CRCGN008_HEPG2_24H:B06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

101 genes differentially expressed following the CRCGN008_HEPG2_24H:B06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.7428
STK10 serine/threonine kinase 10 5.0676
PLS1 plastin 1 4.76775
GSTZ1 glutathione S-transferase zeta 1 4.54145
PPARG peroxisome proliferator-activated receptor gamma 4.34295
SSBP2 single-stranded DNA binding protein 2 4.10283
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.97185
PRKCH protein kinase C, eta 3.7534
FPGS folylpolyglutamate synthase 3.7331
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 3.68495
PRR15L proline rich 15-like 3.38195
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.00705
CHN1 chimerin 1 3.00015
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.89935
CHEK2 checkpoint kinase 2 2.85068
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.7991
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.74875
PLSCR3 phospholipid scramblase 3 2.72447
ISG15 ISG15 ubiquitin-like modifier 2.6725
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.60804
KIF20A kinesin family member 20A 2.448
IFI44L interferon-induced protein 44-like 2.3175
TBP TATA box binding protein 2.30605
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.29918
JADE2 jade family PHD finger 2 2.28317
TNIP1 TNFAIP3 interacting protein 1 2.2777
NBPF3 neuroblastoma breakpoint family, member 3 2.27325
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.2634
OASL 2'-5'-oligoadenylate synthetase-like 2.26207
GADD45A growth arrest and DNA-damage-inducible, alpha 2.23005
DSN1 DSN1, MIS12 kinetochore complex component 2.2109
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 2.15975
TOR1A torsin family 1, member A (torsin A) 2.14567
RNF130 ring finger protein 130 2.1282
ADAR adenosine deaminase, RNA-specific 2.1161
SCRN1 secernin 1 2.0809
ESYT1 extended synaptotagmin-like protein 1 2.07235
USP18 ubiquitin specific peptidase 18 2.0722
RSRC2 arginine/serine-rich coiled-coil 2 2.0548
KLF2 Kruppel-like factor 2 2.0498
USP11 ubiquitin specific peptidase 11 2.0387
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 2.0158

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
PCNA proliferating cell nuclear antigen -10.0
CCNB2 cyclin B2 -8.6803
HAT1 histone acetyltransferase 1 -5.3851
PECR peroxisomal trans-2-enoyl-CoA reductase -5.3643
CDC20 cell division cycle 20 -4.6933
ZNF586 zinc finger protein 586 -4.67595
TRIB3 tribbles pseudokinase 3 -4.66275
NGRN neugrin, neurite outgrowth associated -4.57735
SLC35F2 solute carrier family 35, member F2 -4.4986
CD320 CD320 molecule -4.2039
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.13705
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -4.07765
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.85595
FASTKD5 FAST kinase domains 5 -3.8499
TCTN1 tectonic family member 1 -3.54255
CCNB1 cyclin B1 -3.49735
CENPB centromere protein B, 80kDa -3.0974
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 -3.0179
ACAA1 acetyl-CoA acyltransferase 1 -2.93923
DSTN destrin (actin depolymerizing factor) -2.674
SNX11 sorting nexin 11 -2.67357
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.6555
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.36687
SRGN serglycin -2.3554
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -2.3309
BCL2A1 BCL2-related protein A1 -2.31635
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.29345
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -2.2846
MAVS mitochondrial antiviral signaling protein -2.27575
TASP1 taspase, threonine aspartase, 1 -2.23525
OLA1 Obg-like ATPase 1 -2.225
COQ8B coenzyme Q8B -2.22105
OXA1L oxidase (cytochrome c) assembly 1-like -2.215
NSFL1C NSFL1 (p97) cofactor (p47) -2.20753
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) -2.19885
LRRC36 leucine rich repeat containing 36 -2.19075
TGM3 transglutaminase 3 -2.1832
CCP110 centriolar coiled coil protein 110kDa -2.179
TRMT61B tRNA methyltransferase 61B -2.17515
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.16625
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -2.1532
CCR9 chemokine (C-C motif) receptor 9 -2.1313
AQP8 aquaporin 8 -2.1139
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.1123
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.11025
PAX1 paired box 1 -2.10205
CR2 complement component (3d/Epstein Barr virus) receptor 2 -2.08465
PHAF1 phagosome assembly factor 1 -2.07485
RFPL2 ret finger protein-like 2 -2.0601
NEUROD2 neuronal differentiation 2 -2.05755
ZNF423 zinc finger protein 423 -2.04875
PKD1 polycystic kidney disease 1 (autosomal dominant) -2.04263
PLD2 phospholipase D2 -2.02615
CCNH cyclin H -2.0238
IL36R interleukin 36 receptor -2.01985
MKKS McKusick-Kaufman syndrome -2.0198
CLIC5 chloride intracellular channel 5 -2.00765