CPD Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description carboxypeptidase D|The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1362)
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Genes

346 genes differentially expressed following the CPD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GPR162 G protein-coupled receptor 162 3.6794
RSPO3 R-spondin 3 3.6794
MUSK muscle, skeletal, receptor tyrosine kinase 3.6794
FAM86B2 family with sequence similarity 86, member B2 3.6794
GYPB glycophorin B (MNS blood group) 3.6794
GPR26 G protein-coupled receptor 26 3.6794
LYNX1 Ly6/neurotoxin 1 3.6794
TRIM77 tripartite motif containing 77 3.6794
ANKRD34A ankyrin repeat domain 34A 3.6794
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 3.6794
GCKR glucokinase (hexokinase 4) regulator 3.6794
MSC musculin 3.6794
ARHGAP36 Rho GTPase activating protein 36 3.6794
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 3.6794
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.6794
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 3.6794
NANOS2 nanos homolog 2 (Drosophila) 3.6794
FOXA1 forkhead box A1 3.6794
TNNT3 troponin T type 3 (skeletal, fast) 3.6794
CRISP1 cysteine-rich secretory protein 1 3.6794
SH2D7 SH2 domain containing 7 3.6794
SH2D6 SH2 domain containing 6 3.6794
NME5 NME/NM23 family member 5 3.6794
TMEM191B transmembrane protein 191B 3.6794
THRSP thyroid hormone responsive 3.6794
ADAMTSL5 ADAMTS-like 5 3.6794
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.6794
HES2 hes family bHLH transcription factor 2 3.6794
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.6794
HRG histidine-rich glycoprotein 3.6794
SPDEF SAM pointed domain containing ETS transcription factor 3.6794
RHOJ ras homolog family member J 3.6794
ABRA actin binding Rho activating protein 3.6794
PITX3 paired-like homeodomain 3 3.6794
ICAM2 intercellular adhesion molecule 2 3.6794
LOXL4 lysyl oxidase-like 4 3.6794
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.6794
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.6794
ETV7 ets variant 7 3.6794
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 3.6794
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 3.6794
TTLL2 tubulin tyrosine ligase-like family member 2 3.6794
KIF2B kinesin family member 2B 3.6794
SPDYE11 speedy/RINGO cell cycle regulator family member E11 3.6794
PTK6 protein tyrosine kinase 6 3.6794
BMP3 bone morphogenetic protein 3 3.6794
LGALS4 lectin, galactoside-binding, soluble, 4 3.6794
DSG3 desmoglein 3 3.6794
SP5 Sp5 transcription factor 3.6794
NLRP8 NLR family, pyrin domain containing 8 3.6794
TREM2 triggering receptor expressed on myeloid cells 2 3.6794
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.6794
CCER1 coiled-coil glutamate-rich protein 1 3.6794
DUSP9 dual specificity phosphatase 9 3.6794
ELOVL3 ELOVL fatty acid elongase 3 3.6794
C20ORF202 chromosome 20 open reading frame 202 3.6794
TRIM31 tripartite motif containing 31 3.6794
TSPAN8 tetraspanin 8 3.6794
LY6H lymphocyte antigen 6 complex, locus H 3.6794
WNT9B wingless-type MMTV integration site family, member 9B 3.6794
GPR85 G protein-coupled receptor 85 3.6794
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.6794
H1-6 H1.6 linker histone, cluster member 3.6794
MYOCOS myocilin opposite strand 3.6794
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.6794
SPMAP1 sperm microtubule associated protein 1 3.6794
SPMAP2L sperm microtubule associated protein 2 like 3.6794
CIROZ ciliated left-right organizer protein containing ZP-N domains 3.6794
PRRT1B proline rich transmembrane protein 1B 3.6794
SERTM2 serine rich and transmembrane domain containing 2 3.6794
CIBAR2 CBY1 interacting BAR domain containing 2 3.6794
ERFE erythroferrone 3.6794
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.6794
ANKRD40CL ANKRD40 C-terminal like 3.6794
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 3.6794
ARMS2 age-related maculopathy susceptibility 2 3.6794
KLRF2 killer cell lectin-like receptor subfamily F, member 2 3.6794
PCDHA2 protocadherin alpha 2 3.6794
ACTL10 actin-like 10 3.6794
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.6794
GJA3 gap junction protein, alpha 3, 46kDa 3.6794
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.6794
TMPRSS11A transmembrane protease, serine 11A 3.6794
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 3.6794
COL20A1 collagen, type XX, alpha 1 3.6794
CD274 CD274 molecule 3.6794
NOTO notochord homeobox 3.6794
LOC124906892 uncharacterized LOC124906892 3.6794
ARL5C ADP-ribosylation factor-like 5C 3.6794
C1ORF87 chromosome 1 open reading frame 87 3.6794
SH3TC2 SH3 domain and tetratricopeptide repeats 2 3.6794
GHRHR growth hormone releasing hormone receptor 3.6794
TLR6 toll-like receptor 6 3.6794
DMBX1 diencephalon/mesencephalon homeobox 1 3.6794
GOLGA7B golgin A7 family, member B 3.6794
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.6794
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.6794
CALCA calcitonin-related polypeptide alpha 3.6794
VSX2 visual system homeobox 2 3.6794
CLDN5 claudin 5 3.6794
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.6794
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.6794
AQP7 aquaporin 7 3.6794
TADA2B transcriptional adaptor 2B 3.6794
TMPPE transmembrane protein with metallophosphoesterase domain 3.6794
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 3.6794
GLOD5 glyoxalase domain containing 5 3.6794
TCAP titin-cap 3.6794
WDR44 WD repeat domain 44 3.6794
INHA inhibin, alpha 3.6794
WFDC6 WAP four-disulfide core domain 6 3.6794
THTPA thiamine triphosphatase 3.6794
GRK1 G protein-coupled receptor kinase 1 3.6794
FATE1 fetal and adult testis expressed 1 3.6794
PLA2G2C phospholipase A2, group IIC 3.6794
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 3.6794
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 3.6794
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.6794
CDH22 cadherin 22, type 2 3.6794
SLA2 Src-like-adaptor 2 3.6794
GAGE10 G antigen 10 3.6794
SH2D1B SH2 domain containing 1B 3.6794
CERS3 ceramide synthase 3 3.6794
WFDC8 WAP four-disulfide core domain 8 3.6794
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 3.6794
IL19 interleukin 19 3.6794
SYNGR4 synaptogyrin 4 3.6794
CER1 cerberus 1, DAN family BMP antagonist 3.6794
EGR2 early growth response 2 3.6794
KLK6 kallikrein-related peptidase 6 3.6794
ASTL astacin-like metallo-endopeptidase (M12 family) 3.6794
IL9R interleukin 9 receptor 3.6794
ITGB7 integrin, beta 7 3.6794
EPHA3 EPH receptor A3 3.6794
MUC17 mucin 17, cell surface associated 3.6794
IP6K3 inositol hexakisphosphate kinase 3 3.6794
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.6794
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.6794
TPSB2 tryptase beta 2 (gene/pseudogene) 3.6794
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 3.6794
BCL2L15 BCL2-like 15 3.6794
AKNAD1 AKNA domain containing 1 3.6794
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.6794
INSM1 insulinoma-associated 1 3.6794
MRAP melanocortin 2 receptor accessory protein 3.6794
PEBP4 phosphatidylethanolamine-binding protein 4 3.6794
ARL13A ADP-ribosylation factor-like 13A 3.6794
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.6794
REG1A regenerating islet-derived 1 alpha 3.6794
GJC2 gap junction protein, gamma 2, 47kDa 3.6794
TMPRSS15 transmembrane protease, serine 15 3.6794
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.6794
IFNK interferon, kappa 3.6794
CD8B CD8b molecule 3.6794
ZBED6 zinc finger, BED-type containing 6 3.6794
ZNF835 zinc finger protein 835 3.6794
SLCO1C1 solute carrier organic anion transporter family, member 1C1 3.6794
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 3.6794
SHISA3 shisa family member 3 3.6794
ITGAD integrin, alpha D 3.6794
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 3.6794
ART1 ADP-ribosyltransferase 1 3.6794
OR10G3 olfactory receptor, family 10, subfamily G, member 3 3.6794
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 3.6794
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.6794
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.6794
TRPM1 transient receptor potential cation channel, subfamily M, member 1 3.6794
AQP1 aquaporin 1 (Colton blood group) 3.6794
ETV3L ets variant 3-like 3.6794
TBC1D26 TBC1 domain family, member 26 3.6794
FITM1 fat storage-inducing transmembrane protein 1 3.6794
POTEJ POTE ankyrin domain family, member J 3.6794
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.6794
IL12B interleukin 12B 3.6794
CARD9 caspase recruitment domain family, member 9 3.6794
DKK1 dickkopf WNT signaling pathway inhibitor 1 3.6794
ANGPTL6 angiopoietin-like 6 3.6794
ECM1 extracellular matrix protein 1 3.6794
PATE1 prostate and testis expressed 1 3.6794
CLCA4 chloride channel accessory 4 3.6794
STARD5 StAR-related lipid transfer (START) domain containing 5 3.63255
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.53052
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 3.53052
FLNC filamin C, gamma 3.53052
ZFP3 ZFP3 zinc finger protein 3.53052
NBPF8 neuroblastoma breakpoint family, member 8 3.43342
RBM4 RNA binding motif protein 4 3.21717
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 3.12191
C1QL1 complement component 1, q subcomponent-like 1 3.03387
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 3.03387
C1ORF167 chromosome 1 open reading frame 167 2.98245
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 2.98245
HDGF hepatoma-derived growth factor 2.8741
TPO thyroid peroxidase 2.80372
GTF2B general transcription factor IIB 2.71134
GINS2 GINS complex subunit 2 (Psf2 homolog) 2.71105
ZMYM5 zinc finger, MYM-type 5 2.70058
TMEM167A transmembrane protein 167A 2.63528
CRYL1 crystallin, lambda 1 2.61488
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 2.61488
TWIST1 twist family bHLH transcription factor 1 2.51346
ASCL5 achaete-scute family bHLH transcription factor 5 2.51346
CTXND1 cortexin domain containing 1 2.51346
EPN3 epsin 3 2.51346
PCDH20 protocadherin 20 2.51346
IRAG1 inositol 1,4,5-triphosphate receptor associated 1 2.51202
MASTL microtubule associated serine/threonine kinase-like 2.49843
TMC1 transmembrane channel-like 1 2.4955
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 2.47142
SPACA9 sperm acrosome associated 9 2.47142
HPX hemopexin 2.47142
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 2.47142
CSPG4 chondroitin sulfate proteoglycan 4 2.47142
C9ORF153 chromosome 9 open reading frame 153 2.47142
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.45228
CASKIN1 CASK interacting protein 1 2.42308
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 2.41058
ADRA1B adrenoceptor alpha 1B 2.41058
TNRC6C trinucleotide repeat containing 6C 2.39517
ZNF443 zinc finger protein 443 2.37909
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 2.34339
RAMP1 receptor (G protein-coupled) activity modifying protein 1 2.33219
A2ML1 alpha-2-macroglobulin-like 1 2.31794
GLDN gliomedin 2.31015
GJA9 gap junction protein, alpha 9, 59kDa 2.31015
PODNL1 podocan-like 1 2.31015
TSN translin 2.28664
MYCBPAP MYCBP associated protein 2.26342
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 2.21843
TMSB15A thymosin beta 15a 2.21413
HYPK huntingtin interacting protein K 2.21295
LRRTM3 leucine rich repeat transmembrane neuronal 3 2.20455
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2.19503
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 2.18416
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 2.18347
NPHP1 nephronophthisis 1 (juvenile) 2.17251
ARFRP1 ADP-ribosylation factor related protein 1 2.16353
ZNG1B Zn regulated GTPase metalloprotein activator 1B 2.138
ANKRD13D ankyrin repeat domain 13 family, member D 2.1279
GJB7 gap junction protein, beta 7, 25kDa 2.1236
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 2.12346
SRA1 steroid receptor RNA activator 1 2.11237
PTPRM protein tyrosine phosphatase, receptor type, M 2.11171
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.04469
TYW2 tRNA wybutosine-synthesizing protein 2 2.04469
ZW10 zw10 kinetochore protein 2.04227
ATP10D ATPase, class V, type 10D 2.03815
CARM1 coactivator-associated arginine methyltransferase 1 2.03476
GOLT1B golgi transport 1B 2.03409
BMERB1 bMERB domain containing 1 2.0225
PABPN1 poly(A) binding protein, nuclear 1 2.01393

decreased expression

Symbol Name Standardized Value
LOC124902436 talanin -3.6794
POTEI POTE ankyrin domain family, member I -3.6794
CERCAM cerebral endothelial cell adhesion molecule -3.6794
ASMT acetylserotonin O-methyltransferase -3.6794
ETV2 ets variant 2 -3.6794
CLCN2 chloride channel, voltage-sensitive 2 -3.6794
TAS2R19 taste receptor, type 2, member 19 -3.6794
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -3.6794
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 -3.6794
RGPD1 RANBP2-like and GRIP domain containing 1 -3.6794
LRRC10B leucine rich repeat containing 10B -3.6794
C2ORF80 chromosome 2 open reading frame 80 -3.6794
NAGS N-acetylglutamate synthase -3.6794
LBP lipopolysaccharide binding protein -3.6794
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 -3.6794
GFRA3 GDNF family receptor alpha 3 -3.6794
TM6SF1 transmembrane 6 superfamily member 1 -3.6794
KLB klotho beta -3.6794
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 -3.6794
LIF leukemia inhibitory factor -3.6794
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -3.6794
ADAM8 ADAM metallopeptidase domain 8 -3.6794
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -3.6794
DPH1 diphthamide biosynthesis 1 -3.6794
TDRD10 tudor domain containing 10 -3.6794
NR1D1 nuclear receptor subfamily 1, group D, member 1 -3.6794
DIABLO diablo, IAP-binding mitochondrial protein -3.33416
ATP5MJ ATP synthase membrane subunit j -3.21306
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 -3.15517
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 -3.11006
CPD carboxypeptidase D -3.09991
RPL11 ribosomal protein L11 -3.08607
NKIRAS1 NFKB inhibitor interacting Ras-like 1 -3.07526
ALKAL2 ALK and LTK ligand 2 -3.06115
SAMD14 sterile alpha motif domain containing 14 -3.04358
SCAND3 SCAN domain containing 3 -3.04159
PC pyruvate carboxylase -2.99645
METTL18 methyltransferase like 18 -2.95075
RPL12 ribosomal protein L12 -2.92571
PAQR6 progestin and adipoQ receptor family member VI -2.9085
ZNF274 zinc finger protein 274 -2.90239
MYL12B myosin, light chain 12B, regulatory -2.78228
COL16A1 collagen, type XVI, alpha 1 -2.71134
MEI1 meiosis inhibitor 1 -2.71134
CD79B CD79b molecule, immunoglobulin-associated beta -2.71134
PLSCR3 phospholipid scramblase 3 -2.70322
SGCZ sarcoglycan, zeta -2.70058
HELB helicase (DNA) B -2.67998
SFXN5 sideroflexin 5 -2.64618
LMAN2L lectin, mannose-binding 2-like -2.63621
OAZ2 ornithine decarboxylase antizyme 2 -2.59834
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -2.58578
DGKG diacylglycerol kinase, gamma 90kDa -2.57738
TCL1B T-cell leukemia/lymphoma 1B -2.57738
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.51346
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.51202
GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 -2.51023
DXO decapping exoribonuclease -2.48509
FRZB frizzled-related protein -2.48509
NUDT4B nudix hydrolase 4B -2.46007
PABPC4L poly(A) binding protein, cytoplasmic 4-like -2.46007
MELTF melanotransferrin -2.43178
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 -2.43178
ATAT1 alpha tubulin acetyltransferase 1 -2.43178
REP15 RAB15 effector protein -2.42308
ABHD8 abhydrolase domain containing 8 -2.42308
ZNF540 zinc finger protein 540 -2.42308
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -2.39517
TMEM97 transmembrane protein 97 -2.37728
MED1 mediator complex subunit 1 -2.32478
LTB4R leukotriene B4 receptor -2.31345
MEIOB meiosis specific with OB domains -2.31345
SAXO4 stabilizer of axonemal microtubules 4 -2.31248
SQLE squalene epoxidase -2.29231
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -2.28664
PDZD2 PDZ domain containing 2 -2.28082
BRD7 bromodomain containing 7 -2.26957
BMPR1A bone morphogenetic protein receptor, type IA -2.25442
LDAH lipid droplet associated hydrolase -2.25361
CRYBG3 beta-gamma crystallin domain containing 3 -2.25116
IQSEC3 IQ motif and Sec7 domain 3 -2.23754
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -2.21522
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) -2.20149
AMACR alpha-methylacyl-CoA racemase -2.20119
SMC1A structural maintenance of chromosomes 1A -2.1644
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.15802
TSLIG3C tRNA splicing ligase complex subunit 3C -2.13922
ADAT2 adenosine deaminase, tRNA-specific 2 -2.138
ETNK2 ethanolamine kinase 2 -2.1236
NARS1 asparaginyl-tRNA synthetase 1 -2.11316
DAAM1 dishevelled associated activator of morphogenesis 1 -2.11139
TMEM248 transmembrane protein 248 -2.10557
SERP1 stress-associated endoplasmic reticulum protein 1 -2.10235
RAB14 RAB14, member RAS oncogene family -2.0841
AIG1 androgen-induced 1 -2.06983