CRCGN008_HEPG2_24H:A10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,6-dinitrotoluene 4.93 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

206 genes differentially expressed following the CRCGN008_HEPG2_24H:A10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 5.6903
MELK maternal embryonic leucine zipper kinase 5.26495
STIMATE STIM activating enhancer 5.0118
BACE2 beta-site APP-cleaving enzyme 2 4.9191
ADRB2 adrenoceptor beta 2, surface 4.9142
E2F2 E2F transcription factor 2 4.8812
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.5903
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.50535
ARL4C ADP-ribosylation factor-like 4C 4.39283
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.11755
CCNF cyclin F 3.89272
CCL2 chemokine (C-C motif) ligand 2 3.8862
SNAP25 synaptosomal-associated protein, 25kDa 3.80552
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.75113
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.67585
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.6683
CHN1 chimerin 1 3.6641
MUC1 mucin 1, cell surface associated 3.63912
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.5632
RBL1 retinoblastoma-like 1 3.5123
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.49325
SOX2 SRY (sex determining region Y)-box 2 3.413
HEBP1 heme binding protein 1 3.33165
PLSCR3 phospholipid scramblase 3 3.22133
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 3.18405
CYCS cytochrome c, somatic 3.1367
NENF neudesin neurotrophic factor 3.0222
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.9745
USB1 U6 snRNA biogenesis 1 2.8794
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.74547
ISOC1 isochorismatase domain containing 1 2.7427
RAB21 RAB21, member RAS oncogene family 2.7047
C2CD5 C2 calcium-dependent domain containing 5 2.6907
IL19 interleukin 19 2.62645
LAMP5 lysosomal-associated membrane protein family, member 5 2.6239
TIAM1 T-cell lymphoma invasion and metastasis 1 2.61562
FOXL2 forkhead box L2 2.61275
TMEM160 transmembrane protein 160 2.61065
HELLS helicase, lymphoid-specific 2.61045
PMM2 phosphomannomutase 2 2.6037
NOLC1 nucleolar and coiled-body phosphoprotein 1 2.57428
TNIP1 TNFAIP3 interacting protein 1 2.57085
ENTREP1 endosomal transmembrane epsin interactor 1 2.55515
KLC3 kinesin light chain 3 2.54695
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.53755
LSR lipolysis stimulated lipoprotein receptor 2.5333
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.52975
TTPAL tocopherol (alpha) transfer protein-like 2.52055
PRDM11 PR domain containing 11 2.48885
DNA2 DNA replication helicase/nuclease 2 2.4787
IRGQ immunity-related GTPase family, Q 2.46447
FPGS folylpolyglutamate synthase 2.46195
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.4464
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.4378
PARP1 poly (ADP-ribose) polymerase 1 2.4365
SYN1 synapsin I 2.43475
SCYL3 SCY1-like 3 (S. cerevisiae) 2.42592
HAUS6 HAUS augmin-like complex, subunit 6 2.397
MPPED1 metallophosphoesterase domain containing 1 2.39265
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.38305
SLC75A1 solute carrier family 75 member 1 2.37765
CPZ carboxypeptidase Z 2.36865
LCAT lecithin-cholesterol acyltransferase 2.36485
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.35155
GSK3A glycogen synthase kinase 3 alpha 2.34925
CSNK1A1 casein kinase 1, alpha 1 2.34803
GAA glucosidase, alpha; acid 2.34155
ETNPPL ethanolamine-phosphate phospho-lyase 2.33775
WDR62 WD repeat domain 62 2.3052
DIO2 deiodinase, iodothyronine, type II 2.29408
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.28925
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.2794
FKRP fukutin related protein 2.2495
LOC122526780 uncharacterized LOC122526780 2.22185
MMP26 matrix metallopeptidase 26 2.22085
B4GAT1 beta-1,4-glucuronyltransferase 1 2.21145
TMEM50A transmembrane protein 50A 2.1924
COL4A1 collagen, type IV, alpha 1 2.19065
CENPQ centromere protein Q 2.1905
BRCA1 breast cancer 1, early onset 2.1889
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.1736
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.16725
TMEM59L transmembrane protein 59-like 2.16415
SCRIB scribbled planar cell polarity protein 2.16
NOSIP nitric oxide synthase interacting protein 2.15345
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.1506
ARHGAP11A Rho GTPase activating protein 11A 2.149
PLK1 polo-like kinase 1 2.1414
EPHA3 EPH receptor A3 2.14077
SEC31B SEC31 homolog B (S. cerevisiae) 2.13615
SKA1 spindle and kinetochore associated complex subunit 1 2.13395
OSBPL9 oxysterol binding protein-like 9 2.1256
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 2.1236
GTPBP3 GTP binding protein 3 (mitochondrial) 2.12295
POLR1G RNA polymerase I subunit G 2.1224
NR2F6 nuclear receptor subfamily 2, group F, member 6 2.11955
WNT4 wingless-type MMTV integration site family, member 4 2.1133
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.09635
CDK2 cyclin-dependent kinase 2 2.09445
MED17 mediator complex subunit 17 2.08685
FXN frataxin 2.0856
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.0828
EVL Enah/Vasp-like 2.0812
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.0811
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 2.07923
GUF1 GUF1 GTPase homolog (S. cerevisiae) 2.0781
ANKRD44 ankyrin repeat domain 44 2.07455
ENC1 ectodermal-neural cortex 1 (with BTB domain) 2.07218
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.07025
BICRA BRD4 interacting chromatin remodeling complex associated protein 2.059
LBR lamin B receptor 2.05525
TAC3 tachykinin 3 2.0353
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 2.0285
MAN2B2 mannosidase, alpha, class 2B, member 2 2.0234
UBE2G2 ubiquitin-conjugating enzyme E2G 2 2.0234
NIP7 NIP7, nucleolar pre-rRNA processing protein 2.0151
NEIL3 nei endonuclease VIII-like 3 (E. coli) 2.0142
SMYD2 SET and MYND domain containing 2 2.0076
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 2.0067
TRIM45 tripartite motif containing 45 2.0006
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.00058

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.30365
TRIB3 tribbles pseudokinase 3 -7.2929
VAT1 vesicle amine transport 1 -5.93485
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.8695
EGF epidermal growth factor -5.37595
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.0078
CDC20 cell division cycle 20 -5.0
LDHD lactate dehydrogenase D -4.7432
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.68075
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -4.10365
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.96305
TRAPPC3 trafficking protein particle complex 3 -3.6673
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.63948
FHL2 four and a half LIM domains 2 -3.4685
PEG10 paternally expressed 10 -3.33588
GNAS GNAS complex locus -3.32217
TRIM13 tripartite motif containing 13 -3.21385
FGFR4 fibroblast growth factor receptor 4 -2.90278
ACAA1 acetyl-CoA acyltransferase 1 -2.81978
DPH2 DPH2 homolog (S. cerevisiae) -2.7388
GPX3 glutathione peroxidase 3 -2.73268
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.69645
KRCC1 lysine-rich coiled-coil 1 -2.64585
NLRP2B NLR family pyrin domain containing 2B -2.6386
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 -2.61745
SNX11 sorting nexin 11 -2.53902
PDE9A phosphodiesterase 9A -2.50045
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -2.4788
CD58 CD58 molecule -2.46567
HOXB13 homeobox B13 -2.46295
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.44277
PSRC1 proline/serine-rich coiled-coil 1 -2.42625
GPN1 GPN-loop GTPase 1 -2.4252
UMOD uromodulin -2.4182
FANCF Fanconi anemia, complementation group F -2.41775
RAI14 retinoic acid induced 14 -2.4157
LMBR1L limb development membrane protein 1-like -2.40585
RIC8A RIC8 guanine nucleotide exchange factor A -2.4048
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.40135
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.37245
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -2.37035
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.36705
NKIRAS2 NFKB inhibitor interacting Ras-like 2 -2.32825
LGMN legumain -2.31565
SLC16A4 solute carrier family 16, member 4 -2.3109
NMI N-myc (and STAT) interactor -2.30605
CCNH cyclin H -2.28755
BEX4 brain expressed, X-linked 4 -2.2737
LOC128125814 uncharacterized LOC128125814 -2.2718
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -2.2606
CLIC4 chloride intracellular channel 4 -2.2546
EPHX2 epoxide hydrolase 2, cytoplasmic -2.252
MCOLN3 mucolipin 3 -2.2281
DENND5A DENN/MADD domain containing 5A -2.2264
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -2.22545
AP1B1 adaptor-related protein complex 1, beta 1 subunit -2.2146
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.21315
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -2.21265
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.20215
TSG101 tumor susceptibility 101 -2.1762
ACP2 acid phosphatase 2, lysosomal -2.16975
NRBP1 nuclear receptor binding protein 1 -2.152
FKBP4 FK506 binding protein 4, 59kDa -2.1501
DDR1 discoidin domain receptor tyrosine kinase 1 -2.14444
ITM2A integral membrane protein 2A -2.14403
STAMBP STAM binding protein -2.1391
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.1203
GADD45A growth arrest and DNA-damage-inducible, alpha -2.1142
RNF111 ring finger protein 111 -2.1127
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 -2.11095
TBC1D16 TBC1 domain family, member 16 -2.10835
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A -2.1053
GIMAP4 GTPase, IMAP family member 4 -2.0927
RALYL RALY RNA binding protein-like -2.08235
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 -2.07355
METTL22 methyltransferase like 22 -2.0711
DENND3 DENN/MADD domain containing 3 -2.06265
GTF2A2 general transcription factor IIA, 2, 12kDa -2.05745
MTG1 mitochondrial ribosome-associated GTPase 1 -2.0563
CDCP1 CUB domain containing protein 1 -2.0545
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -2.05315
PRUNE2 prune homolog 2 (Drosophila) -2.04693
ANXA13 annexin A13 -2.04005
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.0218
KL klotho -2.00005