| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | complement component (3b/4b) receptor 1 (Knops blood group)|This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1378) |
| External Link | https://ncbi.nlm.nih.gov/gene/1378 |
| Similar Terms | |
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499 genes differentially expressed following the CR1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0149904 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0135617 |
| BMP4 | bone morphogenetic protein 4 | 0.0125833 |
| S100A8 | S100 calcium binding protein A8 | 0.0123637 |
| KRT5 | keratin 5, type II | 0.0114987 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0110857 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0107266 |
| S100A2 | S100 calcium binding protein A2 | 0.0104317 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0102283 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 0.0101324 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00997835 |
| KRT14 | keratin 14, type I | 0.00958018 |
| MAP7 | microtubule-associated protein 7 | 0.00941107 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00939814 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.00935207 |
| S100A7 | S100 calcium binding protein A7 | 0.00915881 |
| WDR7 | WD repeat domain 7 | 0.00904862 |
| LCN2 | lipocalin 2 | 0.00901229 |
| KRT17 | keratin 17, type I | 0.00900284 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | 0.00898444 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00896494 |
| TARP | TCR gamma alternate reading frame protein | 0.00878615 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00871965 |
| NVL | nuclear VCP-like | 0.00855472 |
| KRT6A | keratin 6A, type II | 0.00844701 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.00830695 |
| TRIM14 | tripartite motif containing 14 | 0.00822057 |
| COG7 | component of oligomeric golgi complex 7 | 0.0082014 |
| IFI44L | interferon-induced protein 44-like | 0.00818572 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.00806509 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.0077546 |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | 0.00765013 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | 0.00755217 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.00754867 |
| WASHC4 | WASH complex subunit 4 | 0.00744004 |
| IL7R | interleukin 7 receptor | 0.00742722 |
| CST7 | cystatin F (leukocystatin) | 0.00739571 |
| S100A9 | S100 calcium binding protein A9 | 0.00739135 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00735353 |
| ARG1 | arginase 1 | 0.00727172 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.00722611 |
| SOCS2 | suppressor of cytokine signaling 2 | 0.00719399 |
| MT1F | metallothionein 1F | 0.00714043 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00710361 |
| CRYM | crystallin, mu | 0.00705786 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.0070293 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00702032 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00698531 |
| NUAK1 | NUAK family, SNF1-like kinase, 1 | 0.00697601 |
| VSNL1 | visinin-like 1 | 0.00691238 |
| SP110 | SP110 nuclear body protein | 0.00685841 |
| ZNF91 | zinc finger protein 91 | 0.00685023 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.00684996 |
| OPTN | optineurin | 0.00682293 |
| GPX1 | glutathione peroxidase 1 | 0.006818 |
| SPRR1A | small proline-rich protein 1A | 0.0067612 |
| FOXC1 | forkhead box C1 | 0.00675663 |
| PRPF4 | pre-mRNA processing factor 4 | 0.00667642 |
| IFIT5 | interferon-induced protein with tetratricopeptide repeats 5 | 0.00667619 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.0065875 |
| SYT1 | synaptotagmin I | 0.0065806 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.00656044 |
| MX1 | MX dynamin-like GTPase 1 | 0.00646124 |
| SPRR1B | small proline-rich protein 1B | 0.00644171 |
| KRT6B | keratin 6B, type II | 0.00641347 |
| INHBA | inhibin, beta A | 0.0063875 |
| L1CAM | L1 cell adhesion molecule | 0.00634745 |
| CFB | complement factor B | 0.0062062 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | 0.00620437 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.00616956 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 0.00616264 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.00615712 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.00614353 |
| CD52 | CD52 molecule | 0.00614033 |
| HBD | hemoglobin, delta | 0.00613615 |
| IFI35 | interferon-induced protein 35 | 0.00611697 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.00606929 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | 0.00601414 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00599676 |
| QDPR | quinoid dihydropteridine reductase | 0.00596336 |
| KRT16 | keratin 16, type I | 0.00596096 |
| ATOX1 | antioxidant 1 copper chaperone | 0.00594027 |
| BTN3A3 | butyrophilin, subfamily 3, member A3 | 0.00587426 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.00585891 |
| OGDHL | oxoglutarate dehydrogenase-like | 0.00582659 |
| MMP9 | matrix metallopeptidase 9 | 0.00579167 |
| SFN | stratifin | 0.00578352 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.00577527 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.00576729 |
| DEFB1 | defensin, beta 1 | 0.00573893 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | 0.00571543 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | 0.00570537 |
| QPRT | quinolinate phosphoribosyltransferase | 0.00568813 |
| USP18 | ubiquitin specific peptidase 18 | 0.00567117 |
| CALML3 | calmodulin-like 3 | 0.00566264 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.00564147 |
| RAB29 | RAB29, member RAS oncogene family | 0.00562154 |
| RXYLT1 | ribitol xylosyltransferase 1 | 0.0056189 |
| IFI44 | interferon-induced protein 44 | 0.00561724 |
| MT2A | metallothionein 2A | 0.00561238 |
| LIMA1 | LIM domain and actin binding 1 | 0.00559934 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 0.00559154 |
| CALML5 | calmodulin-like 5 | 0.00558808 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 0.0055702 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.00554433 |
| PRSS21 | protease, serine, 21 (testisin) | 0.00549268 |
| MSLN | mesothelin | 0.00548946 |
| TSNAX | translin-associated factor X | 0.00548878 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.00547808 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.0054778 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.00545582 |
| IL1RN | interleukin 1 receptor antagonist | 0.00542813 |
| CLCA2 | chloride channel accessory 2 | 0.00542432 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 0.0054218 |
| IRF7 | interferon regulatory factor 7 | 0.00537911 |
| MT1X | metallothionein 1X | 0.00536792 |
| TYRP1 | tyrosinase-related protein 1 | 0.00536093 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 0.00535401 |
| HCP5 | HLA complex P5 (non-protein coding) | 0.00533399 |
| MT1H | metallothionein 1H | 0.00532706 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00530878 |
| DCK | deoxycytidine kinase | 0.00529817 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | 0.00528473 |
| MT1E | metallothionein 1E | 0.00528439 |
| SOSTDC1 | sclerostin domain containing 1 | 0.005278 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0052603 |
| SPRR2B | small proline-rich protein 2B | 0.00525311 |
| EFNA1 | ephrin-A1 | 0.00524836 |
| MPHOSPH8 | M-phase phosphoprotein 8 | 0.00524205 |
| MT1G | metallothionein 1G | 0.00523952 |
| AVPI1 | arginine vasopressin-induced 1 | 0.00521462 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00520654 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.00520462 |
| CDH13 | cadherin 13 | 0.0051977 |
| FGGY | FGGY carbohydrate kinase domain containing | 0.00519764 |
| IRF9 | interferon regulatory factor 9 | 0.00517256 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.00516985 |
| PTPRCAP | protein tyrosine phosphatase, receptor type, C-associated protein | 0.00516359 |
| GNMT | glycine N-methyltransferase | 0.0051414 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | 0.00514097 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 0.00513856 |
| LYRM4 | LYR motif containing 4 | 0.0051335 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | 0.00512312 |
| PKP1 | plakophilin 1 | 0.0051228 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.00509662 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | 0.0050778 |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | 0.00507285 |
| TMEM140 | transmembrane protein 140 | 0.00506597 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.00506191 |
| CCND3 | cyclin D3 | 0.0050592 |
| RTP4 | receptor (chemosensory) transporter protein 4 | 0.00505676 |
| HOXB13 | homeobox B13 | 0.0050436 |
| DUSP2 | dual specificity phosphatase 2 | 0.00503881 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.00501685 |
| MVP | major vault protein | 0.00499502 |
| CDA | cytidine deaminase | 0.0049739 |
| KRT1 | keratin 1, type II | 0.00497094 |
| CNPY3 | canopy FGF signaling regulator 3 | 0.00496811 |
| FOLR1 | folate receptor 1 (adult) | 0.00495847 |
| CREBL2 | cAMP responsive element binding protein-like 2 | 0.00495643 |
| SLC44A4 | solute carrier family 44, member 4 | 0.00495396 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 0.00494122 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.00492854 |
| DLEU1 | deleted in lymphocytic leukemia 1 (non-protein coding) | 0.00492517 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0049175 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | 0.00491066 |
| CCNA1 | cyclin A1 | 0.00490135 |
| IPP | intracisternal A particle-promoted polypeptide | 0.0048938 |
| FMO4 | flavin containing monooxygenase 4 | 0.00488458 |
| CD8A | CD8a molecule | 0.00487877 |
| ACOT13 | acyl-CoA thioesterase 13 | 0.00487195 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.00484437 |
| CYP27A1 | cytochrome P450, family 27, subfamily A, polypeptide 1 | 0.00483259 |
| GCAT | glycine C-acetyltransferase | 0.00483233 |
| PHF20 | PHD finger protein 20 | 0.00483217 |
| DNASE1L3 | deoxyribonuclease I-like 3 | 0.0048238 |
| BHMT | betaine--homocysteine S-methyltransferase | 0.00482035 |
| ZNF430 | zinc finger protein 430 | 0.00481207 |
| ADAT1 | adenosine deaminase, tRNA-specific 1 | 0.00480917 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | 0.00480873 |
| BPIFA1 | BPI fold containing family A, member 1 | 0.0048078 |
| TSPAN1 | tetraspanin 1 | 0.00480416 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.00480145 |
| COPE | coatomer protein complex, subunit epsilon | 0.0047975 |
| STYXL1 | serine/threonine/tyrosine interacting-like 1 | 0.00478663 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.00478247 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.0047746 |
| YPEL5 | yippee-like 5 (Drosophila) | 0.00474177 |
| CWH43 | cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) | 0.00473306 |
| IRF6 | interferon regulatory factor 6 | 0.00473196 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 0.00473143 |
| CLC | Charcot-Leyden crystal galectin | 0.00472999 |
| ZNHIT1 | zinc finger, HIT-type containing 1 | 0.00472768 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 0.00469377 |
| PAH | phenylalanine hydroxylase | 0.00469172 |
| MRPS11 | mitochondrial ribosomal protein S11 | 0.00467849 |
| AMH | anti-Mullerian hormone | 0.00466811 |
| FKBP11 | FK506 binding protein 11, 19 kDa | 0.00466628 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.00466419 |
| KLK7 | kallikrein-related peptidase 7 | 0.00466358 |
| FIBP | fibroblast growth factor (acidic) intracellular binding protein | 0.00466293 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.00466026 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.00465426 |
| CD177 | CD177 molecule | 0.00465259 |
| NDRG4 | NDRG family member 4 | 0.00463878 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 0.0046299 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.00461128 |
| C9ORF16 | chromosome 9 open reading frame 16 | 0.00458665 |
| LITAF | lipopolysaccharide-induced TNF factor | 0.00456687 |
| ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 | 0.0045657 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.00456539 |
| RABIF | RAB interacting factor | 0.00456453 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | 0.00455699 |
| WISP3 | WNT1 inducible signaling pathway protein 3 | 0.00455442 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.00455334 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | 0.00453507 |
| CNP | 2',3'-cyclic nucleotide 3' phosphodiesterase | 0.00453325 |
| COX7A2L | cytochrome c oxidase subunit VIIa polypeptide 2 like | 0.00453242 |
| HLA-B | major histocompatibility complex, class I, B | 0.00451928 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 0.00451881 |
| TFR2 | transferrin receptor 2 | 0.0045125 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.00449867 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.00449486 |
| SDC1 | syndecan 1 | 0.00449135 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.00448788 |
| GM2A | GM2 ganglioside activator | 0.00448417 |
| DSG1 | desmoglein 1 | 0.0044806 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00446936 |
| COPS7A | COP9 signalosome subunit 7A | 0.00444858 |
| APLP1 | amyloid beta (A4) precursor-like protein 1 | 0.00443119 |
| HLA-A | major histocompatibility complex, class I, A | 0.00442368 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | 0.00441937 |
| POLDIP2 | polymerase (DNA-directed), delta interacting protein 2 | 0.00441362 |
| HLA-C | major histocompatibility complex, class I, C | 0.00440658 |
| PHB2 | prohibitin 2 | 0.00440589 |
| MYCL | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog | 0.00440209 |
| SV2B | synaptic vesicle glycoprotein 2B | 0.00437919 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.00436567 |
| SORBS3 | sorbin and SH3 domain containing 3 | 0.004363 |
| NCDN | neurochondrin | 0.00435486 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | 0.00435257 |
| KYNU | kynureninase | 0.00434852 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | 0.0043364 |
| ANG | angiogenin, ribonuclease, RNase A family, 5 | 0.00433141 |
| GPR137B | G protein-coupled receptor 137B | 0.00432135 |
| MRPL49 | mitochondrial ribosomal protein L49 | 0.00432059 |
| GPI | glucose-6-phosphate isomerase | 0.00430864 |
| GMPR | guanosine monophosphate reductase | 0.00429352 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | 0.00427843 |
| SLC6A12 | solute carrier family 6 (neurotransmitter transporter), member 12 | 0.00427821 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AGR2 | anterior gradient 2 | -0.0141191 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0137254 |
| COL15A1 | collagen, type XV, alpha 1 | -0.0128843 |
| RRAGA | Ras-related GTP binding A | -0.0117957 |
| SNX7 | sorting nexin 7 | -0.0110839 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.0110381 |
| XIC | X chromosome inactivation center | -0.0106427 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0102782 |
| KRT19 | keratin 19, type I | -0.0101733 |
| TFF3 | trefoil factor 3 (intestinal) | -0.0100666 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.00997348 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00986508 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.00907372 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00901478 |
| BEX1 | brain expressed, X-linked 1 | -0.00884641 |
| MAGEA3 | melanoma antigen family A3 | -0.00873635 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | -0.00861876 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | -0.00861832 |
| SRPX | sushi-repeat containing protein, X-linked | -0.00860802 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00856371 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00850463 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.00845416 |
| NLGN4X | neuroligin 4, X-linked | -0.00841066 |
| THBS4 | thrombospondin 4 | -0.00840047 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.00834273 |
| CCNB1 | cyclin B1 | -0.00832667 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00829769 |
| FCGBP | Fc fragment of IgG binding protein | -0.00829733 |
| SYNM | synemin, intermediate filament protein | -0.0082533 |
| FHL1 | four and a half LIM domains 1 | -0.00792358 |
| CNN3 | calponin 3, acidic | -0.00792014 |
| EPCAM | epithelial cell adhesion molecule | -0.00790217 |
| MAOA | monoamine oxidase A | -0.00788404 |
| APOB | apolipoprotein B | -0.00779813 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.00778334 |
| STC1 | stanniocalcin 1 | -0.00777428 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.00776572 |
| SCD5 | stearoyl-CoA desaturase 5 | -0.00773109 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.00769511 |
| REG1A | regenerating islet-derived 1 alpha | -0.00763097 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.00755042 |
| DLG5 | discs, large homolog 5 (Drosophila) | -0.00744454 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.00738892 |
| CTSZ | cathepsin Z | -0.00736755 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0072973 |
| REG3A | regenerating islet-derived 3 alpha | -0.00729585 |
| HEPH | hephaestin | -0.00729452 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00724081 |
| MAGEA12 | melanoma antigen family A12 | -0.00719305 |
| NOVA1 | neuro-oncological ventral antigen 1 | -0.00715096 |
| ALOX5 | arachidonate 5-lipoxygenase | -0.00706444 |
| GALC | galactosylceramidase | -0.00702463 |
| MYBPC1 | myosin binding protein C, slow type | -0.00700749 |
| MMP1 | matrix metallopeptidase 1 | -0.00683918 |
| COL1A2 | collagen, type I, alpha 2 | -0.00681481 |
| FAM189A2 | family with sequence similarity 189, member A2 | -0.00660345 |
| NID1 | nidogen 1 | -0.00659714 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | -0.00659454 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.00659197 |
| SQLE | squalene epoxidase | -0.00658444 |
| INSR | insulin receptor | -0.00652661 |
| OGN | osteoglycin | -0.00651933 |
| CFD | complement factor D (adipsin) | -0.00647848 |
| OLFM4 | olfactomedin 4 | -0.00646251 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.00645704 |
| CBX1 | chromobox homolog 1 | -0.00644802 |
| ELOVL2 | ELOVL fatty acid elongase 2 | -0.00640258 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00639486 |
| CHRDL1 | chordin-like 1 | -0.00634897 |
| PMP22 | peripheral myelin protein 22 | -0.00631557 |
| C8ORF4 | chromosome 8 open reading frame 4 | -0.0062963 |
| EMP1 | epithelial membrane protein 1 | -0.00628791 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.00627495 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.00626544 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0062456 |
| DES | desmin | -0.00621415 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.00620466 |
| HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | -0.00618194 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.00612171 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | -0.00606052 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | -0.00604461 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.00600381 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.00599368 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.0059833 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.00597959 |
| CRY1 | cryptochrome circadian clock 1 | -0.0059794 |
| MYOT | myotilin | -0.00597883 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.00597278 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.00595396 |
| OLFML3 | olfactomedin-like 3 | -0.00593232 |
| SUN1 | Sad1 and UNC84 domain containing 1 | -0.00592422 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.00591783 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00591665 |
| TARDBP | TAR DNA binding protein | -0.00591015 |
| FSTL1 | follistatin-like 1 | -0.00590338 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.00588372 |
| NID2 | nidogen 2 (osteonidogen) | -0.0058428 |
| NELL1 | NEL-like 1 (chicken) | -0.00582477 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | -0.00578813 |
| FZD6 | frizzled class receptor 6 | -0.00578598 |
| PCDH17 | protocadherin 17 | -0.00578406 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | -0.00574158 |
| KLHL41 | kelch-like family member 41 | -0.00574138 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.00573373 |
| GYG2 | glycogenin 2 | -0.00572465 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.00571804 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | -0.00571738 |
| LAMA4 | laminin, alpha 4 | -0.00571123 |
| FZD5 | frizzled class receptor 5 | -0.00569597 |
| ANK2 | ankyrin 2, neuronal | -0.00566606 |
| EFNB2 | ephrin-B2 | -0.00564281 |
| SMC1A | structural maintenance of chromosomes 1A | -0.00561965 |
| TPBG | trophoblast glycoprotein | -0.00560527 |
| VSIG4 | V-set and immunoglobulin domain containing 4 | -0.00559502 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00559148 |
| ECT2 | epithelial cell transforming 2 | -0.0055756 |
| FADS1 | fatty acid desaturase 1 | -0.00557509 |
| HHEX | hematopoietically expressed homeobox | -0.0055499 |
| DCHS1 | dachsous cadherin-related 1 | -0.00553407 |
| PCDH9 | protocadherin 9 | -0.00552502 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00551524 |
| SOX17 | SRY (sex determining region Y)-box 17 | -0.00549617 |
| STC2 | stanniocalcin 2 | -0.00549592 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -0.00546484 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | -0.00544672 |
| FGG | fibrinogen gamma chain | -0.00543404 |
| PLIN2 | perilipin 2 | -0.00541541 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -0.00540456 |
| ALB | albumin | -0.00539472 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00538882 |
| RAI2 | retinoic acid induced 2 | -0.00534766 |
| TSPAN7 | tetraspanin 7 | -0.00533538 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.00532294 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.00532152 |
| KRT7 | keratin 7, type II | -0.00531128 |
| PNN | pinin, desmosome associated protein | -0.00530099 |
| PFDN4 | prefoldin subunit 4 | -0.00528305 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | -0.00528133 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -0.00527791 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00526795 |
| ADGRL4 | adhesion G protein-coupled receptor L4 | -0.00526137 |
| FNDC3B | fibronectin type III domain containing 3B | -0.00524898 |
| DUSP5 | dual specificity phosphatase 5 | -0.00524825 |
| ANGPT2 | angiopoietin 2 | -0.00524261 |
| PSAT1 | phosphoserine aminotransferase 1 | -0.00522892 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | -0.00522822 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | -0.00521874 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | -0.00521657 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.00519481 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00518265 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.00518035 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | -0.00516831 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.0051452 |
| VWF | von Willebrand factor | -0.00514373 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.005142 |
| TFRC | transferrin receptor | -0.00513869 |
| TNC | tenascin C | -0.00513657 |
| CDK2 | cyclin-dependent kinase 2 | -0.00512382 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.00510533 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | -0.00510178 |
| MXRA5 | matrix-remodelling associated 5 | -0.00509989 |
| CYRIA | CYFIP related Rac1 interactor A | -0.00508642 |
| SDC2 | syndecan 2 | -0.00507406 |
| SDC3 | syndecan 3 | -0.00505885 |
| CA3 | carbonic anhydrase III | -0.00505683 |
| ITM2A | integral membrane protein 2A | -0.00504529 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | -0.00503776 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00502888 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | -0.00502062 |
| RASA4 | RAS p21 protein activator 4 | -0.00501444 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | -0.00500806 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00500111 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | -0.00499527 |
| SLN | sarcolipin | -0.00499524 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.00499357 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | -0.00498766 |
| ITGA6 | integrin, alpha 6 | -0.0049854 |
| HOMER1 | homer scaffolding protein 1 | -0.00496581 |
| RDX | radixin | -0.00496006 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | -0.00495122 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0049469 |
| TMEM70 | transmembrane protein 70 | -0.00494525 |
| DPT | dermatopontin | -0.0049419 |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | -0.00493873 |
| TFF1 | trefoil factor 1 | -0.00493049 |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | -0.00492986 |
| LAMA2 | laminin, alpha 2 | -0.00492369 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.00492159 |
| MSN | moesin | -0.00492146 |
| MMD | monocyte to macrophage differentiation-associated | -0.00492021 |
| CD93 | CD93 molecule | -0.00491731 |
| MLXIP | MLX interacting protein | -0.00491666 |
| COL21A1 | collagen, type XXI, alpha 1 | -0.00491651 |
| ZNF532 | zinc finger protein 532 | -0.00490125 |
| VEGFA | vascular endothelial growth factor A | -0.0048983 |
| DAZAP1 | DAZ associated protein 1 | -0.00489664 |
| LYZ | lysozyme | -0.00489346 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.00489007 |
| TYMS | thymidylate synthetase | -0.00488956 |
| CAPN6 | calpain 6 | -0.00488008 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | -0.00487576 |
| NTS | neurotensin | -0.00486639 |
| EDNRB | endothelin receptor type B | -0.00486057 |
| TNNC2 | troponin C type 2 (fast) | -0.00485616 |
| SLC35G2 | solute carrier family 35, member G2 | -0.00484803 |
| FAM3C | family with sequence similarity 3, member C | -0.00483981 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.00482127 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.00481372 |
| OTUD3 | OTU deubiquitinase 3 | -0.00480698 |
| MGP | matrix Gla protein | -0.00480457 |
| ARGLU1 | arginine and glutamate rich 1 | -0.00480358 |
| UPF3B | UPF3 regulator of nonsense transcripts homolog B (yeast) | -0.00480295 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.00479306 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | -0.00479064 |
| SNRNP70 | small nuclear ribonucleoprotein 70kDa (U1) | -0.00478353 |
| MPPED2 | metallophosphoesterase domain containing 2 | -0.00477237 |
| APOA2 | apolipoprotein A-II | -0.00477113 |
| GOLM1 | golgi membrane protein 1 | -0.00476946 |
| COL6A2 | collagen, type VI, alpha 2 | -0.00476773 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.00475766 |
| FILIP1L | filamin A interacting protein 1-like | -0.00475291 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00475241 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.00475216 |
| MYO5C | myosin VC | -0.00474913 |
| ZNF217 | zinc finger protein 217 | -0.00474653 |
| PRRX1 | paired related homeobox 1 | -0.00473127 |
| TPM3 | tropomyosin 3 | -0.00472409 |
| SCAMP1 | secretory carrier membrane protein 1 | -0.00471566 |
| KRT8 | keratin 8, type II | -0.00471124 |
| GOLGA8A | golgin A8 family, member A | -0.00470932 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | -0.0047058 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.0047048 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.00469503 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.00468961 |
| C1QB | complement component 1, q subcomponent, B chain | -0.00468156 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00467929 |
| FBXO11 | F-box protein 11 | -0.00466991 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.00466751 |
| RTN2 | reticulon 2 | -0.00466703 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.0046471 |
| KRT18 | keratin 18, type I | -0.00464374 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.00463696 |
| CLDN5 | claudin 5 | -0.00463399 |
| ARL14 | ADP-ribosylation factor-like 14 | -0.00461837 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | -0.00461174 |
| OLFML2B | olfactomedin-like 2B | -0.00460216 |
| OPHN1 | oligophrenin 1 | -0.00459433 |
| MCM7 | minichromosome maintenance complex component 7 | -0.00458814 |
| ELAPOR1 | endosome-lysosome associated apoptosis and autophagy regulator 1 | -0.00458803 |
