CRCGN008_HEPG2_24H:A13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cimetidine 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN008_HEPG2_24H:A13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 7.0469
CARMIL1 capping protein regulator and myosin 1 linker 1 5.59455
MOK MOK protein kinase 5.2811
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.21005
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.1693
EPHB2 EPH receptor B2 5.13879
RRAGA Ras-related GTP binding A 5.04705
LYN LYN proto-oncogene, Src family tyrosine kinase 4.89317
RPP38 ribonuclease P/MRP 38kDa subunit 4.83485
E2F2 E2F transcription factor 2 4.75955
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.53515
ADRB2 adrenoceptor beta 2, surface 4.17965
BPHL biphenyl hydrolase-like (serine hydrolase) 3.77735
SHB Src homology 2 domain containing adaptor protein B 3.64793
HLA-DRA major histocompatibility complex, class II, DR alpha 3.3768
SNAP25 synaptosomal-associated protein, 25kDa 3.37643
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.3086
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 3.097
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.0062
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.90595
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.71002
ADAT1 adenosine deaminase, tRNA-specific 1 2.676
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.62545
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 2.5256
NANOS2 nanos homolog 2 (Drosophila) 2.49105
ADAM10 ADAM metallopeptidase domain 10 2.38077
EVL Enah/Vasp-like 2.37195
CYCS cytochrome c, somatic 2.3465
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.28653
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2.2733
CETN2 centrin, EF-hand protein, 2 2.2669
DYNLL1 dynein, light chain, LC8-type 1 2.2288
MMP25 matrix metallopeptidase 25 2.2279
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.199
DEFA6 defensin, alpha 6, Paneth cell-specific 2.1814
FTCD formimidoyltransferase cyclodeaminase 2.17515
H2AB2 H2A.B variant histone 2 2.15315
HKDC1 hexokinase domain containing 1 2.14005
PSIP1 PC4 and SFRS1 interacting protein 1 2.12723
PHAF1 phagosome assembly factor 1 2.11065
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.1004
FSTL4 follistatin-like 4 2.09895
CD40 CD40 molecule, TNF receptor superfamily member 5 2.08811
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.0704
GPX2 glutathione peroxidase 2 2.0569
PLCB4 phospholipase C, beta 4 2.04418
ATG9A autophagy related 9A 2.0314
KIF3C kinesin family member 3C 2.02885
CDHR1 cadherin-related family member 1 2.01715
CDCA4 cell division cycle associated 4 2.0042
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.0008

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.1942
GTPBP8 GTP-binding protein 8 (putative) -5.40045
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.16565
CDC20 cell division cycle 20 -5.0
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.87625
LDHD lactate dehydrogenase D -4.85555
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -4.61935
CD320 CD320 molecule -4.52265
HLA-DMA major histocompatibility complex, class II, DM alpha -3.69955
ZMIZ1 zinc finger, MIZ-type containing 1 -3.37685
RNF167 ring finger protein 167 -2.9631
CCNH cyclin H -2.9295
MTA1 metastasis associated 1 -2.8815
RFC2 replication factor C (activator 1) 2, 40kDa -2.8715
RGS2 regulator of G-protein signaling 2 -2.84555
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 -2.716
MACF1 microtubule-actin crosslinking factor 1 -2.69788
FKBP4 FK506 binding protein 4, 59kDa -2.61643
PEG10 paternally expressed 10 -2.5
DDIT4 DNA-damage-inducible transcript 4 -2.41795
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -2.39152
LETMD1 LETM1 domain containing 1 -2.34935
TPK1 thiamin pyrophosphokinase 1 -2.311
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -2.2876
SPON2 spondin 2, extracellular matrix protein -2.27685
CCNT1 cyclin T1 -2.2661
NRIP1 nuclear receptor interacting protein 1 -2.2433
EED embryonic ectoderm development -2.20825
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -2.12808
NES nestin -2.12295
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.1175
ADSL adenylosuccinate lyase -2.0592
OSBPL1A oxysterol binding protein-like 1A -2.04063
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -2.03772
PLPP6 phospholipid phosphatase 6 -2.02255
ADD3 adducin 3 (gamma) -2.00696
DGKD diacylglycerol kinase, delta 130kDa -2.00275