CRCGN008_HEPG2_24H:B14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description metronidazole 20.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

177 genes differentially expressed following the CRCGN008_HEPG2_24H:B14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 7.58028
TAC4 tachykinin 4 (hemokinin) 6.45755
CYCS cytochrome c, somatic 6.43845
KLHL21 kelch-like family member 21 5.58555
ADGRE5 adhesion G protein-coupled receptor E5 5.07995
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.978
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.93125
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.76135
UBQLN2 ubiquilin 2 4.6774
LCN2 lipocalin 2 4.66275
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.66275
PPARG peroxisome proliferator-activated receptor gamma 4.63935
CARMIL1 capping protein regulator and myosin 1 linker 1 4.41115
CHMP6 charged multivesicular body protein 6 4.35955
SNAP25 synaptosomal-associated protein, 25kDa 4.2687
EPHA3 EPH receptor A3 4.19322
HLA-DRA major histocompatibility complex, class II, DR alpha 4.1423
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.13455
NOSIP nitric oxide synthase interacting protein 3.9213
CHN1 chimerin 1 3.86305
STXBP2 syntaxin binding protein 2 3.84625
TBPL1 TBP-like 1 3.6481
NMU neuromedin U 3.5638
KIF5C kinesin family member 5C 3.21635
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.0801
GATA3 GATA binding protein 3 3.03442
GPATCH8 G patch domain containing 8 3.02743
ZIC1 Zic family member 1 2.9731
DNM3 dynamin 3 2.8377
PABPC3 poly(A) binding protein, cytoplasmic 3 2.70175
TIAM1 T-cell lymphoma invasion and metastasis 1 2.6964
PLSCR3 phospholipid scramblase 3 2.69228
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.64775
RBM34 RNA binding motif protein 34 2.64308
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 2.62305
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.6214
TFF1 trefoil factor 1 2.61615
SSBP2 single-stranded DNA binding protein 2 2.59965
TMEM35A transmembrane protein 35A 2.5578
STMN2 stathmin 2 2.52927
FAM117A family with sequence similarity 117, member A 2.52775
INA internexin neuronal intermediate filament protein, alpha 2.49685
BAMBI BMP and activin membrane-bound inhibitor 2.4918
CHGB chromogranin B 2.49135
CORO1A coronin, actin binding protein, 1A 2.489
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.45655
LPAR2 lysophosphatidic acid receptor 2 2.44047
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.43555
NUP42 nucleoporin 42 2.4267
RPL36AL ribosomal protein L36a-like 2.42255
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.40855
SKIC2 SKI2 subunit of superkiller complex 2.3717
MACROH2A2 macroH2A.2 histone 2.36245
EVL Enah/Vasp-like 2.3453
PRSS16 protease, serine, 16 (thymus) 2.33945
NAP1L3 nucleosome assembly protein 1-like 3 2.33645
LEFTY1 left-right determination factor 1 2.32385
SLIRP SRA stem-loop interacting RNA binding protein 2.2999
EHD3 EH-domain containing 3 2.2965
AKIRIN1 akirin 1 2.2745
POU2AF1 POU class 2 associating factor 1 2.27235
SLC22A17 solute carrier family 22, member 17 2.24695
MXRA7 matrix-remodelling associated 7 2.23955
JADE2 jade family PHD finger 2 2.23865
DROSHA drosha, ribonuclease type III 2.2264
HOMER1 homer scaffolding protein 1 2.2252
PADI3 peptidyl arginine deiminase, type III 2.22295
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.2071
NEFH neurofilament, heavy polypeptide 2.20552
CLCN2 chloride channel, voltage-sensitive 2 2.1923
FKBP9 FK506 binding protein 9, 63 kDa 2.182
SIRAL2 SIR2 antiphage like 2 2.17965
COCH cochlin 2.17105
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 2.1555
PLAAT1 phospholipase A and acyltransferase 1 2.15053
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 2.14819
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.1077
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.09853
UGT8 UDP glycosyltransferase 8 2.0909
AMBN ameloblastin (enamel matrix protein) 2.0874
SIRT3 sirtuin 3 2.08073
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 2.06833
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.06765
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 2.0673
IGSF1 immunoglobulin superfamily, member 1 2.06575
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 2.0587
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 2.05465
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 2.05437
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 2.05085
TLN1 talin 1 2.0493
RLIM ring finger protein, LIM domain interacting 2.0333
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 2.02855
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 2.02845
SAP30BP SAP30 binding protein 2.0218
LSM12 LSM12 homolog (S. cerevisiae) 2.0197
SLC25A46 solute carrier family 25, member 46 2.0162
FAM168B family with sequence similarity 168, member B 2.01565
AXIN1 axin 1 2.01165
ELP4 elongator acetyltransferase complex subunit 4 2.00385
SLC38A10 solute carrier family 38, member 10 2.00235
UBE2O ubiquitin-conjugating enzyme E2O 2.0016
PTPRS protein tyrosine phosphatase, receptor type, S 2.0004

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -10.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -5.65665
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.39975
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.10895
LOC124907782 dual specificity protein phosphatase 22 -5.0357
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.9963
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.9308
MRPS2 mitochondrial ribosomal protein S2 -4.90015
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.8576
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.778
LDHD lactate dehydrogenase D -4.7549
CCNB2 cyclin B2 -4.7368
NRIP1 nuclear receptor interacting protein 1 -4.67927
ZMIZ1 zinc finger, MIZ-type containing 1 -4.46945
HLA-DMA major histocompatibility complex, class II, DM alpha -4.24775
YME1L1 YME1-like 1 ATPase -4.17018
FGFR4 fibroblast growth factor receptor 4 -4.06787
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.56675
SLC35F2 solute carrier family 35, member F2 -3.4631
OXA1L oxidase (cytochrome c) assembly 1-like -3.37305
SCAND1 SCAN domain containing 1 -3.19505
CLIC4 chloride intracellular channel 4 -3.1715
NHLRC2 NHL repeat containing 2 -3.01195
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.9416
HNMT histamine N-methyltransferase -2.92945
TES testin LIM domain protein -2.90527
KCTD3 potassium channel tetramerization domain containing 3 -2.8235
PACRG PARK2 co-regulated -2.82063
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.7327
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) -2.65033
FBXL12 F-box and leucine-rich repeat protein 12 -2.63995
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) -2.57835
HMOX2 heme oxygenase 2 -2.56915
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.5475
DDTL D-dopachrome tautomerase-like -2.5066
TFEC transcription factor EC -2.5058
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.4621
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.4456
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.44235
CD58 CD58 molecule -2.4292
AADAC arylacetamide deacetylase -2.3932
TP53BP2 tumor protein p53 binding protein 2 -2.34915
ZNF500 zinc finger protein 500 -2.32178
HSPA1B heat shock 70kDa protein 1B -2.31643
CCNH cyclin H -2.30975
ATP10D ATPase, class V, type 10D -2.30115
GET1 guided entry of tail-anchored proteins factor 1 -2.2942
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 -2.28635
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) -2.27925
ANXA3 annexin A3 -2.27695
CYB5A cytochrome b5 type A (microsomal) -2.27572
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.2713
E2F6 E2F transcription factor 6 -2.2513
CD46 CD46 molecule, complement regulatory protein -2.22887
ZNF263 zinc finger protein 263 -2.22565
HMG20B high mobility group 20B -2.2109
WWC3 WWC family member 3 -2.20975
PRPF4 pre-mRNA processing factor 4 -2.20617
KITLG KIT ligand -2.165
MCFD2 multiple coagulation factor deficiency 2 -2.14158
PILRB paired immunoglobin-like type 2 receptor beta -2.13905
ARFRP1 ADP-ribosylation factor related protein 1 -2.12387
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -2.1205
FZD6 frizzled class receptor 6 -2.0803
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -2.0723
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -2.0632
CDC7 cell division cycle 7 -2.06195
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.0603
EIF2D eukaryotic translation initiation factor 2D -2.05585
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -2.04925
RPP40 ribonuclease P/MRP 40kDa subunit -2.04475
MAPK1 mitogen-activated protein kinase 1 -2.0227
LAMP2 lysosomal-associated membrane protein 2 -2.02105
DYNLRB1 dynein, light chain, roadblock-type 1 -2.00842