CRCGN008_HEPG2_24H:A07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,6-dinitrotoluene 39.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

202 genes differentially expressed following the CRCGN008_HEPG2_24H:A07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 10.0
CBR3 carbonyl reductase 3 8.8905
E2F2 E2F transcription factor 2 7.34345
BACE2 beta-site APP-cleaving enzyme 2 6.65375
MSRA methionine sulfoxide reductase A 5.8557
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.81685
CAPN1 calpain 1, (mu/I) large subunit 5.7438
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.6516
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.36345
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.34975
ADGRE5 adhesion G protein-coupled receptor E5 5.3385
DYNLT3 dynein, light chain, Tctex-type 3 5.18115
ALDOC aldolase C, fructose-bisphosphate 5.0565
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.7643
PLS1 plastin 1 4.6003
UBQLN2 ubiquilin 2 4.36905
ARL4C ADP-ribosylation factor-like 4C 4.36362
CCDC92 coiled-coil domain containing 92 4.3085
TIAM1 T-cell lymphoma invasion and metastasis 1 4.11415
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.88925
C2CD2 C2 calcium-dependent domain containing 2 3.8854
SQOR sulfide quinone oxidoreductase 3.5657
GATA3 GATA binding protein 3 3.49362
STAT5B signal transducer and activator of transcription 5B 3.43945
NENF neudesin neurotrophic factor 3.371
SPTAN1 spectrin, alpha, non-erythrocytic 1 3.12635
UBE2A ubiquitin-conjugating enzyme E2A 3.11825
PEX11A peroxisomal biogenesis factor 11 alpha 3.0118
CSK c-src tyrosine kinase 2.9016
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.89773
MTERF3 mitochondrial transcription termination factor 3 2.87925
CCL2 chemokine (C-C motif) ligand 2 2.86915
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.74653
PEPD peptidase D 2.721
BPHL biphenyl hydrolase-like (serine hydrolase) 2.7153
HLA-DMA major histocompatibility complex, class II, DM alpha 2.695
SSBP2 single-stranded DNA binding protein 2 2.69085
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.6765
LAGE3 L antigen family, member 3 2.6727
TBP TATA box binding protein 2.6229
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.5148
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.39985
PMM2 phosphomannomutase 2 2.3263
EHBP1L1 EH domain binding protein 1-like 1 2.24607
KLHDC2 kelch domain containing 2 2.20655
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.18195
PLSCR3 phospholipid scramblase 3 2.14878
DAZAP1 DAZ associated protein 1 2.12215
SATB1 SATB homeobox 1 2.0829
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2.0606
MYLIP myosin regulatory light chain interacting protein 2.0595
CYCS cytochrome c, somatic 2.02415
PRKDC protein kinase, DNA-activated, catalytic polypeptide 2.017
LOC122526780 uncharacterized LOC122526780 2.0048

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -6.0082
COG7 component of oligomeric golgi complex 7 -5.91195
RPS5 ribosomal protein S5 -5.84375
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.46975
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.3741
LDHD lactate dehydrogenase D -4.91325
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.85895
PCNA proliferating cell nuclear antigen -4.77245
INPP1 inositol polyphosphate-1-phosphatase -4.65515
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.34505
NGRN neugrin, neurite outgrowth associated -4.26215
TOR1A torsin family 1, member A (torsin A) -3.96578
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.7913
GNAS GNAS complex locus -3.54876
DDIT4 DNA-damage-inducible transcript 4 -3.4664
SNCA synuclein, alpha (non A4 component of amyloid precursor) -3.45627
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.3782
PECR peroxisomal trans-2-enoyl-CoA reductase -3.33425
CAB39 calcium binding protein 39 -3.2198
SCAND1 SCAN domain containing 1 -3.17905
SAR1B secretion associated, Ras related GTPase 1B -3.137
RPS12 ribosomal protein S12 -3.10945
ASCC1 activating signal cointegrator 1 complex subunit 1 -3.07505
ZMIZ1 zinc finger, MIZ-type containing 1 -3.06805
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.04175
CCNB1 cyclin B1 -3.04105
IFT52 intraflagellar transport 52 -2.93465
RPS19 ribosomal protein S19 -2.88588
COMMD1 copper metabolism (Murr1) domain containing 1 -2.85425
RPL18 ribosomal protein L18 -2.84405
RPS29 ribosomal protein S29 -2.80765
RPS24 ribosomal protein S24 -2.80015
RPL26L1 ribosomal protein L26-like 1 -2.76365
RPS4X ribosomal protein S4, X-linked -2.7401
RPL9 ribosomal protein L9 -2.7026
LAMP5 lysosomal-associated membrane protein family, member 5 -2.6905
RPS3A ribosomal protein S3A -2.66402
MRPL33 mitochondrial ribosomal protein L33 -2.65405
POLL polymerase (DNA directed), lambda -2.6385
RPS17 ribosomal protein S17 -2.63283
RPL29 ribosomal protein L29 -2.62943
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -2.62835
RPS11 ribosomal protein S11 -2.6122
RPS18 ribosomal protein S18 -2.56445
RPL23A ribosomal protein L23a -2.55464
RPL41 ribosomal protein L41 -2.55085
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.54575
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 -2.51095
TXNDC9 thioredoxin domain containing 9 -2.51065
RPS16 ribosomal protein S16 -2.49717
OXA1L oxidase (cytochrome c) assembly 1-like -2.49465
RPS10 ribosomal protein S10 -2.49458
PRIM1 primase, DNA, polypeptide 1 (49kDa) -2.46445
PPP4C protein phosphatase 4, catalytic subunit -2.45345
SESN1 sestrin 1 -2.4426
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.43195
PPP1R16B protein phosphatase 1, regulatory subunit 16B -2.4082
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.40665
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) -2.4058
TPT1 tumor protein, translationally-controlled 1 -2.39997
RNF2 ring finger protein 2 -2.38815
RPS15A ribosomal protein S15a -2.3837
ACSM5 acyl-CoA synthetase medium-chain family member 5 -2.3806
VLDLR very low density lipoprotein receptor -2.3736
TEP1 telomerase-associated protein 1 -2.3642
RPL13A ribosomal protein L13a -2.36031
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.3576
SLC35A5 solute carrier family 35, member A5 -2.3559
RPLP1 ribosomal protein, large, P1 -2.35065
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.3434
TULP1 tubby like protein 1 -2.3312
GOLT1B golgi transport 1B -2.32955
RPS13 ribosomal protein S13 -2.3276
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -2.3132
FAM246A family with sequence similarity 246 member A -2.30345
RPL7A ribosomal protein L7a -2.2992
AK6 adenylate kinase 6 -2.2879
PALB2 partner and localizer of BRCA2 -2.2809
PLIN3 perilipin 3 -2.2804
TASL TLR adaptor interacting with endolysosomal SLC15A4 -2.27575
RAP1A RAP1A, member of RAS oncogene family -2.2709
UFSP2 UFM1-specific peptidase 2 -2.2691
GMFG glia maturation factor, gamma -2.26815
COX7B cytochrome c oxidase subunit VIIb -2.2621
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 -2.2555
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -2.25265
RPS7 ribosomal protein S7 -2.24498
GTPBP8 GTP-binding protein 8 (putative) -2.2377
RPS21 ribosomal protein S21 -2.2338
RPS23 ribosomal protein S23 -2.2314
TEX10 testis expressed 10 -2.22705
RPL39 ribosomal protein L39 -2.22665
NOTCH4 notch 4 -2.2173
POMT2 protein-O-mannosyltransferase 2 -2.20805
RPL12 ribosomal protein L12 -2.20353
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.1996
KDM3A lysine (K)-specific demethylase 3A -2.19655
RPLP2 ribosomal protein, large, P2 -2.19595
TAOK1 TAO kinase 1 -2.1945
RPL10A ribosomal protein L10a -2.1934
FOXJ3 forkhead box J3 -2.18827
CLDN5 claudin 5 -2.18655
RPL32 ribosomal protein L32 -2.1807
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 -2.1694
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) -2.16477
LAPTM5 lysosomal protein transmembrane 5 -2.15675
RPL27A ribosomal protein L27a -2.1514
CD163L1 CD163 molecule-like 1 -2.15105
DBF4B DBF4 zinc finger B -2.1481
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.1464
RPL3 ribosomal protein L3 -2.14358
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -2.1399
PLVAP plasmalemma vesicle associated protein -2.1398
SH3D19 SH3 domain containing 19 -2.1396
RPLP0 ribosomal protein, large, P0 -2.13116
PLAG1 pleiomorphic adenoma gene 1 -2.12945
UBC ubiquitin C -2.12908
RANBP17 RAN binding protein 17 -2.1224
ERCC1 excision repair cross-complementation group 1 -2.1216
TCTN3 tectonic family member 3 -2.11005
SLC12A8 solute carrier family 12, member 8 -2.1092
PIH1D1 PIH1 domain containing 1 -2.1037
RPL17-C18ORF32 RPL17-C18orf32 readthrough -2.10006
HSPA6 heat shock 70kDa protein 6 (HSP70B') -2.0966
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 -2.0949
EIF3I eukaryotic translation initiation factor 3, subunit I -2.09455
XYLT1 xylosyltransferase I -2.09185
RPS27A ribosomal protein S27a -2.0887
GINS4 GINS complex subunit 4 (Sld5 homolog) -2.08145
TP53TG5 TP53 target 5 -2.07515
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 -2.07115
DCTN5 dynactin 5 (p25) -2.06835
NPR1 natriuretic peptide receptor 1 -2.06273
BABAM2 BRISC and BRCA1 A complex member 2 -2.06208
RPL27 ribosomal protein L27 -2.0572
TWF2 twinfilin actin binding protein 2 -2.04645
MYH15 myosin, heavy chain 15 -2.0408
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -2.03602
PHAF1 phagosome assembly factor 1 -2.03545
SSR4 signal sequence receptor, delta -2.03275
GLB1L galactosidase, beta 1-like -2.02855
CD70 CD70 molecule -2.02665
RPL14 ribosomal protein L14 -2.02215
HDAC11 histone deacetylase 11 -2.0195
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.01947
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa -2.01872
HMHB1 histocompatibility (minor) HB-1 -2.0139
GNA14 guanine nucleotide binding protein (G protein), alpha 14 -2.00375