CRCGN008_HEPG2_24H:A21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethyltoluamide 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN008_HEPG2_24H:A21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRR15L proline rich 15-like 5.28045
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.05175
CHMP6 charged multivesicular body protein 6 4.8786
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.86435
RPL39L ribosomal protein L39-like 4.76155
CBR3 carbonyl reductase 3 4.69685
ARL4C ADP-ribosylation factor-like 4C 4.15812
SSBP2 single-stranded DNA binding protein 2 3.89587
KDM5A lysine (K)-specific demethylase 5A 3.59005
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.54895
EGF epidermal growth factor 3.508
SNX7 sorting nexin 7 2.835
GATA2 GATA binding protein 2 2.8085
ADAT1 adenosine deaminase, tRNA-specific 1 2.80445
NNT nicotinamide nucleotide transhydrogenase 2.7286
TBC1D31 TBC1 domain family, member 31 2.6913
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.39747
LOC122526780 uncharacterized LOC122526780 2.358
CYBRD1 cytochrome b reductase 1 2.3452
BEX4 brain expressed, X-linked 4 2.33355
PLSCR3 phospholipid scramblase 3 2.27148
AXIN1 axin 1 2.15645
CYBC1 cytochrome b-245 chaperone 1 2.1479
CRY1 cryptochrome circadian clock 1 2.1214

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.3651
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.85895
TLCD3A TLC domain containing 3A -4.75505
RFC2 replication factor C (activator 1) 2, 40kDa -4.53827
LYPLA1 lysophospholipase I -4.4133
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.4084
MAPK13 mitogen-activated protein kinase 13 -3.86882
FGFR4 fibroblast growth factor receptor 4 -3.67455
NFIL3 nuclear factor, interleukin 3 regulated -2.958
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.83195
WASHC4 WASH complex subunit 4 -2.52328
ILK integrin-linked kinase -2.4873
DERA deoxyribose-phosphate aldolase (putative) -2.4646
ACAA1 acetyl-CoA acyltransferase 1 -2.42167
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.4148
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 -2.1892
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.1775
PARN poly(A)-specific ribonuclease -2.1384
CCDC7 coiled-coil domain containing 7 -2.10135
MRPL15 mitochondrial ribosomal protein L15 -2.0956
FXYD6-FXYD2 FXYD6-FXYD2 readthrough -2.0606
HNMT histamine N-methyltransferase -2.03435
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.00555
CRYZ crystallin, zeta (quinone reductase) -2.0025