CRCGN008_HEPG2_24H:A16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cimetidine 4.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

290 genes differentially expressed following the CRCGN008_HEPG2_24H:A16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 10.0
TERT telomerase reverse transcriptase 10.0
CBR3 carbonyl reductase 3 10.0
ARL4C ADP-ribosylation factor-like 4C 8.58297
PHKA1 phosphorylase kinase, alpha 1 (muscle) 6.8404
TAC4 tachykinin 4 (hemokinin) 6.6579
CDCA4 cell division cycle associated 4 6.2916
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 6.1647
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.991
HEBP1 heme binding protein 1 5.7093
SLC75A1 solute carrier family 75 member 1 5.4368
CCNF cyclin F 5.1444
LOC122526780 uncharacterized LOC122526780 4.4377
WDTC1 WD and tetratricopeptide repeats 1 4.2759
CCL2 chemokine (C-C motif) ligand 2 4.1501
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 3.5913
TRIM13 tripartite motif containing 13 3.5309
STXBP2 syntaxin binding protein 2 3.4949
HMBOX1 homeobox containing 1 3.4879
NPDC1 neural proliferation, differentiation and control, 1 3.4249
EXD3 exonuclease 3'-5' domain containing 3 3.2303
OCA2 oculocutaneous albinism II 3.171
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 3.164
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 3.102
ZBTB35 zinc finger and BTB domain containing 35 3.09225
CORO1A coronin, actin binding protein, 1A 3.0066
HMGB3 high mobility group box 3 2.9326
PIH1D1 PIH1 domain containing 1 2.919
DOLPP1 dolichyldiphosphatase 1 2.8808
FOXH1 forkhead box H1 2.8479
RPUSD2 RNA pseudouridylate synthase domain containing 2 2.8234
KRT5 keratin 5, type II 2.7731
SYP synaptophysin 2.7591
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 2.7385
NECAP2 NECAP endocytosis associated 2 2.7174
KEL Kell blood group, metallo-endopeptidase 2.7161
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 2.69103
LDHB lactate dehydrogenase B 2.6738
COX6C cytochrome c oxidase subunit VIc 2.602
ZNF324B zinc finger protein 324B 2.6015
TOR3A torsin family 3, member A 2.5863
LYPLA2 lysophospholipase II 2.5748
SDCBP syndecan binding protein (syntenin) 2.5497
S1PR2 sphingosine-1-phosphate receptor 2 2.5413
CERS2 ceramide synthase 2 2.5094
PARM1 prostate androgen-regulated mucin-like protein 1 2.5029
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.4964
HOXB3 homeobox B3 2.4838
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.4682
PRPF4 pre-mRNA processing factor 4 2.42875
CPLX3 complexin 3 2.4283
DGKH diacylglycerol kinase, eta 2.4269
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.4176
POPDC3 popeye domain containing 3 2.4163
CD81 CD81 molecule 2.3954
SNCB synuclein, beta 2.3936
TRAPPC14 trafficking protein particle complex subunit 14 2.3875
ZNF544 zinc finger protein 544 2.387
KRT14 keratin 14, type I 2.3869
TSPYL1 TSPY-like 1 2.3789
CS citrate synthase 2.3755
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.3726
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.3714
GSTT4 glutathione S-transferase theta 4 2.3687
PRTN3 proteinase 3 2.3501
ZNF222 zinc finger protein 222 2.3406
COL1A2 collagen, type I, alpha 2 2.3403
DSG3 desmoglein 3 2.3343
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 2.3259
GLRA2 glycine receptor, alpha 2 2.3233
KRT81 keratin 81, type II 2.3217
CLCN1 chloride channel, voltage-sensitive 1 2.314
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.2968
TBCE tubulin folding cofactor E 2.2857
ZSCAN2 zinc finger and SCAN domain containing 2 2.2779
ZBTB39 zinc finger and BTB domain containing 39 2.2723
HRAS Harvey rat sarcoma viral oncogene homolog 2.2577
ARR3 arrestin 3, retinal (X-arrestin) 2.2541
SMIM29 small integral membrane protein 29 2.2466
PLD2 phospholipase D2 2.2409
CRYGC crystallin, gamma C 2.2357
NCAPD3 non-SMC condensin II complex, subunit D3 2.2355
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.2258
AVPR1B arginine vasopressin receptor 1B 2.221
CARS1 cysteinyl-tRNA synthetase 1 2.21865
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.2184
SYNGR2 synaptogyrin 2 2.2068
MBD1 methyl-CpG binding domain protein 1 2.2064
REEP2 receptor accessory protein 2 2.2035
RECQL4 RecQ protein-like 4 2.1984
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.1915
RNF123 ring finger protein 123 2.1909
DMTN dematin actin binding protein 2.188
ANXA2 annexin A2 2.1856
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.1742
OXSR1 oxidative stress responsive 1 2.1691
PSPN persephin 2.1637
CRAT carnitine O-acetyltransferase 2.1613
MTCH2 mitochondrial carrier 2 2.153
PYGO1 pygopus family PHD finger 1 2.1351
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 2.1284
CDH22 cadherin 22, type 2 2.1246
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 2.1228
NKX6-1 NK6 homeobox 1 2.1217
TRIM11 tripartite motif containing 11 2.116
RFTN1 raftlin, lipid raft linker 1 2.1142
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 2.1132
TAAR5 trace amine associated receptor 5 2.1109
KRT3 keratin 3, type II 2.1102
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 2.107
CKAP5 cytoskeleton associated protein 5 2.0981
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.098
CCDC57 coiled-coil domain containing 57 2.0955
TMEM41B transmembrane protein 41B 2.09445
LPAR3 lysophosphatidic acid receptor 3 2.0939
SLC35E2B solute carrier family 35, member E2B 2.0927
LYRM1 LYR motif containing 1 2.0878
RRAGC Ras-related GTP binding C 2.0773
ASB6 ankyrin repeat and SOCS box containing 6 2.0769
R3HDM2 R3H domain containing 2 2.0746
PPME1 protein phosphatase methylesterase 1 2.0744
CBARP CACN subunit beta associated regulatory protein 2.0735
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.0729
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.06245
SEPHS2 selenophosphate synthetase 2 2.0621
POMT1 protein-O-mannosyltransferase 1 2.0528
HUNK hormonally up-regulated Neu-associated kinase 2.0521
TP53TG5 TP53 target 5 2.0507
GJD2 gap junction protein, delta 2, 36kDa 2.0392
LETM1 leucine zipper-EF-hand containing transmembrane protein 1 2.0373
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 2.0264
IPO13 importin 13 2.0257
PPP6R1 protein phosphatase 6, regulatory subunit 1 2.0227
MSN moesin 2.0196
IFT22 intraflagellar transport 22 2.0194
CORT cortistatin 2.0151
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2.0146
FOXP3 forkhead box P3 2.0141
ARMC7 armadillo repeat containing 7 2.0123
PADI1 peptidyl arginine deiminase, type I 2.0119
PARD6A par-6 family cell polarity regulator alpha 2.0114
POLM polymerase (DNA directed), mu 2.0102
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 2.0055
IQCC IQ motif containing C 2.0049
GJA8 gap junction protein, alpha 8, 50kDa 2.0022
TIAM1 T-cell lymphoma invasion and metastasis 1 2.0008

decreased expression

Symbol Name Standardized Value
HAT1 histone acetyltransferase 1 -10.0
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -10.0
PCNA proliferating cell nuclear antigen -10.0
HMG20B high mobility group 20B -8.3151
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.5744
FBXO7 F-box protein 7 -6.1797
RFC2 replication factor C (activator 1) 2, 40kDa -5.78455
ICAM3 intercellular adhesion molecule 3 -5.4144
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -5.2425
NRIP1 nuclear receptor interacting protein 1 -4.5301
CHIC2 cysteine-rich hydrophobic domain 2 -4.1733
FKBP10 FK506 binding protein 10, 65 kDa -3.9569
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.8386
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 -3.5607
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -3.5478
NCF2 neutrophil cytosolic factor 2 -3.4719
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -3.17745
C5AR1 complement component 5a receptor 1 -3.1709
BGLAP bone gamma-carboxyglutamate (gla) protein -3.1547
TLR1 toll-like receptor 1 -3.1063
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -3.0973
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -3.0868
CYRIA CYFIP related Rac1 interactor A -2.98085
GMPPA GDP-mannose pyrophosphorylase A -2.9088
FGR FGR proto-oncogene, Src family tyrosine kinase -2.8773
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 -2.8764
COL5A1 collagen, type V, alpha 1 -2.87113
LYRM4 LYR motif containing 4 -2.8604
ADAM9 ADAM metallopeptidase domain 9 -2.8287
TMEM39A transmembrane protein 39A -2.7941
SESN1 sestrin 1 -2.7642
MGMT O-6-methylguanine-DNA methyltransferase -2.7406
MARCHF1 membrane associated ring-CH-type finger 1 -2.7345
FGGY FGGY carbohydrate kinase domain containing -2.7251
CCR1 chemokine (C-C motif) receptor 1 -2.70785
TBXAS1 thromboxane A synthase 1 (platelet) -2.7074
BRD7 bromodomain containing 7 -2.7
GSTT1 glutathione S-transferase theta 1 -2.6246
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.6005
CLTB clathrin, light chain B -2.59833
GRAMD2B GRAM domain containing 2B -2.5862
SAR1B secretion associated, Ras related GTPase 1B -2.5855
MN1 meningioma (disrupted in balanced translocation) 1 -2.5783
IFI30 interferon, gamma-inducible protein 30 -2.5622
TMEM185B transmembrane protein 185B -2.5289
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -2.5056
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -2.4955
CLMN calmin (calponin-like, transmembrane) -2.48875
ABAT 4-aminobutyrate aminotransferase -2.4618
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.4618
CYBB cytochrome b-245, beta polypeptide -2.45035
GIMAP6 GTPase, IMAP family member 6 -2.4464
GABPA GA binding protein transcription factor, alpha subunit 60kDa -2.4402
FBXW11 F-box and WD repeat domain containing 11 -2.4214
RNF130 ring finger protein 130 -2.4203
NLRP4 NLR family, pyrin domain containing 4 -2.4072
EMC8 ER membrane protein complex subunit 8 -2.4043
RASA2 RAS p21 protein activator 2 -2.3895
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -2.3855
ADAP2 ArfGAP with dual PH domains 2 -2.3837
STX11 syntaxin 11 -2.3705
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.3694
STK16 serine/threonine kinase 16 -2.3487
RHOC ras homolog family member C -2.347
TMEM123 transmembrane protein 123 -2.3435
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 -2.34345
PDE1A phosphodiesterase 1A, calmodulin-dependent -2.3426
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) -2.3297
CBX4 chromobox homolog 4 -2.3288
TNF tumor necrosis factor -2.3255
NRGN neurogranin (protein kinase C substrate, RC3) -2.3237
BCR breakpoint cluster region -2.3158
SKI SKI proto-oncogene -2.3156
PLBD1 phospholipase B domain containing 1 -2.3152
MRPS14 mitochondrial ribosomal protein S14 -2.31165
PER3 period circadian clock 3 -2.3026
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -2.3004
BMP4 bone morphogenetic protein 4 -2.2949
CPEB3 cytoplasmic polyadenylation element binding protein 3 -2.2941
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough -2.29165
ARRB2 arrestin, beta 2 -2.2866
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -2.2843
EPPK1 epiplakin 1 -2.2824
BOLA1 bolA family member 1 -2.2814
SLC12A8 solute carrier family 12, member 8 -2.281
HOOK3 hook microtubule-tethering protein 3 -2.2776
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -2.27338
CMC2 C-x(9)-C motif containing 2 -2.2702
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -2.25915
DCSTAMP dendrocyte expressed seven transmembrane protein -2.2397
MEX3D mex-3 RNA binding family member D -2.2366
FHIT fragile histidine triad -2.2196
SFMBT1 Scm-like with four mbt domains 1 -2.2012
BAX BCL2-associated X protein -2.2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -2.1975
LPL lipoprotein lipase -2.1899
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -2.1774
SDC2 syndecan 2 -2.17647
PRR7 proline rich 7 (synaptic) -2.1762
DCLRE1B DNA cross-link repair 1B -2.173
ATG101 autophagy related 101 -2.1678
ANXA9 annexin A9 -2.1674
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 -2.1655
ZFP30 ZFP30 zinc finger protein -2.1567
HCK HCK proto-oncogene, Src family tyrosine kinase -2.1532
GAS7 growth arrest-specific 7 -2.15284
ZNF280D zinc finger protein 280D -2.1467
MTX1 metaxin 1 -2.1455
MYO1F myosin IF -2.1388
BCHE butyrylcholinesterase -2.1221
YAP1 Yes-associated protein 1 -2.1155
RAP1A RAP1A, member of RAS oncogene family -2.1147
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.109
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -2.0985
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.0964
ZFYVE16 zinc finger, FYVE domain containing 16 -2.096
ZC3H7A zinc finger CCCH-type containing 7A -2.0953
WDR44 WD repeat domain 44 -2.0944
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -2.0927
GPHN gephyrin -2.0873
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 -2.08585
ATAD2B ATPase family, AAA domain containing 2B -2.0844
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.08115
SEPTIN8 septin 8 -2.07585
CAMK1D calcium/calmodulin-dependent protein kinase ID -2.0723
BTK Bruton agammaglobulinemia tyrosine kinase -2.0717
ADGRL1 adhesion G protein-coupled receptor L1 -2.06753
CD93 CD93 molecule -2.06685
EXOC5 exocyst complex component 5 -2.0655
MCM5 minichromosome maintenance complex component 5 -2.063
NEK7 NIMA-related kinase 7 -2.0596
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -2.0575
GPATCH2L G patch domain containing 2-like -2.0541
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -2.0521
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.0502
SPI1 Spi-1 proto-oncogene -2.044
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 -2.04305
KCTD20 potassium channel tetramerization domain containing 20 -2.0414
ELP4 elongator acetyltransferase complex subunit 4 -2.0329
MARCHF3 membrane associated ring-CH-type finger 3 -2.016
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -2.0148
ALOX15 arachidonate 15-lipoxygenase -2.0141
PILRA paired immunoglobin-like type 2 receptor alpha -2.01385
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -2.01125