CRCGN008_HEPG2_24H:B05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

86 genes differentially expressed following the CRCGN008_HEPG2_24H:B05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 5.84505
BACE2 beta-site APP-cleaving enzyme 2 5.65675
MYLK myosin light chain kinase 5.5565
PPARG peroxisome proliferator-activated receptor gamma 5.25605
PLS1 plastin 1 5.00955
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.79395
KIFBP kinesin family binding protein 4.70365
HLA-DRA major histocompatibility complex, class II, DR alpha 4.0773
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.0372
ARL4C ADP-ribosylation factor-like 4C 3.78518
TIAM1 T-cell lymphoma invasion and metastasis 1 3.57998
GPER1 G protein-coupled estrogen receptor 1 3.46852
CCNA1 cyclin A1 3.1069
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.8668
WASF3 WAS protein family, member 3 2.8533
ADAT1 adenosine deaminase, tRNA-specific 1 2.77675
PLSCR1 phospholipid scramblase 1 2.6865
MRFAP1L1 Morf4 family associated protein 1-like 1 2.6154
CYCS cytochrome c, somatic 2.40185
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.27988
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.26175
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.17065
KIF3B kinesin family member 3B 2.15825
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 2.13565
MCUR1 mitochondrial calcium uniporter regulator 1 2.10455
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.04745
TM9SF2 transmembrane 9 superfamily member 2 2.0313

decreased expression

Symbol Name Standardized Value
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.25325
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.0525
COG4 component of oligomeric golgi complex 4 -4.9145
LDHD lactate dehydrogenase D -4.8667
CD320 CD320 molecule -4.64465
HLA-DMA major histocompatibility complex, class II, DM alpha -4.61055
MAPK13 mitogen-activated protein kinase 13 -3.84033
RFC2 replication factor C (activator 1) 2, 40kDa -3.7606
CCNB2 cyclin B2 -3.6718
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.3633
ACAA1 acetyl-CoA acyltransferase 1 -3.304
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.19605
EXT1 exostosin glycosyltransferase 1 -3.15667
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.95
OXA1L oxidase (cytochrome c) assembly 1-like -2.8776
WASHC4 WASH complex subunit 4 -2.7722
MYO19 myosin XIX -2.5666
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) -2.56625
HEYL hes-related family bHLH transcription factor with YRPW motif-like -2.54865
ST7L suppression of tumorigenicity 7 like -2.51575
PEG10 paternally expressed 10 -2.5
PLA2G1B phospholipase A2, group IB (pancreas) -2.4556
REEP5 receptor accessory protein 5 -2.41725
PRDM14 PR domain containing 14 -2.33305
CAB39L calcium binding protein 39-like -2.32005
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -2.3053
ATOH1 atonal homolog 1 (Drosophila) -2.304
RPS9 ribosomal protein S9 -2.29588
ADAM7 ADAM metallopeptidase domain 7 -2.28375
GJB5 gap junction protein, beta 5, 31.1kDa -2.27555
RPL10L ribosomal protein L10-like -2.27225
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 -2.23885
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 -2.23265
TEX11 testis expressed 11 -2.20775
BMP4 bone morphogenetic protein 4 -2.20545
MCOLN3 mucolipin 3 -2.2028
CRISP1 cysteine-rich secretory protein 1 -2.1564
TACR3 tachykinin receptor 3 -2.14815
NACA2 nascent polypeptide-associated complex alpha subunit 2 -2.1409
ZNF324B zinc finger protein 324B -2.13905
S1PR4 sphingosine-1-phosphate receptor 4 -2.13845
NRBP1 nuclear receptor binding protein 1 -2.1379
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.1367
CD79B CD79b molecule, immunoglobulin-associated beta -2.13055
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.1279
TOM1L2 target of myb1-like 2 (chicken) -2.1259
KLF8 Kruppel-like factor 8 -2.1229
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 -2.1167
PSORS1C1 psoriasis susceptibility 1 candidate 1 -2.1078
AMHR2 anti-Mullerian hormone receptor, type II -2.1052
IFRD1 interferon-related developmental regulator 1 -2.0952
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 -2.0796
CTRC chymotrypsin C (caldecrin) -2.0634
RXFP3 relaxin/insulin-like family peptide receptor 3 -2.0514
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) -2.03915
FOXN1 forkhead box N1 -2.02395
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.0227
PDE11A phosphodiesterase 11A -2.0219
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -2.0173