associated kinase 2 0.0255983
FNIP1 folliculin interacting protein 1 0.0254945
WWTR1 WW domain containing transcription regulator 1 0.0254355
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0249838
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.024954
ENO1 enolase 1, (alpha) 0.0249355
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0248751
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0243975
ZHX2 zinc fingers and homeoboxes 2 0.0243125
HMGA1 high mobility group AT-hook 1 0.0240987
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0233659
COL6A3 collagen, type VI, alpha 3 0.0230016
TLN1 talin 1 0.022926
SOD2 superoxide dismutase 2, mitochondrial 0.022908
SQSTM1 sequestosome 1 0.0228971
IGFBP3 insulin-like growth factor binding protein 3 0.0228253
NDRG1 N-myc downstream regulated 1 0.0227674
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.022683
SFRP1 secreted frizzled-related protein 1 0.0226642
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0225071
FAM107B family with sequence similarity 107, member B 0.0224835
TGM2 transglutaminase 2 0.0224083
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0223646
IQGAP1 IQ motif containing GTPase activating protein 1 0.0220773
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0220283
ERRFI1 ERBB receptor feedback inhibitor 1 0.0219672
BACE2 beta-site APP-cleaving enzyme 2 0.0215815
ZNF292 zinc finger protein 292 0.0212062
TNIP1 TNFAIP3 interacting protein 1 0.0210724
ICAM1 intercellular adhesion molecule 1 0.0206932
INTS6 integrator complex subunit 6 0.0206311
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0205807
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 0.0205183
IFI16 interferon, gamma-inducible protein 16 0.0201962
JMJD1C jumonji domain containing 1C 0.0200336
ZFP36L1 ZFP36 ring finger protein-like 1 0.0200175
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0199479
RB1CC1 RB1-inducible coiled-coil 1 0.019858
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0195713
ACTN1 actinin, alpha 1 0.0195397
ANXA1 annexin A1 0.0195141
SFTPA2 surfactant protein A2 0.0189924
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0187495
FHL2 four and a half LIM domains 2 0.0186959
PGM3 phosphoglucomutase 3 0.0184864
HSPA8 heat shock 70kDa protein 8 0.0183114
RIGI RNA sensor RIG-I 0.0182785

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.0881553
HLA-B major histocompatibility complex, class I, B -0.0761932
PTMA prothymosin, alpha -0.0658215
NAMPT nicotinamide phosphoribosyltransferase -0.0574287
RPS12 ribosomal protein S12 -0.0570255
RPL37A ribosomal protein L37a -0.0559983
TPT1 tumor protein, translationally-controlled 1 -0.0520387
COL1A1 collagen, type I, alpha 1 -0.0510558
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0507022
FTL ferritin, light polypeptide -0.0481905
RPS3 ribosomal protein S3 -0.0476463
TGFBI transforming growth factor, beta-induced, 68kDa -0.046255
UGCG UDP-glucose ceramide glucosyltransferase -0.0450246
EXT1 exostosin glycosyltransferase 1 -0.0431967
ACTG1 actin gamma 1 -0.0424892
TPM4 tropomyosin 4 -0.0407898
WSB1 WD repeat and SOCS box containing 1 -0.0400592
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0399979
ZMYND8 zinc finger, MYND-type containing 8 -0.0370547
RPL19 ribosomal protein L19 -0.0358579
RPL35A ribosomal protein L35a -0.0338121
BICC1 BicC family RNA binding protein 1 -0.0336807
IER3 immediate early response 3 -0.0334173
RPLP2 ribosomal protein, large, P2 -0.0317455
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0309646
THBS1 thrombospondin 1 -0.0309396
DLG1 discs, large homolog 1 (Drosophila) -0.0303801
SBF2 SET binding factor 2 -0.0298096
RPS24 ribosomal protein S24 -0.0287338
RPS23 ribosomal protein S23 -0.0276072
TENM2 teneurin transmembrane protein 2 -0.0270896
CTSD cathepsin D -0.0267469
RPL13A ribosomal protein L13a -0.0267281
RPL7A ribosomal protein L7a -0.0267226
KDM3A lysine (K)-specific demethylase 3A -0.0261551
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.025691
LRRC7 leucine rich repeat containing 7 -0.0250392
RPS29 ribosomal protein S29 -0.0243948
CADM1 cell adhesion molecule 1 -0.0243416
RPL37 ribosomal protein L37 -0.0240705
RPL38 ribosomal protein L38 -0.0240349
RPL11 ribosomal protein L11 -0.0239268
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0234525
RPS27A ribosomal protein S27a -0.0232053
RPL9 ribosomal protein L9 -0.022661
HLA-A major histocompatibility complex, class I, A -0.0222806
RPL31 ribosomal protein L31 -0.02193
RPL36A ribosomal protein L36a -0.0216505
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0216426
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0214441
ISG15 ISG15 ubiquitin-like modifier -0.0211663
CAVIN1 caveolae associated protein 1 -0.0209373
COL1A2 collagen, type I, alpha 2 -0.0207392
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0207169
AHNAK AHNAK nucleoprotein -0.0199872
TMSB10 thymosin beta 10 -0.0198401
RPS11 ribosomal protein S11 -0.0196258
CALD1 caldesmon 1 -0.0194246
DPYD dihydropyrimidine dehydrogenase -0.0193621
MYOF myoferlin -0.0190398
NAP1L1 nucleosome assembly protein 1-like 1 -0.0188789
RTN4 reticulon 4 -0.0186264
PLPP6 phospholipid phosphatase 6 -0.0185647
RUNX2 runt-related transcription factor 2 -0.0181809
TUBB tubulin, beta class I -0.0179243
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0178642
KMT2C lysine (K)-specific methyltransferase 2C -0.0177636
ZFAND3 zinc finger, AN1-type domain 3 -0.017732
EIF1 eukaryotic translation initiation factor 1 -0.0177126
NPEPPS aminopeptidase puromycin sensitive -0.0176306
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0176213
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0175262
CUX1 cut-like homeobox 1 -0.0172539
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0167966
SETD5 SET domain containing 5 -0.0167315
RPLP1 ribosomal protein, large, P1 -0.016695
XAF1 XIAP associated factor 1 -0.0166938
IFITM3 interferon induced transmembrane protein 3 -0.0162589
CHD9 chromodomain helicase DNA binding protein 9 -0.0162377
RPS19 ribosomal protein S19 -0.0160896
BIRC6 baculoviral IAP repeat containing 6 -0.0160497
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0155872
TPM1 tropomyosin 1 (alpha) -0.0155767
LPP LIM domain containing preferred translocation partner in lipoma -0.015354
ADNP activity-dependent neuroprotector homeobox -0.0152515
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0152456
RPS13 ribosomal protein S13 -0.0152357
MBD5 methyl-CpG binding domain protein 5 -0.0151486
PHF21A PHD finger protein 21A -0.0148896
NXN nucleoredoxin -0.014867
PALLD palladin, cytoskeletal associated protein -0.0148005
PTPRF protein tyrosine phosphatase, receptor type, F -0.0147734
FLNB filamin B, beta -0.0146733
KPNB1 karyopherin (importin) beta 1 -0.0146708
CFB complement factor B -0.0144774
RPL30 ribosomal protein L30 -0.0144325
RPS25 ribosomal protein S25 -0.0143756
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0143683
GGNBP2 gametogenetin binding protein 2 -0.0143281
IFI6 interferon, alpha-inducible protein 6 -0.0142655