CRCGN008_HEPG2_24H:B15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description metronidazole 10.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN008_HEPG2_24H:B15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INTS3 integrator complex subunit 3 5.2558
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.1693
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.1486
LOC122526780 uncharacterized LOC122526780 5.129
MYLK myosin light chain kinase 4.9811
EPHB2 EPH receptor B2 4.90405
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.4867
ABHD6 abhydrolase domain containing 6 4.26473
GSTZ1 glutathione S-transferase zeta 1 3.99755
SSBP2 single-stranded DNA binding protein 2 3.85003
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.5715
PRR15L proline rich 15-like 3.56935
GPER1 G protein-coupled estrogen receptor 1 3.2737
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.16195
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.8662
CCNF cyclin F 2.79352
PCDHB11 protocadherin beta 11 2.73724
KIF20A kinesin family member 20A 2.61525
TBP TATA box binding protein 2.4826
CRTAP cartilage associated protein 2.4752
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.41112
SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 2.38212
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.35222
DEFA6 defensin, alpha 6, Paneth cell-specific 2.33315
MAP7 microtubule-associated protein 7 2.3293
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.30555
NCBP3 nuclear cap binding subunit 3 2.25975
DEFA5 defensin, alpha 5, Paneth cell-specific 2.1963
EIF4E eukaryotic translation initiation factor 4E 2.19082
UFSP2 UFM1-specific peptidase 2 2.08795
SCG5 secretogranin V 2.0867
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.0759
SCRN1 secernin 1 2.0636
TLR4 toll-like receptor 4 2.055
MN1 meningioma (disrupted in balanced translocation) 1 2.04125
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.0265
KAT5 K(lysine) acetyltransferase 5 2.02405
MPDU1 mannose-P-dolichol utilization defect 1 2.01475
TSPAN5 tetraspanin 5 2.0112
PCDHB13 protocadherin beta 13 2.00785

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.12155
OXA1L oxidase (cytochrome c) assembly 1-like -6.34985
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -5.90135
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.943
TLCD3A TLC domain containing 3A -4.9092
PLK1 polo-like kinase 1 -4.82835
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.66275
FASTKD5 FAST kinase domains 5 -3.9528
MTA1 metastasis associated 1 -3.05985
CHIC2 cysteine-rich hydrophobic domain 2 -2.6471
CLDN1 claudin 1 -2.4934
DERA deoxyribose-phosphate aldolase (putative) -2.49035
TMED3 transmembrane emp24 protein transport domain containing 3 -2.48105
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.46455
CCNB1 cyclin B1 -2.4504
TMEM160 transmembrane protein 160 -2.2464
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.23515
SFRP5 secreted frizzled-related protein 5 -2.0636
PLCD1 phospholipase C, delta 1 -2.03685