CRCGN008_HEPG2_24H:A14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cimetidine 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN008_HEPG2_24H:A14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BACE2 beta-site APP-cleaving enzyme 2 10.0
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.69324
CXCL2 chemokine (C-X-C motif) ligand 2 5.42785
UBQLN2 ubiquilin 2 5.0657
TAC4 tachykinin 4 (hemokinin) 5.0
CIAO3 cytosolic iron-sulfur assembly component 3 4.993
MYLK myosin light chain kinase 4.9605
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.6959
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.5164
RPL39L ribosomal protein L39-like 4.4415
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 4.3979
EPHA3 EPH receptor A3 4.32717
GPER1 G protein-coupled estrogen receptor 1 3.91385
HLA-DRA major histocompatibility complex, class II, DR alpha 3.58078
PEX11A peroxisomal biogenesis factor 11 alpha 3.51885
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.42693
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.2748
ABHD6 abhydrolase domain containing 6 3.23387
CYCS cytochrome c, somatic 3.18545
SNAP25 synaptosomal-associated protein, 25kDa 2.94683
MAP7 microtubule-associated protein 7 2.93898
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.93085
CHN1 chimerin 1 2.8541
TIAM1 T-cell lymphoma invasion and metastasis 1 2.65637
SFTPB surfactant protein B 2.63927
HPS4 Hermansky-Pudlak syndrome 4 2.4087
PMM2 phosphomannomutase 2 2.3892
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.3551
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.34295
TMEM131L transmembrane 131 like 2.29305
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.26195
CEMIP2 cell migration inducing hyaluronidase 2 2.23865
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2.2307
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.2033
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.1542
BASP1 brain abundant, membrane attached signal protein 1 2.1475
FSD1 fibronectin type III and SPRY domain containing 1 2.1473
MTERF3 mitochondrial transcription termination factor 3 2.1441
MRPL35 mitochondrial ribosomal protein L35 2.12595
LOC122526780 uncharacterized LOC122526780 2.09535
EIF4A3 eukaryotic translation initiation factor 4A3 2.0788
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 2.0346
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.03347
TSPAN5 tetraspanin 5 2.00235

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.3002
COG4 component of oligomeric golgi complex 4 -5.2384
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -5.09482
CCNB2 cyclin B2 -4.9478
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.92165
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.87455
FASTKD5 FAST kinase domains 5 -4.2842
SCAND1 SCAN domain containing 1 -3.06205
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.83815
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.50335
CLTB clathrin, light chain B -2.3678
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.3477
SMC1A structural maintenance of chromosomes 1A -2.34368
CHEK1 checkpoint kinase 1 -2.33725
KIF17 kinesin family member 17 -2.328
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.2955
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -2.1894
MATN4 matrilin 4 -2.1313
BMP4 bone morphogenetic protein 4 -2.1275
RGS2 regulator of G-protein signaling 2 -2.12535
SLC49A3 solute carrier family 49 member 3 -2.09765
CHIC2 cysteine-rich hydrophobic domain 2 -2.0863
SMIM40 small integral membrane protein 40 -2.06545
RGPD1 RANBP2-like and GRIP domain containing 1 -2.06375
MYO1F myosin IF -2.0385