| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2,4,5-trichlorophenoxyacetic acid 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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78 genes differentially expressed following the CRCGN008_HEPG2_24H:B08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PPARG | peroxisome proliferator-activated receptor gamma | 9.9062 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 5.37175 |
| ADRB2 | adrenoceptor beta 2, surface | 5.25815 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.1128 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 5.05175 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 5.0365 |
| CHMP6 | charged multivesicular body protein 6 | 5.00995 |
| STIMATE | STIM activating enhancer | 4.9364 |
| UBQLN2 | ubiquilin 2 | 4.84745 |
| EPHA3 | EPH receptor A3 | 4.65622 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.6168 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 4.53225 |
| DENND2D | DENN/MADD domain containing 2D | 4.49775 |
| EPHB2 | EPH receptor B2 | 4.48405 |
| PFKL | phosphofructokinase, liver | 3.9492 |
| CHN1 | chimerin 1 | 3.72975 |
| EGF | epidermal growth factor | 3.67485 |
| TBPL1 | TBP-like 1 | 3.62745 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 3.43147 |
| ABHD6 | abhydrolase domain containing 6 | 3.36532 |
| CCNF | cyclin F | 3.12505 |
| CYCS | cytochrome c, somatic | 3.1064 |
| TBP | TATA box binding protein | 2.9619 |
| JADE2 | jade family PHD finger 2 | 2.88738 |
| NOSIP | nitric oxide synthase interacting protein | 2.7003 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.6865 |
| EVL | Enah/Vasp-like | 2.435 |
| TPRA1 | transmembrane protein, adipocyte asscociated 1 | 2.3506 |
| DNASE1L3 | deoxyribonuclease I-like 3 | 2.29505 |
| STXBP2 | syntaxin binding protein 2 | 2.1673 |
| BCL2L10 | BCL2-like 10 (apoptosis facilitator) | 2.1633 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 2.1484 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.1333 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 2.12305 |
| ZBTB35 | zinc finger and BTB domain containing 35 | 2.114 |
| PGAM4 | phosphoglycerate mutase family member 4 | 2.09395 |
| CUZD1 | CUB and zona pellucida-like domains 1 | 2.08915 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | 2.0775 |
| BCL7C | B-cell CLL/lymphoma 7C | 2.0639 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 2.06005 |
| ZNF428 | zinc finger protein 428 | 2.04175 |
| RNF130 | ring finger protein 130 | 2.0084 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -5.55875 |
| PCNA | proliferating cell nuclear antigen | -5.193 |
| LDHD | lactate dehydrogenase D | -4.97635 |
| CD320 | CD320 molecule | -4.9648 |
| TRIB3 | tribbles pseudokinase 3 | -4.94 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.9253 |
| ENOPH1 | enolase-phosphatase 1 | -4.91905 |
| FASTKD5 | FAST kinase domains 5 | -3.7894 |
| PRPF4 | pre-mRNA processing factor 4 | -3.77275 |
| SPAG4 | sperm associated antigen 4 | -3.219 |
| CCNB1 | cyclin B1 | -3.1498 |
| TRDMT1 | tRNA aspartic acid methyltransferase 1 | -3.0795 |
| RGS2 | regulator of G-protein signaling 2 | -3.01535 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.0075 |
| CCP110 | centriolar coiled coil protein 110kDa | -2.85165 |
| MMP24-AS1-EDEM2 | MMP24-AS1-EDEM2 readthrough | -2.8181 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.7393 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -2.71715 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.66605 |
| TMEM97 | transmembrane protein 97 | -2.58623 |
| COPS4 | COP9 signalosome subunit 4 | -2.5744 |
| NLRP4 | NLR family, pyrin domain containing 4 | -2.5179 |
| TXNDC9 | thioredoxin domain containing 9 | -2.51662 |
| UNC13A | unc-13 homolog A (C. elegans) | -2.37915 |
| RNLS | renalase, FAD-dependent amine oxidase | -2.37485 |
| SYNPO2 | synaptopodin 2 | -2.27805 |
| GNL1 | guanine nucleotide binding protein-like 1 | -2.23075 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.22328 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -2.1672 |
| RBM34 | RNA binding motif protein 34 | -2.16398 |
| SCN1A | sodium channel, voltage gated, type I alpha subunit | -2.15185 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -2.13835 |
| POLH | polymerase (DNA directed), eta | -2.11235 |
| DSTN | destrin (actin depolymerizing factor) | -2.09538 |
| MAP1LC3C | microtubule-associated protein 1 light chain 3 gamma | -2.0841 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -2.0262 |
