| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2,4,5-trichlorophenoxyacetic acid 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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85 genes differentially expressed following the CRCGN008_HEPG2_24H:B11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBQLN2 | ubiquilin 2 | 10.0 |
| CYCS | cytochrome c, somatic | 6.23325 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 5.42405 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 5.04395 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 4.9418 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.8942 |
| WDTC1 | WD and tetratricopeptide repeats 1 | 4.56057 |
| PRR15L | proline rich 15-like | 4.3851 |
| EGF | epidermal growth factor | 4.07505 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 4.00104 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 3.88943 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 3.57825 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 3.55578 |
| MAP7 | microtubule-associated protein 7 | 3.3524 |
| LCN2 | lipocalin 2 | 3.30735 |
| ABHD6 | abhydrolase domain containing 6 | 3.29593 |
| VGLL4 | vestigial-like family member 4 | 3.28822 |
| SFTPB | surfactant protein B | 3.27865 |
| LPAR2 | lysophosphatidic acid receptor 2 | 3.26648 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.18158 |
| CHN1 | chimerin 1 | 2.97735 |
| CDCA4 | cell division cycle associated 4 | 2.8713 |
| TBP | TATA box binding protein | 2.7243 |
| JADE2 | jade family PHD finger 2 | 2.65083 |
| PMM2 | phosphomannomutase 2 | 2.6388 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.63155 |
| TLR4 | toll-like receptor 4 | 2.47345 |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 2.3854 |
| KCTD20 | potassium channel tetramerization domain containing 20 | 2.36795 |
| CEP85 | centrosomal protein 85kDa | 2.34955 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 2.3293 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | 2.3211 |
| PLS3 | plastin 3 | 2.2954 |
| CDK19 | cyclin-dependent kinase 19 | 2.22863 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 2.21882 |
| COXFA4 | cytochrome c oxidase associated subunit FA4 | 2.19915 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.0978 |
| RAB5B | RAB5B, member RAS oncogene family | 2.0566 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 2.0479 |
| CCN4 | cellular communication network factor 4 | 2.04705 |
| TSPYL4 | TSPY-like 4 | 2.04025 |
| COX5B | cytochrome c oxidase subunit Vb | 2.02243 |
| ALG3 | ALG3, alpha-1,3- mannosyltransferase | 2.0035 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -10.0 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -6.3587 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -5.8241 |
| NRIP1 | nuclear receptor interacting protein 1 | -5.49458 |
| DCK | deoxycytidine kinase | -5.3909 |
| ZNF586 | zinc finger protein 586 | -5.2104 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -4.96545 |
| FGFR4 | fibroblast growth factor receptor 4 | -4.80995 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.80965 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.6618 |
| CDC20 | cell division cycle 20 | -4.3123 |
| PEG10 | paternally expressed 10 | -3.96382 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -3.68185 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.66035 |
| CCNB1 | cyclin B1 | -3.4174 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -3.03107 |
| SNX11 | sorting nexin 11 | -2.6453 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.622 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -2.5968 |
| SYNM | synemin, intermediate filament protein | -2.56595 |
| FSHB | follicle stimulating hormone, beta polypeptide | -2.4617 |
| EGFL8 | EGF-like-domain, multiple 8 | -2.44627 |
| A4GALT | alpha 1,4-galactosyltransferase | -2.32875 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | -2.32302 |
| COPZ2 | coatomer protein complex, subunit zeta 2 | -2.3021 |
| HSPA8 | heat shock 70kDa protein 8 | -2.2546 |
| PRRG4 | proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) | -2.2397 |
| CHFR | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | -2.22695 |
| MRM3 | mitochondrial rRNA methyltransferase 3 | -2.22565 |
| DENND4C | DENN/MADD domain containing 4C | -2.14805 |
| NAT10 | N-acetyltransferase 10 (GCN5-related) | -2.14335 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -2.14305 |
| EDNRB | endothelin receptor type B | -2.12705 |
| HLX | H2.0-like homeobox | -2.11545 |
| RLF | rearranged L-myc fusion | -2.105 |
| CDO1 | cysteine dioxygenase type 1 | -2.09575 |
| ZNF197 | zinc finger protein 197 | -2.08395 |
| CSHL1 | chorionic somatomammotropin hormone-like 1 | -2.05344 |
| ADIRF | adipogenesis regulatory factor | -2.04655 |
| ZNF516 | zinc finger protein 516 | -2.04145 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | -2.01425 |
| MSX1 | msh homeobox 1 | -2.00915 |
