CRCGN008_HEPG2_24H:A09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,6-dinitrotoluene 9.85 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

153 genes differentially expressed following the CRCGN008_HEPG2_24H:A09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HLA-DMA major histocompatibility complex, class II, DM alpha 5.42695
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.00905
CBR3 carbonyl reductase 3 4.9741
NOTCH1 notch 1 4.91515
UBQLN2 ubiquilin 2 4.73255
GSTZ1 glutathione S-transferase zeta 1 4.63235
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.5302
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.47585
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.97467
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.969
CIAO3 cytosolic iron-sulfur assembly component 3 3.9375
NNT nicotinamide nucleotide transhydrogenase 3.38667
ABHD4 abhydrolase domain containing 4 3.3143
CHN1 chimerin 1 3.12785
ICAM1 intercellular adhesion molecule 1 2.95657
GATA3 GATA binding protein 3 2.95322
SSBP2 single-stranded DNA binding protein 2 2.7041
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.68105
MAP7 microtubule-associated protein 7 2.6016
CCNF cyclin F 2.5159
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.4833
CDCA4 cell division cycle associated 4 2.44375
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.44135
ZNF146 zinc finger protein 146 2.43915
SCRN1 secernin 1 2.42935
SATB1 SATB homeobox 1 2.411
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.3479
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.34105
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.32678
RAB31 RAB31, member RAS oncogene family 2.3267
LOC122526780 uncharacterized LOC122526780 2.30335
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.2425
BLCAP bladder cancer associated protein 2.222
RBM28 RNA binding motif protein 28 2.19955
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.16305
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 2.12825
MSRA methionine sulfoxide reductase A 2.111
DROSHA drosha, ribonuclease type III 2.1018
DHPS deoxyhypusine synthase 2.08692
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.0749
RSU1 Ras suppressor protein 1 2.0596
MLEC malectin 2.0564
CSK c-src tyrosine kinase 2.04995
PYCR1 pyrroline-5-carboxylate reductase 1 2.0259
ECD ecdysoneless homolog (Drosophila) 2.01865

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -8.48685
PEG10 paternally expressed 10 -6.4908
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -6.4429
PCNA proliferating cell nuclear antigen -5.0
ZNF586 zinc finger protein 586 -4.8285
NUP93 nucleoporin 93kDa -4.76545
MAPK13 mitogen-activated protein kinase 13 -4.71835
TLCD3A TLC domain containing 3A -4.5191
FGFR4 fibroblast growth factor receptor 4 -4.33437
TRIB3 tribbles pseudokinase 3 -4.0097
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.86045
FASTKD5 FAST kinase domains 5 -3.8326
GNAS GNAS complex locus -3.75965
DDIT4 DNA-damage-inducible transcript 4 -3.46955
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.36125
FRZB frizzled-related protein -3.34812
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.29925
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.17815
MPZL1 myelin protein zero-like 1 -3.15595
RPGRIP1L RPGRIP1-like -3.02305
ATF5 activating transcription factor 5 -2.71168
DCAF6 DDB1 and CUL4 associated factor 6 -2.7019
DCC DCC netrin 1 receptor -2.6024
ACAA1 acetyl-CoA acyltransferase 1 -2.58985
SMIM29 small integral membrane protein 29 -2.5714
EAPP E2F-associated phosphoprotein -2.56155
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.55567
CDC25B cell division cycle 25B -2.5484
TMEM19 transmembrane protein 19 -2.54685
SERTAD3 SERTA domain containing 3 -2.52
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.5139
ZNF154 zinc finger protein 154 -2.50765
FGF3 fibroblast growth factor 3 -2.5012
PCDHA9 protocadherin alpha 9 -2.49485
CRLF2 cytokine receptor-like factor 2 -2.48255
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -2.46665
GSG1 germ cell associated 1 -2.43615
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -2.43475
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.4187
ZNF362 zinc finger protein 362 -2.35705
ZNF10 zinc finger protein 10 -2.35165
ZNF343 zinc finger protein 343 -2.3455
CGRRF1 cell growth regulator with ring finger domain 1 -2.334
ZNF671 zinc finger protein 671 -2.3321
PRND prion protein 2 (dublet) -2.31845
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.3169
ZNF548 zinc finger protein 548 -2.3129
NRDE2 NRDE-2, necessary for RNA interference, domain containing -2.3007
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.2978
IFT70A intraflagellar transport 70A -2.2854
PPT2 palmitoyl-protein thioesterase 2 -2.26965
KIF13A kinesin family member 13A -2.2623
SFT2D2 SFT2 domain containing 2 -2.2517
PCDHB8 protocadherin beta 8 -2.25165
GTPBP8 GTP-binding protein 8 (putative) -2.25045
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.241
ZNF682 zinc finger protein 682 -2.22315
ADAMTSL2 ADAMTS-like 2 -2.22285
CNTN5 contactin 5 -2.21855
CD24 CD24 molecule -2.20436
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides -2.187
ZHX2 zinc fingers and homeoboxes 2 -2.182
ZNF667 zinc finger protein 667 -2.173
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase -2.16845
ZDHHC13 zinc finger, DHHC-type containing 13 -2.16285
ZNF493 zinc finger protein 493 -2.1604
EVX1 even-skipped homeobox 1 -2.15665
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 -2.15205
PGK2 phosphoglycerate kinase 2 -2.1514
RAI14 retinoic acid induced 14 -2.14935
ZNF135 zinc finger protein 135 -2.1474
TCP11 t-complex 11, testis-specific -2.14615
DNAH2 dynein, axonemal, heavy chain 2 -2.13745
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -2.13745
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 -2.135
PLA2G2E phospholipase A2, group IIE -2.13165
GUCY2F guanylate cyclase 2F, retinal -2.1293
MTNR1B melatonin receptor 1B -2.12555
DIO3 deiodinase, iodothyronine, type III -2.1232
VWA7 von Willebrand factor A domain containing 7 -2.1228
STAT4 signal transducer and activator of transcription 4 -2.11515
ZNF132 zinc finger protein 132 -2.10595
KCTD15 potassium channel tetramerization domain containing 15 -2.1033
ZNF814 zinc finger protein 814 -2.097
GAGE1 G antigen 1 -2.09695
SOX12 SRY (sex determining region Y)-box 12 -2.08765
ZNF711 zinc finger protein 711 -2.08355
OR2B6 olfactory receptor, family 2, subfamily B, member 6 -2.06215
PLIN2 perilipin 2 -2.0593
CCDC102B coiled-coil domain containing 102B -2.05225
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.0522
NR1H4 nuclear receptor subfamily 1, group H, member 4 -2.04905
SPTA1 spectrin, alpha, erythrocytic 1 -2.03745
CRYGD crystallin, gamma D -2.03105
CCR6 chemokine (C-C motif) receptor 6 -2.02915
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -2.0275
KDM4D lysine (K)-specific demethylase 4D -2.02155
TK2 thymidine kinase 2, mitochondrial -2.02073
FKBP6 FK506 binding protein 6, 36kDa -2.01965
MT1F metallothionein 1F -2.01785
COQ8B coenzyme Q8B -2.017
SLC35F5 solute carrier family 35, member F5 -2.01535
GJA5 gap junction protein, alpha 5, 40kDa -2.01335
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.01275
TM9SF3 transmembrane 9 superfamily member 3 -2.00515
DSTYK dual serine/threonine and tyrosine protein kinase -2.00498
DOC2B double C2-like domains, beta -2.00375
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.0015