CRCGN008_HEPG2_24H:B07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,5-trichlorophenoxyacetic acid 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

96 genes differentially expressed following the CRCGN008_HEPG2_24H:B07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 6.02763
RPL39L ribosomal protein L39-like 5.5288
C2CD2 C2 calcium-dependent domain containing 2 5.4927
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.47845
AMDHD2 amidohydrolase domain containing 2 5.27465
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.0
E2F2 E2F transcription factor 2 4.8812
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.5903
PRR15L proline rich 15-like 4.2846
HLA-DMA major histocompatibility complex, class II, DM alpha 4.2777
PPARG peroxisome proliferator-activated receptor gamma 4.23655
SNAP25 synaptosomal-associated protein, 25kDa 3.82212
SSBP2 single-stranded DNA binding protein 2 3.81622
GPER1 G protein-coupled estrogen receptor 1 3.76552
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.69217
VGLL4 vestigial-like family member 4 3.64432
PRKCH protein kinase C, eta 3.63915
TIAM1 T-cell lymphoma invasion and metastasis 1 3.62343
CCNF cyclin F 3.43618
CYCS cytochrome c, somatic 3.10285
LPAR2 lysophosphatidic acid receptor 2 2.75478
MBNL1 muscleblind-like splicing regulator 1 2.67611
EPHA3 EPH receptor A3 2.66498
CCNH cyclin H 2.63835
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.62437
IL17RB interleukin 17 receptor B 2.61245
PLSCR3 phospholipid scramblase 3 2.57025
CDCA4 cell division cycle associated 4 2.4898
NMU neuromedin U 2.4795
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 2.47925
KIF20A kinesin family member 20A 2.46545
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.45805
MAP7 microtubule-associated protein 7 2.45173
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.4186
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 2.33495
HMGB2 high mobility group box 2 2.23965
GMIP GEM interacting protein 2.17885
DENND1C DENN/MADD domain containing 1C 2.1758
TLR4 toll-like receptor 4 2.16
TNIK TRAF2 and NCK interacting kinase 2.12952
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.12778
SCG2 secretogranin II 2.12485
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 2.1228
HPGDS hematopoietic prostaglandin D synthase 2.11845
GRWD1 glutamate-rich WD repeat containing 1 2.1178
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 2.11585
STXBP2 syntaxin binding protein 2 2.1025
TLK2 tousled-like kinase 2 2.085
CLDN15 claudin 15 2.0615
BAMBI BMP and activin membrane-bound inhibitor 2.0418
EVL Enah/Vasp-like 2.0288
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.01725
VTA1 vesicle (multivesicular body) trafficking 1 2.01175
ST14 suppression of tumorigenicity 14 (colon carcinoma) 2.00523

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.29665
ZNF586 zinc finger protein 586 -5.06675
LOC124907782 dual specificity protein phosphatase 22 -4.88355
NRIP1 nuclear receptor interacting protein 1 -4.88083
UBE3C ubiquitin protein ligase E3C -4.54295
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.2955
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.1011
TM9SF3 transmembrane 9 superfamily member 3 -3.8468
CCNB2 cyclin B2 -3.5569
SESN1 sestrin 1 -3.37615
FOS FBJ murine osteosarcoma viral oncogene homolog -3.0848
OXA1L oxidase (cytochrome c) assembly 1-like -3.01645
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog -2.76355
EXT1 exostosin glycosyltransferase 1 -2.75502
TXNDC9 thioredoxin domain containing 9 -2.6369
LGMN legumain -2.63605
COPS7A COP9 signalosome subunit 7A -2.6343
CHIC2 cysteine-rich hydrophobic domain 2 -2.5663
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.5457
ZNF274 zinc finger protein 274 -2.5141
H2BC21 H2B clustered histone 21 -2.51025
KLHL21 kelch-like family member 21 -2.50365
PDIA5 protein disulfide isomerase family A, member 5 -2.4432
ZNF587 zinc finger protein 587 -2.3575
WASHC4 WASH complex subunit 4 -2.32272
GET1 guided entry of tail-anchored proteins factor 1 -2.3006
ZNF787 zinc finger protein 787 -2.29885
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.27343
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -2.24185
EMC6 ER membrane protein complex subunit 6 -2.20865
UBE2M ubiquitin-conjugating enzyme E2M -2.17885
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.1689
KLF10 Kruppel-like factor 10 -2.1591
ATAD2B ATPase family, AAA domain containing 2B -2.1493
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.1443
STXBP1 syntaxin binding protein 1 -2.09235
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q -2.0899
KLHL25 kelch-like family member 25 -2.0658
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -2.04265
NANOS3 nanos homolog 3 (Drosophila) -2.01955
UBXN4 UBX domain protein 4 -2.01715
INSIG2 insulin induced gene 2 -2.0152