CPI-203 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/71291068
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Genes

198 proteins with high or low expression in CPI-203 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.86
MT2A metallothionein 2A 2.51
VGF VGF nerve growth factor inducible 2.0
MAP2 microtubule-associated protein 2 1.76
EPPK1 epiplakin 1 1.76
IRX4 iroquois homeobox 4 1.72
FTL ferritin, light polypeptide 1.62
PNPLA2 patatin-like phospholipase domain containing 2 1.59
SORBS1 sorbin and SH3 domain containing 1 1.54
CCND3 cyclin D3 1.52
TPPP tubulin polymerization promoting protein 1.5
MIDN midnolin 1.48
CLIC3 chloride intracellular channel 3 1.42
DCXR dicarbonyl/L-xylulose reductase 1.41
PEG10 paternally expressed 10 1.41
MT1X metallothionein 1X 1.39
GCH1 GTP cyclohydrolase 1 1.37
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.32
DGKQ diacylglycerol kinase, theta 110kDa 1.3
TST thiosulfate sulfurtransferase (rhodanese) 1.3
ZNF503 zinc finger protein 503 1.29
MFGE8 milk fat globule-EGF factor 8 protein 1.29
CAPN5 calpain 5 1.28
EFNB2 ephrin-B2 1.27
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.27
FBXO33 F-box protein 33 1.26
H1-0 H1.0 linker histone 1.25
ARG2 arginase 2 1.23
JUN jun proto-oncogene 1.2
MT1E metallothionein 1E 1.18
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 1.16
HELZ2 helicase with zinc finger 2, transcriptional coactivator 1.16
TUFT1 tuftelin 1 1.16
ZER1 zyg-11 related, cell cycle regulator 1.14
DAAM1 dishevelled associated activator of morphogenesis 1 1.11
FBXL6 F-box and leucine-rich repeat protein 6 1.1
ENC1 ectodermal-neural cortex 1 (with BTB domain) 1.09
ADI1 acireductone dioxygenase 1 1.08
MTRES1 mitochondrial transcription rescue factor 1 1.07
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 1.07
L1CAM L1 cell adhesion molecule 1.06
HEXIM1 hexamethylene bis-acetamide inducible 1 1.05
KCTD21 potassium channel tetramerization domain containing 21 1.05
CCN2 cellular communication network factor 2 1.04
MT1F metallothionein 1F 1.04
ABAT 4-aminobutyrate aminotransferase 1.03
NEU1 sialidase 1 (lysosomal sialidase) 1.01
THEMIS2 thymocyte selection associated family member 2 1.0
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 0.99
PLD3 phospholipase D family, member 3 0.99
MCRIP1 MAPK regulated corepressor interacting protein 1 0.98
CLSTN3 calsyntenin 3 0.98
HMCN1 hemicentin 1 0.98
TPRN taperin 0.97
ABLIM2 actin binding LIM protein family, member 2 0.97
CCNDBP1 cyclin D-type binding-protein 1 0.97
H1FX H1 histone family, member X 0.96
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.96
FAM234A family with sequence similarity 234 member A 0.96
OPTN optineurin 0.95
MARCKSL1 MARCKS-like 1 0.95
ZFYVE1 zinc finger, FYVE domain containing 1 0.95
CLU clusterin 0.94
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.94
DGAT1 diacylglycerol O-acyltransferase 1 0.93
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.93
TRIM36 tripartite motif containing 36 0.93
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.93
STXBP1 syntaxin binding protein 1 0.92
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) 0.91
PLD1 phospholipase D1, phosphatidylcholine-specific 0.91
LRRC58 leucine rich repeat containing 58 0.91
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.9
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.9
CEMIP2 cell migration inducing hyaluronidase 2 0.89
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.89
DNAH12 dynein, axonemal, heavy chain 12 0.89
SLFN5 schlafen family member 5 0.89
BAIAP2 BAI1-associated protein 2 0.89
IRS2 insulin receptor substrate 2 0.88
EVI5L ecotropic viral integration site 5-like 0.88
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.88
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.87
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.87
SLC26A6 solute carrier family 26 (anion exchanger), member 6 0.86
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 0.86
ZNF276 zinc finger protein 276 0.85
UNC5B unc-5 homolog B (C. elegans) 0.85
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.85
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.85
GKAP1 G kinase anchoring protein 1 0.84
GLCE glucuronic acid epimerase 0.84
BAHD1 bromo adjacent homology domain containing 1 0.84
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.84
FTH1 ferritin, heavy polypeptide 1 0.84
PRAF2 PRA1 domain family, member 2 0.83
ALAD aminolevulinate dehydratase 0.83
ACVR2A activin A receptor, type IIA 0.82

low expression

Symbol Name Standardized Value
SYTL3 synaptotagmin-like 3 -2.46
EPN3 epsin 3 -2.21
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -2.17
PDE4B phosphodiesterase 4B, cAMP-specific -2.06
EHF ets homologous factor -1.91
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -1.91
EREG epiregulin -1.86
KLK6 kallikrein-related peptidase 6 -1.83
ADGRF1 adhesion G protein-coupled receptor F1 -1.8
IFIH1 interferon induced with helicase C domain 1 -1.78
DCLRE1A DNA cross-link repair 1A -1.76
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria -1.73
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -1.72
CARD8 caspase recruitment domain family, member 8 -1.68
NRP1 neuropilin 1 -1.66
TYRO3 TYRO3 protein tyrosine kinase -1.65
TNS4 tensin 4 -1.62
CASP4 caspase 4, apoptosis-related cysteine peptidase -1.59
ANKRD22 ankyrin repeat domain 22 -1.53
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -1.52
ERRFI1 ERBB receptor feedback inhibitor 1 -1.5
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -1.49
IFRD1 interferon-related developmental regulator 1 -1.48
DDR1 discoidin domain receptor tyrosine kinase 1 -1.48
MYH15 myosin, heavy chain 15 -1.47
AREG amphiregulin -1.47
FGFBP1 fibroblast growth factor binding protein 1 -1.47
GRHL2 grainyhead-like 2 (Drosophila) -1.45
TACSTD2 tumor-associated calcium signal transducer 2 -1.43
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -1.42
FOXM1 forkhead box M1 -1.39
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -1.38
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial -1.37
SYNE4 spectrin repeat containing, nuclear envelope family member 4 -1.36
STC2 stanniocalcin 2 -1.36
CEP72 centrosomal protein 72kDa -1.35
ADGRG1 adhesion G protein-coupled receptor G1 -1.35
SMAD1 SMAD family member 1 -1.35
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like -1.33
IL27RA interleukin 27 receptor, alpha -1.32
WDR76 WD repeat domain 76 -1.31
SH3RF2 SH3 domain containing ring finger 2 -1.31
TRAF3IP2 TRAF3 interacting protein 2 -1.3
MACC1 metastasis associated in colon cancer 1 -1.3
TRIB1 tribbles pseudokinase 1 -1.29
PHF19 PHD finger protein 19 -1.26
PCSK9 proprotein convertase subtilisin/kexin type 9 -1.26
SCNN1A sodium channel, non voltage gated 1 alpha subunit -1.26
TPGS2 tubulin polyglutamylase complex subunit 2 -1.26
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -1.25
SCARA3 scavenger receptor class A, member 3 -1.25
NAV3 neuron navigator 3 -1.24
ARHGAP22 Rho GTPase activating protein 22 -1.24
PLAU plasminogen activator, urokinase -1.22
L3MBTL3 l(3)mbt-like 3 (Drosophila) -1.21
HOXB8 homeobox B8 -1.21
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -1.21
DUSP9 dual specificity phosphatase 9 -1.19
ZNF114 zinc finger protein 114 -1.19
AKAP12 A kinase (PRKA) anchor protein 12 -1.19
ARMC4 armadillo repeat containing 4 -1.18
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -1.17
VIM vimentin -1.17
CDCA7 cell division cycle associated 7 -1.16
CUEDC2 CUE domain containing 2 -1.15
RAD51AP1 RAD51 associated protein 1 -1.14
ZBTB20 zinc finger and BTB domain containing 20 -1.14
TBC1D32 TBC1 domain family, member 32 -1.14
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B -1.13
GMNN geminin, DNA replication inhibitor -1.12
IQCG IQ motif containing G -1.12
GLT8D1 glycosyltransferase 8 domain containing 1 -1.12
UNC13D unc-13 homolog D (C. elegans) -1.11
JADE2 jade family PHD finger 2 -1.1
SGO1 shugoshin 1 -1.1
CCNA2 cyclin A2 -1.1
PLD6 phospholipase D family, member 6 -1.1
OLFM2 olfactomedin 2 -1.1
MCM10 minichromosome maintenance complex component 10 -1.09
IRS1 insulin receptor substrate 1 -1.09
MVB12B multivesicular body subunit 12B -1.09
EGR1 early growth response 1 -1.09
DIXDC1 DIX domain containing 1 -1.08
ANO1 anoctamin 1, calcium activated chloride channel -1.07
MMP14 matrix metallopeptidase 14 (membrane-inserted) -1.07
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -1.06
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -1.06
PARP8 poly (ADP-ribose) polymerase family, member 8 -1.06
PRAME preferentially expressed antigen in melanoma -1.05
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -1.05
WNT10B wingless-type MMTV integration site family, member 10B -1.04
HAS3 hyaluronan synthase 3 -1.04
CARD10 caspase recruitment domain family, member 10 -1.04
KCTD15 potassium channel tetramerization domain containing 15 -1.04
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -1.04
F3 coagulation factor III (thromboplastin, tissue factor) -1.03
AP4S1 adaptor-related protein complex 4, sigma 1 subunit -1.03
TMEM98 transmembrane protein 98 -1.03
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -1.03
GPRC5B G protein-coupled receptor, class C, group 5, member B -1.03