CRCGN008_HEPG2_24H:A15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cimetidine 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

94 genes differentially expressed following the CRCGN008_HEPG2_24H:A15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 9.6168
CHN1 chimerin 1 7.12215
MYLK myosin light chain kinase 5.34755
UBQLN2 ubiquilin 2 4.86525
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.74475
ARL4C ADP-ribosylation factor-like 4C 4.72833
FZD7 frizzled class receptor 7 4.65115
SSBP2 single-stranded DNA binding protein 2 3.9661
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.9512
LOC122526780 uncharacterized LOC122526780 3.7203
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.11489
KIF5C kinesin family member 5C 3.01233
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.8556
ADAT1 adenosine deaminase, tRNA-specific 1 2.5562
TBP TATA box binding protein 2.40415
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.3684
JADE2 jade family PHD finger 2 2.35865
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 2.3087
VCAM1 vascular cell adhesion molecule 1 2.3075
CHEK2 checkpoint kinase 2 2.2905
MCMBP minichromosome maintenance complex binding protein 2.2281
NUP133 nucleoporin 133kDa 2.14015
ARCN1 archain 1 2.11005
CTSO cathepsin O 2.0972
ZNF226 zinc finger protein 226 2.09515
ARGLU1 arginine and glutamate rich 1 2.0003

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.123
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.25325
CCNB2 cyclin B2 -4.0932
FASTKD5 FAST kinase domains 5 -3.7264
GNAS GNAS complex locus -3.49681
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.44318
OXA1L oxidase (cytochrome c) assembly 1-like -3.1421
CRYGC crystallin, gamma C -2.78875
CCNB1 cyclin B1 -2.76935
FBXL12 F-box and leucine-rich repeat protein 12 -2.76505
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.73392
SOAT2 sterol O-acyltransferase 2 -2.63295
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 -2.6209
NGB neuroglobin -2.60705
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -2.56565
RGS2 regulator of G-protein signaling 2 -2.55905
KLHL1 kelch-like family member 1 -2.5432
SLC45A2 solute carrier family 45, member 2 -2.46907
EXD3 exonuclease 3'-5' domain containing 3 -2.4614
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 -2.46075
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) -2.4151
POLL polymerase (DNA directed), lambda -2.41335
MAD2L1BP MAD2L1 binding protein -2.37595
ARR3 arrestin 3, retinal (X-arrestin) -2.3705
THAP11 THAP domain containing 11 -2.3661
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.36502
SSTR5 somatostatin receptor 5 -2.3617
MATN4 matrilin 4 -2.3514
SDK2 sidekick cell adhesion molecule 2 -2.34745
CDH22 cadherin 22, type 2 -2.33915
ITGB1BP1 integrin beta 1 binding protein 1 -2.3266
HUNK hormonally up-regulated Neu-associated kinase -2.31905
MYO15A myosin XVA -2.315
GHRH growth hormone releasing hormone -2.2358
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -2.22415
FBRS fibrosin -2.1954
RFC2 replication factor C (activator 1) 2, 40kDa -2.19208
CRX cone-rod homeobox -2.18625
CDK7 cyclin-dependent kinase 7 -2.18425
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 -2.18135
OCLN occludin -2.17845
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.1652
HOXA6 homeobox A6 -2.1516
BIRC7 baculoviral IAP repeat containing 7 -2.13995
CEMP1 cementum protein 1 -2.1361
OR2H2 olfactory receptor, family 2, subfamily H, member 2 -2.13485
HYDIN HYDIN, axonemal central pair apparatus protein -2.12945
RBBP9 retinoblastoma binding protein 9 -2.12165
ARHGAP4 Rho GTPase activating protein 4 -2.10395
PRDM16 PR domain containing 16 -2.10155
TWSG1 twisted gastrulation BMP signaling modulator 1 -2.1003
NRIP1 nuclear receptor interacting protein 1 -2.0851
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -2.08335
ASMT acetylserotonin O-methyltransferase -2.07652
LMAN1L lectin, mannose-binding, 1 like -2.0742
FGF23 fibroblast growth factor 23 -2.0649
TRPV4 transient receptor potential cation channel, subfamily V, member 4 -2.05595
PHAF1 phagosome assembly factor 1 -2.0498
FGF17 fibroblast growth factor 17 -2.0476
STYXL1 serine/threonine/tyrosine interacting-like 1 -2.0444
PEG10 paternally expressed 10 -2.03662
PCP4 Purkinje cell protein 4 -2.0313
AMN amnion associated transmembrane protein -2.02625
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -2.01676
GBX2 gastrulation brain homeobox 2 -2.01295
HRH2 histamine receptor H2 -2.00845
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -2.007