CRCGN008_HEPG2_24H:A20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethyltoluamide 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN008_HEPG2_24H:A20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPL39L ribosomal protein L39-like 5.4212
BACE2 beta-site APP-cleaving enzyme 2 5.36885
ADGRE5 adhesion G protein-coupled receptor E5 5.3628
CARMIL1 capping protein regulator and myosin 1 linker 1 5.08475
TAC4 tachykinin 4 (hemokinin) 5.0
MCOLN1 mucolipin 1 4.97765
PPARG peroxisome proliferator-activated receptor gamma 4.85555
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.7875
UBQLN2 ubiquilin 2 4.77945
PEX11A peroxisomal biogenesis factor 11 alpha 4.58203
NOSIP nitric oxide synthase interacting protein 4.2751
SLC75A1 solute carrier family 75 member 1 3.6227
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.61973
GPER1 G protein-coupled estrogen receptor 1 3.5913
CHN1 chimerin 1 3.2557
CDPF1 cysteine-rich, DPF motif domain containing 1 3.2478
LPAR2 lysophosphatidic acid receptor 2 3.13678
HLA-DRA major histocompatibility complex, class II, DR alpha 2.9272
JADE2 jade family PHD finger 2 2.79545
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.79125
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.7842
DHDDS dehydrodolichyl diphosphate synthase 2.6215
GYG2 glycogenin 2 2.56712
ACACB acetyl-CoA carboxylase beta 2.36461
PDE3B phosphodiesterase 3B, cGMP-inhibited 2.35287
WASF3 WAS protein family, member 3 2.3376
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 2.3304
ADAT1 adenosine deaminase, tRNA-specific 1 2.2962
EPHA3 EPH receptor A3 2.2249
VWA5A von Willebrand factor A domain containing 5A 2.21965
GSTZ1 glutathione S-transferase zeta 1 2.2
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.18155
USO1 USO1 vesicle transport factor 2.18105
MAP7 microtubule-associated protein 7 2.18007
CD40 CD40 molecule, TNF receptor superfamily member 5 2.13596
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.10192
FAM13A family with sequence similarity 13, member A 2.1004
EVL Enah/Vasp-like 2.10035
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.09865
CENPS-CORT CENPS-CORT readthrough 2.0666
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 2.03295
TRIM13 tripartite motif containing 13 2.02895
POM121C POM121 transmembrane nucleoporin C 2.0121
PLTP phospholipid transfer protein 2.00885
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 2.00475
GOLGA7 golgin A7 2.00405

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.4621
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.5911
GOLT1B golgi transport 1B -5.535
CCNB2 cyclin B2 -4.85115
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.8292
MAPK13 mitogen-activated protein kinase 13 -4.32235
LOC124907782 dual specificity protein phosphatase 22 -4.27655
ZMIZ1 zinc finger, MIZ-type containing 1 -4.16345
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -4.05533
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.052
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.47755
ATOX1 antioxidant 1 copper chaperone -3.2414
SCAND1 SCAN domain containing 1 -3.18355
SLC35F2 solute carrier family 35, member F2 -3.123
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.97078
ZW10 zw10 kinetochore protein -2.9426
DCTN3 dynactin 3 (p22) -2.5799
S100A4 S100 calcium binding protein A4 -2.57895
ACAA1 acetyl-CoA acyltransferase 1 -2.5736
DCTN4 dynactin 4 (p62) -2.42245
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.36137
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.33395
HSPE1 heat shock 10kDa protein 1 -2.26785
RUSC2 RUN and SH3 domain containing 2 -2.18545
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.1822
CCNH cyclin H -2.1726
ZNF428 zinc finger protein 428 -2.147
ALOX12B arachidonate 12-lipoxygenase, 12R type -2.10345
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -2.0933
SNRPG small nuclear ribonucleoprotein polypeptide G -2.0849
EDF1 endothelial differentiation-related factor 1 -2.04015