CP21R7_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the CP21R7_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.132234
LDHA lactate dehydrogenase A 0.100884
VIM vimentin 0.0925784
CD44 CD44 molecule (Indian blood group) 0.0915794
PKM pyruvate kinase, muscle 0.0882739
TMSB10 thymosin beta 10 0.0796163
LOC112694756 uncharaterized LOC112694756 0.0778121
PTMA prothymosin, alpha 0.0730155
AKAP12 A kinase (PRKA) anchor protein 12 0.0668474
ENO1 enolase 1, (alpha) 0.0646868
MT2A metallothionein 2A 0.0571689
ANXA1 annexin A1 0.0556392
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0543952
BASP1 brain abundant, membrane attached signal protein 1 0.0514733
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0511323
RPS12 ribosomal protein S12 0.0484364
TXNIP thioredoxin interacting protein 0.0480282
RPS3 ribosomal protein S3 0.0457004
B2M beta-2-microglobulin 0.0451997
FTH1 ferritin, heavy polypeptide 1 0.0444967
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.043581
ZMYND8 zinc finger, MYND-type containing 8 0.0432654
DNER delta/notch-like EGF repeat containing 0.0431082
IGF2 insulin-like growth factor 2 0.0420662
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0416417
YBX3 Y box binding protein 3 0.0413119
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0409394
RPL23 ribosomal protein L23 0.0404647
ERRFI1 ERBB receptor feedback inhibitor 1 0.0403269
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0393675
POTEF POTE ankyrin domain family, member F 0.0392066
EEF2 eukaryotic translation elongation factor 2 0.0389295
RPL12 ribosomal protein L12 0.0377754
HILPDA hypoxia inducible lipid droplet-associated 0.0368004
NAMPT nicotinamide phosphoribosyltransferase 0.0349908
CLIP1 CAP-GLY domain containing linker protein 1 0.0347906
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0345587
RPS17 ribosomal protein S17 0.0344764
KTN1 kinectin 1 (kinesin receptor) 0.0343587
MED13 mediator complex subunit 13 0.0340721
EIF1 eukaryotic translation initiation factor 1 0.0335481
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0326504
APLP2 amyloid beta (A4) precursor-like protein 2 0.0321721
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0317444
FTL ferritin, light polypeptide 0.0317013
ASPH aspartate beta-hydroxylase 0.031175
RPL15 ribosomal protein L15 0.0307705
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0305054
HLA-B major histocompatibility complex, class I, B 0.0303147
ANKRD11 ankyrin repeat domain 11 0.0302426
GOLGA4 golgin A4 0.0301916
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.029856
RPL9 ribosomal protein L9 0.029424
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0291484
RPS6 ribosomal protein S6 0.0290277
RPL7A ribosomal protein L7a 0.028806
NAP1L1 nucleosome assembly protein 1-like 1 0.0287005
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0286921
CXCL8 chemokine (C-X-C motif) ligand 8 0.0285985
NIPBL Nipped-B homolog (Drosophila) 0.0285704
PDIA3 protein disulfide isomerase family A, member 3 0.0285261
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0281429
ZFP36L1 ZFP36 ring finger protein-like 1 0.0281253
BIRC3 baculoviral IAP repeat containing 3 0.0278507
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0270318
ANGPTL4 angiopoietin-like 4 0.0270177
RPL31 ribosomal protein L31 0.0267295
TPT1 tumor protein, translationally-controlled 1 0.0265648
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.026461
PRRC2C proline-rich coiled-coil 2C 0.0263654
TXNRD1 thioredoxin reductase 1 0.0263211
MYH9 myosin, heavy chain 9, non-muscle 0.0262096
TPI1 triosephosphate isomerase 1 0.0260886
EGR1 early growth response 1 0.0256684
RPS23 ribosomal protein S23 0.0252861
TGM2 transglutaminase 2 0.0252455
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0251908
RPS25 ribosomal protein S25 0.0250806
SRRM2 serine/arginine repetitive matrix 2 0.0249846
DGKD diacylglycerol kinase, delta 130kDa 0.0249703
ESYT2 extended synaptotagmin-like protein 2 0.0248367
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0248201
NDRG1 N-myc downstream regulated 1 0.0247218
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.024501
RPL26 ribosomal protein L26 0.0241525
DARS1 aspartyl-tRNA synthetase 1 0.0235715
PICALM phosphatidylinositol binding clathrin assembly protein 0.0235623
MYO9B myosin IXB 0.0234399
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0234027
RPL37A ribosomal protein L37a 0.0231798
RPS27A ribosomal protein S27a 0.0231077
JMJD1C jumonji domain containing 1C 0.0227151
IRAK2 interleukin-1 receptor-associated kinase 2 0.0226149
TPM4 tropomyosin 4 0.0223297
TMF1 TATA element modulatory factor 1 0.0222411
CEP290 centrosomal protein 290kDa 0.0222082
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0220567
AKAP9 A kinase (PRKA) anchor protein 9 0.0220172
RPL11 ribosomal protein L11 0.0219286
RPLP0 ribosomal protein, large, P0 0.0218709

decreased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0779999
PRKCA protein kinase C, alpha -0.0647388
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0635575
HMGA2 high mobility group AT-hook 2 -0.0612122
DST dystonin -0.05981
PRSS23 protease, serine, 23 -0.0538937
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.05338
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0526294
NAV2 neuron navigator 2 -0.0521145
INTS6 integrator complex subunit 6 -0.0517472
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0462416
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0415469
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0407537
TAS2R14 taste receptor, type 2, member 14 -0.0391027
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0383858
AHNAK AHNAK nucleoprotein -0.0370463
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0370275
ARMH4 armadillo like helical domain containing 4 -0.0358838
THSD4 thrombospondin, type I, domain containing 4 -0.0353952
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0348181
PRH1 proline-rich protein HaeIII subfamily 1 -0.0347496
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.033537
ASXL1 additional sex combs like transcriptional regulator 1 -0.0334328
ATG7 autophagy related 7 -0.0329989
RAD51B RAD51 paralog B -0.0312131
PTPRK protein tyrosine phosphatase, receptor type, K -0.0307873
FUS FUS RNA binding protein -0.0303602
ERBIN erbb2 interacting protein -0.0296706
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0295464
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0295045
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0292089
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0288726
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0280929
GNAS GNAS complex locus -0.0280707
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0274143
DPYD dihydropyrimidine dehydrogenase -0.0268402
FBXO11 F-box protein 11 -0.0264911
NDEL1 nudE neurodevelopment protein 1-like 1 -0.0264107
VCL vinculin -0.0262833
ZBTB20 zinc finger and BTB domain containing 20 -0.0260921
EXOC4 exocyst complex component 4 -0.0260538
IGF1R insulin-like growth factor 1 receptor -0.0254841
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0253476
SMAD2 SMAD family member 2 -0.0253433
NINL ninein-like -0.0250894
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0248871
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0247198
KIAA1671 KIAA1671 -0.0245789
FLNA filamin A, alpha -0.0243481
ZEB1 zinc finger E-box binding homeobox 1 -0.0242229
ACER3 alkaline ceramidase 3 -0.0241405
FOXO3 forkhead box O3 -0.0240645
TBCA tubulin folding cofactor A -0.0240452
NT5E 5'-nucleotidase, ecto (CD73) -0.0238497
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.023764
HMGB1 high mobility group box 1 -0.0236657
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.023514
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0234722
MACF1 microtubule-actin crosslinking factor 1 -0.0233821
AK1 adenylate kinase 1 -0.0232559
DMXL1 Dmx-like 1 -0.0230617
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0229165
GPR75-ASB3 GPR75-ASB3 readthrough -0.0228504
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.022669
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0225394
TCF12 transcription factor 12 -0.0225123
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0223022
NUP153 nucleoporin 153kDa -0.0220884
ANKLE2 ankyrin repeat and LEM domain containing 2 -0.0218548
TNRC18 trinucleotide repeat containing 18 -0.0217811
TRIP12 thyroid hormone receptor interactor 12 -0.0217171
BBX bobby sox homolog (Drosophila) -0.0214298
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0213253
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0212156
FBXL7 F-box and leucine-rich repeat protein 7 -0.0210198
COPB1 coatomer protein complex, subunit beta 1 -0.0209624
RASAL2 RAS protein activator like 2 -0.0209521
RBM39 RNA binding motif protein 39 -0.0203421
RAI14 retinoic acid induced 14 -0.0202976
CHIC2 cysteine-rich hydrophobic domain 2 -0.0202969
RIGI RNA sensor RIG-I -0.0201235
SCLT1 sodium channel and clathrin linker 1 -0.0199655
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0199101
ZNF451 zinc finger protein 451 -0.0198981
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0198977
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0196441
EPN2 epsin 2 -0.0195483
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0195262
PCNX2 pecanex 2 -0.0194619
BICD1 bicaudal D homolog 1 (Drosophila) -0.0194344
SDC4 syndecan 4 -0.0194088
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0193206
PARD3 par-3 family cell polarity regulator -0.0191972
RSF1 remodeling and spacing factor 1 -0.0191428
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0191321
TRIO trio Rho guanine nucleotide exchange factor -0.019109
PRR16 proline rich 16 -0.0189202
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.018899
CCND1 cyclin D1 -0.0188026
RUNX1 runt-related transcription factor 1 -0.0187233