CRCGN008_HEPG2_24H:A06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

323 genes differentially expressed following the CRCGN008_HEPG2_24H:A06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 10.0
ADRB2 adrenoceptor beta 2, surface 5.59425
MYLK myosin light chain kinase 5.2591
TATDN2 TatD DNase domain containing 2 5.19465
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.15545
EPHB2 EPH receptor B2 5.13987
TAC4 tachykinin 4 (hemokinin) 5.0
HLA-DMA major histocompatibility complex, class II, DM alpha 4.89595
LOC122526780 uncharacterized LOC122526780 4.7948
PLS1 plastin 1 4.5467
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 4.48467
SNAP25 synaptosomal-associated protein, 25kDa 4.3532
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 4.28825
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.93782
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.93235
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.92655
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 3.83593
VGLL4 vestigial-like family member 4 3.79967
DYNLT3 dynein, light chain, Tctex-type 3 3.7744
PHKG2 phosphorylase kinase, gamma 2 (testis) 3.72655
KLHL9 kelch-like family member 9 3.62678
TIAM1 T-cell lymphoma invasion and metastasis 1 3.62605
CHN1 chimerin 1 3.38845
KAT2B K(lysine) acetyltransferase 2B 3.3369
EPHA3 EPH receptor A3 3.20002
JADE2 jade family PHD finger 2 3.19948
PRR15L proline rich 15-like 3.0919
NOTCH1 notch 1 2.9658
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 2.9453
NNT nicotinamide nucleotide transhydrogenase 2.92785
TBX2 T-box 2 2.90448
ARFIP2 ADP-ribosylation factor interacting protein 2 2.89725
MED24 mediator complex subunit 24 2.8859
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.8806
DPEP1 dipeptidase 1 (renal) 2.86215
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.8592
ASCC3 activating signal cointegrator 1 complex subunit 3 2.8583
RAB15 RAB15, member RAS oncogene family 2.85092
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.82535
DROSHA drosha, ribonuclease type III 2.79535
DCHS2 dachsous cadherin-related 2 2.793
COL9A2 collagen, type IX, alpha 2 2.7847
PYCR1 pyrroline-5-carboxylate reductase 1 2.72995
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.6896
WNT3 wingless-type MMTV integration site family, member 3 2.6638
GALE UDP-galactose-4-epimerase 2.6421
CER1 cerberus 1, DAN family BMP antagonist 2.6349
GNRH2 gonadotropin-releasing hormone 2 2.6246
ARID3A AT rich interactive domain 3A (BRIGHT-like) 2.6121
NT5DC2 5'-nucleotidase domain containing 2 2.60325
CASC3 cancer susceptibility candidate 3 2.6027
CAPN10 calpain 10 2.6006
TXNL4B thioredoxin-like 4B 2.6004
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.5953
HIP1 huntingtin interacting protein 1 2.59355
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 2.58926
GRM2 glutamate receptor, metabotropic 2 2.58605
SLC22A14 solute carrier family 22, member 14 2.58115
TAC3 tachykinin 3 2.5803
CDX1 caudal type homeobox 1 2.57185
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.56705
BFSP2 beaded filament structural protein 2, phakinin 2.56035
TPSG1 tryptase gamma 1 2.54975
LGMN legumain 2.5496
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.54947
CDX4 caudal type homeobox 4 2.54765
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 2.5419
CABP5 calcium binding protein 5 2.53755
EVL Enah/Vasp-like 2.531
FBXO31 F-box protein 31 2.5308
GPR68 G protein-coupled receptor 68 2.49445
CDON cell adhesion associated, oncogene regulated 2.48695
DENND2A DENN/MADD domain containing 2A 2.48623
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 2.477
CCL24 chemokine (C-C motif) ligand 24 2.47595
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.46355
OSBP2 oxysterol binding protein 2 2.4561
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 2.45507
PITPNM3 PITPNM family member 3 2.454
CHERP calcium homeostasis endoplasmic reticulum protein 2.4508
CCP110 centriolar coiled coil protein 110kDa 2.4501
NANOS2 nanos homolog 2 (Drosophila) 2.4496
LOC102725023 killer cell immunoglobulin-like receptor 2DS3 allele 0020101 2.4435
CDK19 cyclin-dependent kinase 19 2.43842
ZBTB7B zinc finger and BTB domain containing 7B 2.4232
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.42318
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 2.42005
PDE7B phosphodiesterase 7B 2.4183
ASXL3 additional sex combs like transcriptional regulator 3 2.41545
CYCS cytochrome c, somatic 2.4116
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.39305
INTS3 integrator complex subunit 3 2.3906
DONSON downstream neighbor of SON 2.38745
BPGM 2,3-bisphosphoglycerate mutase 2.38335
MTNR1B melatonin receptor 1B 2.38335
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 2.3561
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 2.35105
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.3488
TMEM120B transmembrane protein 120B 2.34715
CRYBA4 crystallin, beta A4 2.346
INCENP inner centromere protein antigens 135/155kDa 2.346
LCN1 lipocalin 1 2.3381
GUCY2C guanylate cyclase 2C 2.3359
PHF2 PHD finger protein 2 2.3353
TREH trehalase (brush-border membrane glycoprotein) 2.33225
POU3F3 POU class 3 homeobox 3 2.32935
SNAI1 snail family zinc finger 1 2.32875
PGAM4 phosphoglycerate mutase family member 4 2.3266
PIH1D1 PIH1 domain containing 1 2.32625
CEP112 centrosomal protein 112kDa 2.31905
GCGR glucagon receptor 2.3181
NUP133 nucleoporin 133kDa 2.3179
ANKH ANKH inorganic pyrophosphate transport regulator 2.3096
COL11A2 collagen, type XI, alpha 2 2.305
PRDM11 PR domain containing 11 2.3049
PTGDR2 prostaglandin D2 receptor 2 2.30072
FGF22 fibroblast growth factor 22 2.2983
GOLGA6B golgin A6 family, member B 2.29645
ZFP37 ZFP37 zinc finger protein 2.28665
ASIC1 acid sensing (proton gated) ion channel 1 2.28662
S1PR5 sphingosine-1-phosphate receptor 5 2.2816
IL13 interleukin 13 2.2812
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2.2792
ANGPT4 angiopoietin 4 2.27035
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.25795
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 2.25385
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.25185
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.2514
KLRD1 killer cell lectin-like receptor subfamily D, member 1 2.25102
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 2.25072
SSBP2 single-stranded DNA binding protein 2 2.24953
AMDHD2 amidohydrolase domain containing 2 2.2474
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) 2.24635
ZNRF4 zinc and ring finger 4 2.2332
PACC1 proton activated chloride channel 1 2.23245
RAB31 RAB31, member RAS oncogene family 2.2321
REEP2 receptor accessory protein 2 2.2293
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.2287
ACTN3 actinin, alpha 3 (gene/pseudogene) 2.22695
SCRN1 secernin 1 2.2262
KRT76 keratin 76, type II 2.2223
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 2.21955
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.21828
RALGDS ral guanine nucleotide dissociation stimulator 2.21703
MBD4 methyl-CpG binding domain protein 4 2.21668
DCAF4 DDB1 and CUL4 associated factor 4 2.21395
KCTD7 potassium channel tetramerization domain containing 7 2.21305
NME8 NME/NM23 family member 8 2.2109
DOK3 docking protein 3 2.21065
HOXB1 homeobox B1 2.20975
CSH2 chorionic somatomammotropin hormone 2 2.2015
DEFA6 defensin, alpha 6, Paneth cell-specific 2.1955
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.1905
IL12RB1 interleukin 12 receptor, beta 1 2.1859
LBX1 ladybird homeobox 1 2.18175
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 2.1814
NOSIP nitric oxide synthase interacting protein 2.18135
MYH13 myosin, heavy chain 13, skeletal muscle 2.17715
CD160 CD160 molecule 2.17365
COL9A1 collagen, type IX, alpha 1 2.17205
CFAP74 cilia and flagella associated protein 74 2.16988
OVGP1 oviductal glycoprotein 1, 120kDa 2.16735
GH1 growth hormone 1 2.16349
RDH8 retinol dehydrogenase 8 (all-trans) 2.15885
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 2.15825
DGKQ diacylglycerol kinase, theta 110kDa 2.15815
PROP1 PROP paired-like homeobox 1 2.1579
ZNF821 zinc finger protein 821 2.156
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.15575
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.15445
COLGALT2 collagen beta(1-O)galactosyltransferase 2 2.1529
ERN1 endoplasmic reticulum to nucleus signaling 1 2.151
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) 2.14995
PAX7 paired box 7 2.1476
RCVRN recoverin 2.14695
HOXA11 homeobox A11 2.14415
NHERF4 NHERF family PDZ scaffold protein 4 2.14265
DUSP28 dual specificity phosphatase 28 2.1405
CREG1 cellular repressor of E1A-stimulated genes 1 2.14015
KCNK13 potassium channel, two pore domain subfamily K, member 13 2.1381
NPC1L1 NPC1-like 1 2.13735
SPTB spectrin, beta, erythrocytic 2.1336
CHRM4 cholinergic receptor, muscarinic 4 2.13035
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) 2.13025
KDM7A lysine (K)-specific demethylase 7A 2.12995
NTN3 netrin 3 2.1294
TBX19 T-box 19 2.12855
GTF2IRD1 GTF2I repeat domain containing 1 2.1192
FAM76A family with sequence similarity 76, member A 2.11905
PMFBP1 polyamine modulated factor 1 binding protein 1 2.1157
RAB26 RAB26, member RAS oncogene family 2.11548
IL24 interleukin 24 2.11025
OMP olfactory marker protein 2.1055
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.10435
TACR3 tachykinin receptor 3 2.10385
BCL7C B-cell CLL/lymphoma 7C 2.10115
PRODH2 proline dehydrogenase (oxidase) 2 2.1008
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.10015
AURKC aurora kinase C 2.0954
NCR1 natural cytotoxicity triggering receptor 1 2.0912
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 2.09085
FOXH1 forkhead box H1 2.09075
ALX3 ALX homeobox 3 2.08475
AP3D1 adaptor-related protein complex 3, delta 1 subunit 2.08438
MCHR1 melanin-concentrating hormone receptor 1 2.082
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 2.08045
SCRT1 scratch family zinc finger 1 2.07925
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 2.07815
ZSCAN5A zinc finger and SCAN domain containing 5A 2.07665
AGBL5 ATP/GTP binding protein-like 5 2.07315
NEUROG2 neurogenin 2 2.07185
LRRC3 leucine rich repeat containing 3 2.0669
FGF16 fibroblast growth factor 16 2.065
ADM2 adrenomedullin 2 2.06405
POM121L2 POM121 transmembrane nucleoporin-like 2 2.0582
LOC102723996 ICOS ligand 2.05772
DNASE2B deoxyribonuclease II beta 2.05455
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.05325
BTBD2 BTB (POZ) domain containing 2 2.0516
SLC66A3 solute carrier family 66 member 3 2.05145
NEUROD4 neuronal differentiation 4 2.0457
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2.04112
DPYSL4 dihydropyrimidinase-like 4 2.04075
CCL1 chemokine (C-C motif) ligand 1 2.04025
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 2.0359
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 2.0344
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 2.0341
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 2.03253
DCC DCC netrin 1 receptor 2.03015
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.0298
ACAN aggrecan 2.0267
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 2.0257
KDM8 lysine (K)-specific demethylase 8 2.02515
CCDC70 coiled-coil domain containing 70 2.02505
STRN striatin, calmodulin binding protein 2.02082
TMEM265 transmembrane protein 265 2.0204
TMEM143 transmembrane protein 143 2.02035
CDK3 cyclin-dependent kinase 3 2.01525
HRC histidine rich calcium binding protein 2.0151
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.0142
CCDC86 coiled-coil domain containing 86 2.0136
AQP6 aquaporin 6, kidney specific 2.01303
NEU3 sialidase 3 (membrane sialidase) 2.01192
LIN7B lin-7 homolog B (C. elegans) 2.0116
SHB Src homology 2 domain containing adaptor protein B 2.00872
MC3R melanocortin 3 receptor 2.0085
GNPAT glyceronephosphate O-acyltransferase 2.0082
EFR3B EFR3 homolog B (S. cerevisiae) 2.00515
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.00385
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.0022
DNAH17 dynein, axonemal, heavy chain 17 2.00105
ZNF280A zinc finger protein 280A 2.00105

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -8.33305
LDHD lactate dehydrogenase D -4.776
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.7229
CD320 CD320 molecule -4.4175
FASTKD5 FAST kinase domains 5 -4.3256
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -4.1708
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.57065
TES testin LIM domain protein -3.54952
CTNND1 catenin (cadherin-associated protein), delta 1 -3.46188
SCAND1 SCAN domain containing 1 -3.4516
EAPP E2F-associated phosphoprotein -3.43745
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.39483
SMIM40 small integral membrane protein 40 -3.31305
KIFBP kinesin family binding protein -3.1982
FGFR4 fibroblast growth factor receptor 4 -3.13938
LRRC41 leucine rich repeat containing 41 -3.13552
GOLT1B golgi transport 1B -3.10605
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.9761
CCNH cyclin H -2.96995
DDIT4 DNA-damage-inducible transcript 4 -2.96605
TBC1D15 TBC1 domain family, member 15 -2.96175
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.9505
JADE3 jade family PHD finger 3 -2.9133
CRYZ crystallin, zeta (quinone reductase) -2.8797
SNX11 sorting nexin 11 -2.79052
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.7578
ARHGAP29 Rho GTPase activating protein 29 -2.73455
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.72365
MTFR1 mitochondrial fission regulator 1 -2.70823
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.62705
SPDEF SAM pointed domain containing ETS transcription factor -2.56108
ENOPH1 enolase-phosphatase 1 -2.557
MARCHF5 membrane associated ring-CH-type finger 5 -2.54105
OXA1L oxidase (cytochrome c) assembly 1-like -2.5069
HYOU1 hypoxia up-regulated 1 -2.42805
NUP93 nucleoporin 93kDa -2.4197
ANXA7 annexin A7 -2.3876
YIPF6 Yip1 domain family, member 6 -2.34978
PEX3 peroxisomal biogenesis factor 3 -2.34648
PRCP prolylcarboxypeptidase (angiotensinase C) -2.3383
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine -2.3362
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 -2.30355
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -2.2327
MORC4 MORC family CW-type zinc finger 4 -2.23125
PLSCR4 phospholipid scramblase 4 -2.21395
RXYLT1 ribitol xylosyltransferase 1 -2.21245
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.20975
YAP1 Yes-associated protein 1 -2.1921
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.1909
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.18477
MAGT1 magnesium transporter 1 -2.16785
HCCS holocytochrome c synthase -2.16663
F2RL1 coagulation factor II (thrombin) receptor-like 1 -2.16537
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.16245
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.16
TMEM126B transmembrane protein 126B -2.14805
PALM2AKAP2 PALM2 and AKAP2 fusion -2.1418
MACIR macrophage immunometabolism regulator -2.11745
TMSB10 thymosin beta 10 -2.08695
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.07095
PLIN2 perilipin 2 -2.06455
LEPROTL1 leptin receptor overlapping transcript-like 1 -2.06017
CUTC cutC copper transporter -2.0448
ZW10 zw10 kinetochore protein -2.0442
DLAT dihydrolipoamide S-acetyltransferase -2.04188
NPY1R neuropeptide Y receptor Y1 -2.04145
RHOG ras homolog family member G -2.03495
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 -2.02588
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -2.01022
G0S2 G0/G1 switch 2 -2.00265
NCK2 NCK adaptor protein 2 -2.0012