CR2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description complement component (3d/Epstein Barr virus) receptor 2|This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 1380)
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Genes

287 genes differentially expressed following the CR2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TRHR thyrotropin-releasing hormone receptor 2.64031
SMIM22 small integral membrane protein 22 2.64031
PTX3 pentraxin 3, long 2.64031
BSX brain-specific homeobox 2.64031
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.64031
KLF1 Kruppel-like factor 1 (erythroid) 2.64031
TACSTD2 tumor-associated calcium signal transducer 2 2.64031
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.64031
LAMP5 lysosomal-associated membrane protein family, member 5 2.64031
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.64031
FCMR Fc fragment of IgM receptor 2.64031
ADTRP androgen-dependent TFPI-regulating protein 2.64031
BNIPL BCL2/adenovirus E1B 19kD interacting protein like 2.64031
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.64031
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.64031
DYDC1 DPY30 domain containing 1 2.64031
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.62788
HINFP histone H4 transcription factor 2.62788
PARP3 poly (ADP-ribose) polymerase family, member 3 2.62788
OSGIN1 oxidative stress induced growth inhibitor 1 2.62788
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.62788
GLUD2 glutamate dehydrogenase 2 2.62788
ZNF492 zinc finger protein 492 2.62788
ZEB2 zinc finger E-box binding homeobox 2 2.62788
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.62788
FGL2 fibrinogen-like 2 2.62788
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.62788
ADGRE3 adhesion G protein-coupled receptor E3 2.62788
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.62788
CLEC19A C-type lectin domain family 19, member A 2.62788
MTTP microsomal triglyceride transfer protein 2.62788
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.62788
ATOH7 atonal homolog 7 (Drosophila) 2.62788
AVP arginine vasopressin 2.62788
MPL MPL proto-oncogene, thrombopoietin receptor 2.62788
SPACA4 sperm acrosome associated 4 2.62788
PRR29 proline rich 29 2.62788
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.62788
ACRBP acrosin binding protein 2.62788
ACVRL1 activin A receptor type II-like 1 2.62788
GMFG glia maturation factor, gamma 2.62788
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.62788
PDE7B phosphodiesterase 7B 2.62788
APOA2 apolipoprotein A-II 2.62788
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.62788
TUBB8 tubulin, beta 8 class VIII 2.62788
TLX2 T-cell leukemia homeobox 2 2.62788
C12ORF71 chromosome 12 open reading frame 71 2.62788
ANKRD34A ankyrin repeat domain 34A 2.62788
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.62788
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 2.62788
CATSPERT catsper channel auxiliary subunit tau 2.62788
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.62788
ROPN1B rhophilin associated tail protein 1B 2.62788
SCEL sciellin 2.62788
MYH1 myosin, heavy chain 1, skeletal muscle, adult 2.62788
CXCL13 chemokine (C-X-C motif) ligand 13 2.62788
SPI1 Spi-1 proto-oncogene 2.62788
MYPN myopalladin 2.62788
VEGFD vascular endothelial growth factor D 2.62788
SEPTIN14 septin 14 2.62788
ACP3 acid phosphatase 3 2.62788
GRAMD2A GRAM domain containing 2A 2.62788
SPEGNB SPEG neighbor 2.62788
LOC124902436 talanin 2.62788
GREP1 glycine rich extracellular protein 1 2.62788
GLYATL1B glycine-N-acyltransferase like 1B 2.62788
SEPTIN12 septin 12 2.62788
FREY1 Frey regulator of sperm-oocyte fusion 1 2.62788
VXN vexin 2.62788
PLPP4 phospholipid phosphatase 4 2.62788
CLEC6A C-type lectin domain family 6, member A 2.62788
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.62788
SLC22A10 solute carrier family 22, member 10 2.62788
NRN1 neuritin 1 2.62788
NHP2 NHP2 ribonucleoprotein 2.62788
NDRG1 N-myc downstream regulated 1 2.62788
SMOC2 SPARC related modular calcium binding 2 2.62788
OR5H2 olfactory receptor, family 5, subfamily H, member 2 2.62788
SIX2 SIX homeobox 2 2.62788
CCKAR cholecystokinin A receptor 2.62788
RAET1G retinoic acid early transcript 1G 2.62788
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.62788
LIPF lipase, gastric 2.62788
DLK1 delta-like 1 homolog (Drosophila) 2.62788
LRRC72 leucine rich repeat containing 72 2.62788
OR2D3 olfactory receptor, family 2, subfamily D, member 3 2.62788
VCX3A variable charge, X-linked 3A 2.62788
C6ORF118 chromosome 6 open reading frame 118 2.62788
CLDN9 claudin 9 2.62788
PCDHA2 protocadherin alpha 2 2.62788
ACOT4 acyl-CoA thioesterase 4 2.62788
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.62788
TPRX1 tetra-peptide repeat homeobox 1 2.62788
AGR3 anterior gradient 3 2.62788
TNR tenascin R 2.62788
S100A14 S100 calcium binding protein A14 2.62788
CLRN2 clarin 2 2.62788
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 2.62788
KLF2 Kruppel-like factor 2 2.62788
WFDC5 WAP four-disulfide core domain 5 2.62788
GOLGA6B golgin A6 family, member B 2.62788
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.62788
ZNF541 zinc finger protein 541 2.62788
SMKR1 small lysine-rich protein 1 2.62788
TCF21 transcription factor 21 2.62788
MORC1 MORC family CW-type zinc finger 1 2.62788
SLC25A52 solute carrier family 25, member 52 2.62788
SPTBN5 spectrin, beta, non-erythrocytic 5 2.62788
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.62788
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.62788
MR1 major histocompatibility complex, class I-related 2.62788
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.62788
TREH trehalase (brush-border membrane glycoprotein) 2.62788
CDH19 cadherin 19, type 2 2.62788
IL36R interleukin 36 receptor 2.62788
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.62788
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.62788
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.62788
RGS4 regulator of G-protein signaling 4 2.62788
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.62788
MYADML2 myeloid-associated differentiation marker-like 2 2.62788
KLHDC1 kelch domain containing 1 2.62788
WNT10B wingless-type MMTV integration site family, member 10B 2.62788
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.62788
C20ORF144 chromosome 20 open reading frame 144 2.62788
SMR3B submaxillary gland androgen regulated protein 3B 2.62788
NUPR1 nuclear protein, transcriptional regulator, 1 2.62788
EVPLL envoplakin-like 2.62788
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.62788
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) 2.62788
SEC14L3 SEC14-like 3 (S. cerevisiae) 2.62788
CHI3L2 chitinase 3-like 2 2.62788
FBXO40 F-box protein 40 2.62788
ZPBP zona pellucida binding protein 2.62788
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.62788
CCDC160 coiled-coil domain containing 160 2.62788
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.62788
LPA lipoprotein, Lp(a) 2.62788
TMPRSS15 transmembrane protease, serine 15 2.62788
TEX38 testis expressed 38 2.62788
FRMPD1 FERM and PDZ domain containing 1 2.62788
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.62788
PADI1 peptidyl arginine deiminase, type I 2.62788
ADAM20 ADAM metallopeptidase domain 20 2.62788
STOML3 stomatin (EPB72)-like 3 2.62788
MYOZ2 myozenin 2 2.62788
ZNF648 zinc finger protein 648 2.62788
JAM2 junctional adhesion molecule 2 2.62788
ANKRD30B ankyrin repeat domain 30B 2.62788
TMEM45B transmembrane protein 45B 2.62788
EPX eosinophil peroxidase 2.62788
CARNS1 carnosine synthase 1 2.62788
LST1 leukocyte specific transcript 1 2.62788
PATE2 prostate and testis expressed 2 2.62788
SLC30A10 solute carrier family 30, member 10 2.62788
GPBAR1 G protein-coupled bile acid receptor 1 2.62788
MT1M metallothionein 1M 2.62788
TDRD10 tudor domain containing 10 2.62788
MAPK11 mitogen-activated protein kinase 11 2.62788
ITLN2 intelectin 2 2.59548
FANCD2 Fanconi anemia, complementation group D2 2.54045
GLRB glycine receptor, beta 2.48482
JAKMIP1 janus kinase and microtubule interacting protein 1 2.48482
RND1 Rho family GTPase 1 2.48264
TMEM35B transmembrane protein 35B 2.4664
RSL24D1 ribosomal L24 domain containing 1 2.44226
PECR peroxisomal trans-2-enoyl-CoA reductase 2.43642
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.42952
TMEM187 transmembrane protein 187 2.3892
EPCAM epithelial cell adhesion molecule 2.35793
MAP2K1 mitogen-activated protein kinase kinase 1 2.33923
FOXN4 forkhead box N4 2.33393
NLRP2 NLR family, pyrin domain containing 2 2.32816
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 2.31348
HHIPL2 HHIP-like 2 2.29878
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 2.29878
CYSLTR1 cysteinyl leukotriene receptor 1 2.29878
PER3 period circadian clock 3 2.28733
M1AP meiosis 1 associated protein 2.28153
MED10 mediator complex subunit 10 2.27887
TUBD1 tubulin, delta 1 2.27471
SNX22 sorting nexin 22 2.27468
RHEBL1 Ras homolog enriched in brain like 1 2.27127
ZNF883 zinc finger protein 883 2.23587
STAU2 staufen double-stranded RNA binding protein 2 2.23173
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.20732
SIRAL1 SIR2 antiphage like 1 2.18927
SERTAD1 SERTA domain containing 1 2.1693
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 2.15643
MTMR9 myotubularin related protein 9 2.0775
RADIL Ras association and DIL domains 2.05768
LAMB2 laminin, beta 2 (laminin S) 2.05739
TVP23C trans-golgi network vesicle protein 23 homolog C (S. cerevisiae) 2.05707
TUBB4A tubulin, beta 4A class IVa 2.03453
C19ORF44 chromosome 19 open reading frame 44 2.03423
ZNF324 zinc finger protein 324 2.01098
HES1 hes family bHLH transcription factor 1 2.00743
NISCH nischarin 2.00709

decreased expression

Symbol Name Standardized Value
RBP5 retinol binding protein 5, cellular -2.64031
ISM2 isthmin 2 -2.64031
NCR1 natural cytotoxicity triggering receptor 1 -2.64031
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -2.64031
KEL Kell blood group, metallo-endopeptidase -2.64031
HSH2D hematopoietic SH2 domain containing -2.64031
DYNLT5 dynein light chain Tctex-type family member 5 -2.64031
UPK2 uroplakin 2 -2.64031
AGA-DT AGA divergent transcript -2.62788
EBF3 early B-cell factor 3 -2.62788
CAPN11 calpain 11 -2.62788
ZBED6 zinc finger, BED-type containing 6 -2.62788
TGM2 transglutaminase 2 -2.62788
IL31RA interleukin 31 receptor A -2.62788
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -2.62788
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) -2.62788
ECT2L epithelial cell transforming 2 like -2.62788
PTK6 protein tyrosine kinase 6 -2.62788
EGFLAM EGF-like, fibronectin type III and laminin G domains -2.62788
JAG2 jagged 2 -2.62788
CR2 complement component (3d/Epstein Barr virus) receptor 2 -2.62788
LYNX1 Ly6/neurotoxin 1 -2.62788
PGA5 pepsinogen 5, group I (pepsinogen A) -2.62788
OR2A14 olfactory receptor, family 2, subfamily A, member 14 -2.62788
UPK1B uroplakin 1B -2.62788
GPRC6A G protein-coupled receptor, class C, group 6, member A -2.62788
CFAP141 cilia and flagella associated protein 141 -2.62788
HMGB4 high mobility group box 4 -2.62788
GPHA2 glycoprotein hormone alpha 2 -2.62788
DNAI3 dynein axonemal intermediate chain 3 -2.62788
ARHGAP42 Rho GTPase activating protein 42 -2.62788
CFAP100 cilia and flagella associated protein 100 -2.62788
CFAP47 cilia and flagella associated protein 47 -2.62788
CADPS2 Ca++-dependent secretion activator 2 -2.62788
BEST4 bestrophin 4 -2.62788
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 -2.62788
PROZ protein Z, vitamin K-dependent plasma glycoprotein -2.62788
BGN biglycan -2.62788
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -2.62788
ARC activity-regulated cytoskeleton-associated protein -2.5882
C4ORF33 chromosome 4 open reading frame 33 -2.56939
MXRA8 matrix-remodelling associated 8 -2.56842
PNPLA5 patatin-like phospholipase domain containing 5 -2.50069
TUBA1A tubulin, alpha 1a -2.48482
KIAA0319 KIAA0319 -2.48239
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.47342
DNAI4 dynein axonemal intermediate chain 4 -2.47203
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -2.44209
FGF1 fibroblast growth factor 1 (acidic) -2.42896
RNF181 ring finger protein 181 -2.40781
GATAD2A GATA zinc finger domain containing 2A -2.40781
NEK7 NIMA-related kinase 7 -2.40597
SCN4A sodium channel, voltage gated, type IV alpha subunit -2.37463
FBLL1 fibrillarin-like 1 -2.37463
CDH12 cadherin 12, type 2 (N-cadherin 2) -2.37463
LIAS lipoic acid synthetase -2.30924
NQO2 NAD(P)H dehydrogenase, quinone 2 -2.30776
CCNE2 cyclin E2 -2.29878
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 -2.29878
RAB1A RAB1A, member RAS oncogene family -2.28345
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.28153
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 -2.28153
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -2.27848
IST1 increased sodium tolerance 1 homolog (yeast) -2.27199
TCTN3 tectonic family member 3 -2.25842
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.23972
STK36 serine/threonine kinase 36 -2.21782
SCART1 scavenger receptor protein family member -2.20463
C16ORF86 chromosome 16 open reading frame 86 -2.20463
TRAIP TRAF interacting protein -2.19513
COL6A1 collagen, type VI, alpha 1 -2.19273
ZNF233 zinc finger protein 233 -2.19273
HFE hemochromatosis -2.18947
SYNPO synaptopodin -2.18947
EFNA3 ephrin-A3 -2.1693
HYKK hydroxylysine kinase -2.15774
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) -2.15584
DPP4 dipeptidyl-peptidase 4 -2.1519
TOMM70 translocase of outer mitochondrial membrane 70 -2.13549
PYCR3 pyrroline-5-carboxylate reductase 3 -2.13476
ZNF230 zinc finger protein 230 -2.10044
HJURP Holliday junction recognition protein -2.09559
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 -2.09559
ZSCAN25 zinc finger and SCAN domain containing 25 -2.09002
RCAN3 RCAN family member 3 -2.09002
SCML1 sex comb on midleg-like 1 (Drosophila) -2.08799
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -2.03557
RNF103 ring finger protein 103 -2.00137