CRCGN008_HEPG2_24H:B03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN008_HEPG2_24H:B03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.1877
STIMATE STIM activating enhancer 5.1156
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.895
CBR3 carbonyl reductase 3 4.5953
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.52645
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.3622
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.2041
HLA-DRA major histocompatibility complex, class II, DR alpha 3.89005
IDE insulin-degrading enzyme 3.71147
CDPF1 cysteine-rich, DPF motif domain containing 1 3.38135
EGF epidermal growth factor 3.19955
MAP7 microtubule-associated protein 7 3.1007
RRAGA Ras-related GTP binding A 2.87845
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.75817
GPATCH8 G patch domain containing 8 2.73435
CEMIP2 cell migration inducing hyaluronidase 2 2.5958
CDK19 cyclin-dependent kinase 19 2.56478
SCRN1 secernin 1 2.5575
TMEM248 transmembrane protein 248 2.3754
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.27145
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.22513
CNPY3 canopy FGF signaling regulator 3 2.0736
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 2.01795

decreased expression

Symbol Name Standardized Value
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.8472
PCNA proliferating cell nuclear antigen -4.77245
TLCD3A TLC domain containing 3A -4.4182
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.23945
HSPA8 heat shock 70kDa protein 8 -3.03593
ZW10 zw10 kinetochore protein -2.971
SNX11 sorting nexin 11 -2.8033
USP6NL USP6 N-terminal like -2.7327
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -2.62725
HNMT histamine N-methyltransferase -2.56543
OXA1L oxidase (cytochrome c) assembly 1-like -2.5534
KCNIP1 Kv channel interacting protein 1 -2.4958
ITGB1BP1 integrin beta 1 binding protein 1 -2.39863
RBM34 RNA binding motif protein 34 -2.24272
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.23855
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -2.22438
MARCHF1 membrane associated ring-CH-type finger 1 -2.21895
GRN granulin -2.20595
FASTKD5 FAST kinase domains 5 -2.2005
SNTG1 syntrophin, gamma 1 -2.18085
CLIC2 chloride intracellular channel 2 -2.162
LGALS14 lectin, galactoside-binding, soluble, 14 -2.1441
LTA lymphotoxin alpha -2.11815
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 -2.09235
RNFT2 ring finger protein, transmembrane 2 -2.0792
FEZF2 FEZ family zinc finger 2 -2.067
TTPA tocopherol (alpha) transfer protein -2.03195
FAM50B family with sequence similarity 50, member B -2.02835
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -2.01815
CCL16 chemokine (C-C motif) ligand 16 -2.0166
WDCP WD repeat and coiled coil containing -2.0046
RGSL1 regulator of G-protein signaling like 1 -2.00065