CP21R7_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the CP21R7_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.045447
TXNIP thioredoxin interacting protein 0.0436813
FTH1 ferritin, heavy polypeptide 1 0.0405236
FAM13A family with sequence similarity 13, member A 0.0387793
PKM pyruvate kinase, muscle 0.0368661
FNDC3B fibronectin type III domain containing 3B 0.0368489
SMAD3 SMAD family member 3 0.0347923
VEGFA vascular endothelial growth factor A 0.0321016
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0319869
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0309757
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0282977
ESYT2 extended synaptotagmin-like protein 2 0.0270333
RICTOR RPTOR independent companion of MTOR, complex 2 0.0269097
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0265802
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0260899
GRB10 growth factor receptor-bound protein 10 0.0260508
RNF145 ring finger protein 145 0.0259593
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0258118
SSBP2 single-stranded DNA binding protein 2 0.0257643
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0253
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0250718
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0250501
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0245129
CD44 CD44 molecule (Indian blood group) 0.0244191
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0231587
COPA coatomer protein complex, subunit alpha 0.0228676
BIRC3 baculoviral IAP repeat containing 3 0.0227896
FOSL1 FOS-like antigen 1 0.0227496
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0213718
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0212749
CD109 CD109 molecule 0.0212702
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0207801
EZR ezrin 0.0204061
SEC23A Sec23 homolog A (S. cerevisiae) 0.0203832
UBA6 ubiquitin-like modifier activating enzyme 6 0.020039
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0198914
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0183734
YBX3 Y box binding protein 3 0.0183557
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0183249
MBNL1 muscleblind-like splicing regulator 1 0.0182137
ZSWIM6 zinc finger, SWIM-type containing 6 0.0179708
LOC112694756 uncharaterized LOC112694756 0.0178074
FAT1 FAT atypical cadherin 1 0.0178039
INSIG2 insulin induced gene 2 0.0178038
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0177475
TPM3 tropomyosin 3 0.0176215
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0174199
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0172906
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0171135
PELI1 pellino E3 ubiquitin protein ligase 1 0.0168867
NDRG1 N-myc downstream regulated 1 0.0168355
KDM2A lysine (K)-specific demethylase 2A 0.0166547
KMT2E lysine (K)-specific methyltransferase 2E 0.016632
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0165225
RPL3 ribosomal protein L3 0.0164446
MAP1B microtubule-associated protein 1B 0.0158274
ITGAV integrin, alpha V 0.0155503
PTBP3 polypyrimidine tract binding protein 3 0.0152354
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0150713
SVIL supervillin 0.0149456
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0147806
SIK3 SIK family kinase 3 0.0147715
SGMS2 sphingomyelin synthase 2 0.014677
DOCK5 dedicator of cytokinesis 5 0.0146703
NUP58 nucleoporin 58 0.014513
TGM2 transglutaminase 2 0.0142815
HELZ helicase with zinc finger 0.0142748
CRY1 cryptochrome circadian clock 1 0.0142515
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.014091
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0140667
AFF1 AF4/FMR2 family, member 1 0.0139454
PTK2 protein tyrosine kinase 2 0.0138246
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0137016
ARHGAP12 Rho GTPase activating protein 12 0.0136674
RAB8B RAB8B, member RAS oncogene family 0.0136285
ATP13A3 ATPase type 13A3 0.0135988
SOX9 SRY (sex determining region Y)-box 9 0.0135612
ATP9A ATPase, class II, type 9A 0.0135041
YAP1 Yes-associated protein 1 0.0134945
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0132194
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0131369
RNF149 ring finger protein 149 0.0131074
EMP1 epithelial membrane protein 1 0.0130908
MYH9 myosin, heavy chain 9, non-muscle 0.0130551
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0129678
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0129562
IL6R interleukin 6 receptor 0.0129329
AXL AXL receptor tyrosine kinase 0.0128927
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0126883
RB1CC1 RB1-inducible coiled-coil 1 0.0125594
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0124866
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0124175
RASEF RAS and EF-hand domain containing 0.012209
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0120292
AKAP13 A kinase (PRKA) anchor protein 13 0.0118509
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0118271
RPS18 ribosomal protein S18 0.0117574
AFDN afadin, adherens junction formation factor 0.0117365
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0116418
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0116332

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.249465
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.224571
NRG1 neuregulin 1 -0.214671
PTMA prothymosin, alpha -0.170894
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.165004
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.135142
CANX calnexin -0.130485
FN1 fibronectin 1 -0.126919
SQSTM1 sequestosome 1 -0.122588
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120962
HMGA2 high mobility group AT-hook 2 -0.0837291
TMSB10 thymosin beta 10 -0.0806649
VCL vinculin -0.0780413
ITGA1 integrin, alpha 1 -0.074319
HLA-B major histocompatibility complex, class I, B -0.0736882
FTL ferritin, light polypeptide -0.0716435
S100A6 S100 calcium binding protein A6 -0.0671247
TMSB4X thymosin beta 4, X-linked -0.0631007
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0516103
VIM vimentin -0.0507183
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0502485
SYT1 synaptotagmin I -0.0496109
TPT1 tumor protein, translationally-controlled 1 -0.04898
IFI27 interferon, alpha-inducible protein 27 -0.0482503
IER3 immediate early response 3 -0.0466005
AEBP2 AE binding protein 2 -0.0454701
HDLBP high density lipoprotein binding protein -0.0418712
H1-0 H1.0 linker histone -0.0416306
TAS2R14 taste receptor, type 2, member 14 -0.0414734
PALLD palladin, cytoskeletal associated protein -0.0413112
SLC38A2 solute carrier family 38, member 2 -0.0393195
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0391863
GNAS GNAS complex locus -0.0390389
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0386142
RAI14 retinoic acid induced 14 -0.0375785
AHNAK AHNAK nucleoprotein -0.0374979
ACTG1 actin gamma 1 -0.036732
EXT1 exostosin glycosyltransferase 1 -0.0353613
CALR calreticulin -0.034766
RPS24 ribosomal protein S24 -0.0344103
TM4SF1 transmembrane 4 L six family member 1 -0.0343198
SOX4 SRY (sex determining region Y)-box 4 -0.0342861
SFTPA2 surfactant protein A2 -0.0342414
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0337756
BZW1 basic leucine zipper and W2 domains 1 -0.0337631
LRRC23 leucine rich repeat containing 23 -0.0333422
INTS6 integrator complex subunit 6 -0.033242
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0329505
LIMCH1 LIM and calponin homology domains 1 -0.0315678
RPS6 ribosomal protein S6 -0.0311748
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.031157
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0305811
RPL26 ribosomal protein L26 -0.0305294
STC2 stanniocalcin 2 -0.0304798
AHR aryl hydrocarbon receptor -0.0303678
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0303139
TMEM263 transmembrane protein 263 -0.030142
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0301392
OSMR oncostatin M receptor -0.0300873
RPL38 ribosomal protein L38 -0.0300736
RPS8 ribosomal protein S8 -0.0298761
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0298337
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0296518
RPL35A ribosomal protein L35a -0.0296449
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0293628
RPLP1 ribosomal protein, large, P1 -0.0291628
RACK1 receptor for activated C kinase 1 -0.029094
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0288578
PDIA4 protein disulfide isomerase family A, member 4 -0.0286694
RPL37A ribosomal protein L37a -0.0282786
TMEM165 transmembrane protein 165 -0.0278393
BICD1 bicaudal D homolog 1 (Drosophila) -0.0274395
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.027297
DNAH5 dynein, axonemal, heavy chain 5 -0.0266849
RPL31 ribosomal protein L31 -0.0256953
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0256723
S100A9 S100 calcium binding protein A9 -0.0253971
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0253554
MAML2 mastermind-like 2 (Drosophila) -0.0253322
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.025089
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0249298
RPS21 ribosomal protein S21 -0.0242629
ZNF217 zinc finger protein 217 -0.0242089
RPS11 ribosomal protein S11 -0.0240903
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0239601
CDK13 cyclin-dependent kinase 13 -0.0238965
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0238717
XAF1 XIAP associated factor 1 -0.0238454
PHF3 PHD finger protein 3 -0.0237077
RPS29 ribosomal protein S29 -0.0236617
RANBP17 RAN binding protein 17 -0.0236263
RPS19 ribosomal protein S19 -0.0236101
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0233365
CALU calumenin -0.0233254
SPDYA speedy/RINGO cell cycle regulator family member A -0.0232694
IFI16 interferon, gamma-inducible protein 16 -0.0232691
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0231182
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0229882
RPS5 ribosomal protein S5 -0.022979
TFPI2 tissue factor pathway inhibitor 2 -0.0228613