CRCGN008_HEPG2_24H:A12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,6-dinitrotoluene 1.23 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

102 genes differentially expressed following the CRCGN008_HEPG2_24H:A12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CBR3 carbonyl reductase 3 9.976
ADRB2 adrenoceptor beta 2, surface 5.506
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.25005
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.9633
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.85165
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.7348
CARMIL1 capping protein regulator and myosin 1 linker 1 4.6137
ANO1 anoctamin 1, calcium activated chloride channel 4.35045
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.12168
NOSIP nitric oxide synthase interacting protein 3.9417
CIAO3 cytosolic iron-sulfur assembly component 3 3.7396
CCL2 chemokine (C-C motif) ligand 2 3.70215
KDM5A lysine (K)-specific demethylase 5A 3.54227
SSBP2 single-stranded DNA binding protein 2 3.3822
CHN1 chimerin 1 3.3101
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 3.24055
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 3.0637
HEBP1 heme binding protein 1 2.99585
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.94445
PLSCR1 phospholipid scramblase 1 2.8722
ECD ecdysoneless homolog (Drosophila) 2.77275
SFTPB surfactant protein B 2.70573
MAP7 microtubule-associated protein 7 2.66055
PRR15L proline rich 15-like 2.5722
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.50658
SKIC2 SKI2 subunit of superkiller complex 2.4875
ANO10 anoctamin 10 2.43815
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.43675
BAG3 BCL2-associated athanogene 3 2.4173
CCNA1 cyclin A1 2.41335
JADE2 jade family PHD finger 2 2.3837
ZNF589 zinc finger protein 589 2.3577
LYRM1 LYR motif containing 1 2.3503
SCRN1 secernin 1 2.26685
RPIA ribose 5-phosphate isomerase A 2.2629
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.24465
FUCA1 fucosidase, alpha-L- 1, tissue 2.2145
SCYL3 SCY1-like 3 (S. cerevisiae) 2.20305
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 2.18755
DMAC2 distal membrane arm assembly component 2 2.12882
ACP6 acid phosphatase 6, lysophosphatidic 2.11975
GALE UDP-galactose-4-epimerase 2.11845
GPATCH8 G patch domain containing 8 2.08092
L1TD1 LINE-1 type transposase domain containing 1 2.0409
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2.01685

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -5.4378
CDC20 cell division cycle 20 -5.318
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.22905
RAI14 retinoic acid induced 14 -4.16655
FASTKD5 FAST kinase domains 5 -4.09235
FGFR4 fibroblast growth factor receptor 4 -3.77593
ZMIZ1 zinc finger, MIZ-type containing 1 -3.7381
IFRD2 interferon-related developmental regulator 2 -3.67095
RGS2 regulator of G-protein signaling 2 -3.65685
VDAC1 voltage-dependent anion channel 1 -3.55953
LRRN2 leucine rich repeat neuronal 2 -3.1214
OXA1L oxidase (cytochrome c) assembly 1-like -2.8944
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.8364
ARID5B AT rich interactive domain 5B (MRF1-like) -2.76525
DERA deoxyribose-phosphate aldolase (putative) -2.70035
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -2.595
MUC6 mucin 6, oligomeric mucus/gel-forming -2.58715
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.50845
APEH acylaminoacyl-peptide hydrolase -2.4529
PTPRN protein tyrosine phosphatase, receptor type, N -2.4484
CRABP1 cellular retinoic acid binding protein 1 -2.44635
LALBA lactalbumin, alpha- -2.432
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -2.3914
CLEC2D C-type lectin domain family 2, member D -2.36825
SNAI2 snail family zinc finger 2 -2.3663
PPP1R13B protein phosphatase 1, regulatory subunit 13B -2.3513
TCEAL2 transcription elongation factor A (SII)-like 2 -2.32225
ECEL1 endothelin converting enzyme-like 1 -2.31415
OPRD1 opioid receptor, delta 1 -2.29855
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 -2.2931
VENTX VENT homeobox -2.2763
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.2685
GC group-specific component (vitamin D binding protein) -2.24495
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.23195
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.2202
ESRP2 epithelial splicing regulatory protein 2 -2.17675
PLVAP plasmalemma vesicle associated protein -2.17615
DDIT4 DNA-damage-inducible transcript 4 -2.1577
WT1 Wilms tumor 1 -2.15527
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor -2.14715
FKBP4 FK506 binding protein 4, 59kDa -2.14517
H2BC21 H2B clustered histone 21 -2.13625
TCEAL4 transcription elongation factor A (SII)-like 4 -2.1325
CD226 CD226 molecule -2.12695
MACROH2A2 macroH2A.2 histone -2.1122
LAMP5 lysosomal-associated membrane protein family, member 5 -2.09775
TMEM38B transmembrane protein 38B -2.0828
GPR63 G protein-coupled receptor 63 -2.08
ADM2 adrenomedullin 2 -2.07825
GUCA2B guanylate cyclase activator 2B (uroguanylin) -2.06915
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -2.0361
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -2.0322
GTF2IRD2B GTF2I repeat domain containing 2B -2.0143
GPR15 G protein-coupled receptor 15 -2.01425
HPX hemopexin -2.00598
C8G complement component 8, gamma polypeptide -2.0021
UBA6 ubiquitin-like modifier activating enzyme 6 -2.0007