CRCGN008_HEPG2_24H:A23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethyltoluamide 2.47 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN008_HEPG2_24H:A23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.2268
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.7021
C2CD2 C2 calcium-dependent domain containing 2 4.50055
IDE insulin-degrading enzyme 4.19712
ZFP36 ZFP36 ring finger protein 3.9939
CBR3 carbonyl reductase 3 3.9038
NOSIP nitric oxide synthase interacting protein 3.7696
PRKCH protein kinase C, eta 3.57085
SMIM40 small integral membrane protein 40 3.3024
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.9332
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.9143
STIMATE STIM activating enhancer 2.8816
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.76535
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.7495
GPATCH8 G patch domain containing 8 2.71275
TBP TATA box binding protein 2.5601
KLHL9 kelch-like family member 9 2.4703
CREG1 cellular repressor of E1A-stimulated genes 1 2.38665
ELAC2 elaC ribonuclease Z 2 2.2655
WASF3 WAS protein family, member 3 2.2179
TMEM109 transmembrane protein 109 2.12605
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.10315
UNG uracil-DNA glycosylase 2.0796
PSIP1 PC4 and SFRS1 interacting protein 1 2.02983
WDTC1 WD and tetratricopeptide repeats 1 2.00237

decreased expression

Symbol Name Standardized Value
LOC124907782 dual specificity protein phosphatase 22 -5.62975
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.62365
ADI1 acireductone dioxygenase 1 -5.1686
RFC2 replication factor C (activator 1) 2, 40kDa -4.35717
JMJD6 jumonji domain containing 6 -3.97815
CCNB1 cyclin B1 -3.8612
CLIC4 chloride intracellular channel 4 -3.4894
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.3385
CCNH cyclin H -3.31825
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -3.29425
DDIT4 DNA-damage-inducible transcript 4 -3.29155
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.2776
HSPA8 heat shock 70kDa protein 8 -3.15633
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.98052
OXA1L oxidase (cytochrome c) assembly 1-like -2.7152
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.6401
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.6183
NRIP1 nuclear receptor interacting protein 1 -2.5695
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.421
HNMT histamine N-methyltransferase -2.26043
RPS5 ribosomal protein S5 -2.23585
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) -2.11928
SARAF store-operated calcium entry-associated regulatory factor -2.10025
INPP1 inositol polyphosphate-1-phosphatase -2.09945
BZW2 basic leucine zipper and W2 domains 2 -2.0588