CRCGN008_HEPG2_24H:A08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,6-dinitrotoluene 19.7 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

102 genes differentially expressed following the CRCGN008_HEPG2_24H:A08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.66765
CCL2 chemokine (C-C motif) ligand 2 5.5503
PPARG peroxisome proliferator-activated receptor gamma 5.1502
MYLK myosin light chain kinase 5.146
CHMP6 charged multivesicular body protein 6 4.95355
AMDHD2 amidohydrolase domain containing 2 4.7779
RPP38 ribonuclease P/MRP 38kDa subunit 4.7351
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.66275
PRR15L proline rich 15-like 3.9149
CHN1 chimerin 1 3.74505
TIAM1 T-cell lymphoma invasion and metastasis 1 3.70347
ARL4C ADP-ribosylation factor-like 4C 3.4166
CDC45 cell division cycle 45 3.3973
RRAGA Ras-related GTP binding A 3.37225
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.08133
DENND2D DENN/MADD domain containing 2D 3.05105
JADE2 jade family PHD finger 2 2.9878
SCRN1 secernin 1 2.74075
SFTPB surfactant protein B 2.73413
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.68713
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.58507
GRWD1 glutamate-rich WD repeat containing 1 2.50165
INPPL1 inositol polyphosphate phosphatase-like 1 2.49715
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.4713
CYCS cytochrome c, somatic 2.35115
PLSCR1 phospholipid scramblase 1 2.23892
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.18658
RNF123 ring finger protein 123 2.18425
GSTZ1 glutathione S-transferase zeta 1 2.17995
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.15455
POU2AF1 POU class 2 associating factor 1 2.09235
MSH2 mutS homolog 2 2.06775
NMU neuromedin U 2.04555
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 2.035
TRIM37 tripartite motif containing 37 2.0075
TSLIG3A tRNA splicing ligase complex subunit 3A 2.00145

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
ZNF586 zinc finger protein 586 -8.8183
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.3124
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.33725
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -5.20438
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.12385
GDF15 growth differentiation factor 15 -5.0
USP6NL USP6 N-terminal like -4.97395
CCNB2 cyclin B2 -4.7944
TRIB3 tribbles pseudokinase 3 -4.5468
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.4555
HLA-DMA major histocompatibility complex, class II, DM alpha -4.125
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -4.0342
FASTKD5 FAST kinase domains 5 -3.35685
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.3135
RNF167 ring finger protein 167 -3.3013
SCAND1 SCAN domain containing 1 -3.18615
ZNF134 zinc finger protein 134 -2.85135
WASHC4 WASH complex subunit 4 -2.84032
OXA1L oxidase (cytochrome c) assembly 1-like -2.6806
ZNF813 zinc finger protein 813 -2.6116
ZNF329 zinc finger protein 329 -2.563
OPRK1 opioid receptor, kappa 1 -2.5151
KLHL25 kelch-like family member 25 -2.5064
LRRC49 leucine rich repeat containing 49 -2.4897
LARP6 La ribonucleoprotein domain family, member 6 -2.46995
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.42085
HSPA6 heat shock 70kDa protein 6 (HSP70B') -2.41932
CBX4 chromobox homolog 4 -2.3943
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -2.3735
FBXL5 F-box and leucine-rich repeat protein 5 -2.34052
LOC128125814 uncharacterized LOC128125814 -2.3226
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -2.31475
CCNH cyclin H -2.30715
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 -2.2924
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.2915
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -2.28495
PNPLA4 patatin-like phospholipase domain containing 4 -2.27992
BAG4 BCL2-associated athanogene 4 -2.27095
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.2313
RXRG retinoid X receptor, gamma -2.2204
ZIM3 zinc finger, imprinted 3 -2.206
ZNF587B zinc finger protein 587B -2.2004
CSTA cystatin A (stefin A) -2.18055
FZD10 frizzled class receptor 10 -2.17685
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 -2.17567
EGFL8 EGF-like-domain, multiple 8 -2.15628
HOXB13 homeobox B13 -2.1394
COG7 component of oligomeric golgi complex 7 -2.1392
BNC1 basonuclin 1 -2.1372
PPP1R17 protein phosphatase 1, regulatory subunit 17 -2.1195
IER3 immediate early response 3 -2.0932
RFPL2 ret finger protein-like 2 -2.089
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -2.08503
ZNF606 zinc finger protein 606 -2.0835
TRIM68 tripartite motif containing 68 -2.0708
PHAF1 phagosome assembly factor 1 -2.07045
HOOK3 hook microtubule-tethering protein 3 -2.05175
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 -2.0472
TTC23 tetratricopeptide repeat domain 23 -2.03765
SELL selectin L -2.0376
ZNF211 zinc finger protein 211 -2.0342
FN3K fructosamine 3 kinase -2.02885
EPHA1 EPH receptor A1 -2.022
ZNF304 zinc finger protein 304 -2.0084
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 -2.00105