| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | metronidazole 2.56 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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59 genes differentially expressed following the CRCGN008_HEPG2_24H:B17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AMDHD2 | amidohydrolase domain containing 2 | 5.44685 |
| UBQLN2 | ubiquilin 2 | 5.40085 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 5.15965 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 5.0179 |
| CHMP6 | charged multivesicular body protein 6 | 4.93695 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 4.9191 |
| EGF | epidermal growth factor | 4.33015 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 3.96695 |
| WDTC1 | WD and tetratricopeptide repeats 1 | 3.96358 |
| SSBP2 | single-stranded DNA binding protein 2 | 3.86315 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 3.5269 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 3.50225 |
| SOCS2 | suppressor of cytokine signaling 2 | 3.3939 |
| CDCA4 | cell division cycle associated 4 | 3.10405 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.48973 |
| CYCS | cytochrome c, somatic | 2.46825 |
| MAP7 | microtubule-associated protein 7 | 2.42132 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 2.38208 |
| BRD9 | bromodomain containing 9 | 2.28955 |
| MCM3 | minichromosome maintenance complex component 3 | 2.2804 |
| SMAD3 | SMAD family member 3 | 2.26874 |
| COPS7A | COP9 signalosome subunit 7A | 2.24255 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | 2.10247 |
| NMU | neuromedin U | 2.0532 |
| CRTAP | cartilage associated protein | 2.0277 |
| SNX7 | sorting nexin 7 | 2.02225 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 2.00738 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 2.00055 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ACAA1 | acetyl-CoA acyltransferase 1 | -6.39535 |
| VAT1 | vesicle amine transport 1 | -5.45315 |
| NGRN | neugrin, neurite outgrowth associated | -5.40495 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -4.9565 |
| ZNF586 | zinc finger protein 586 | -4.93095 |
| CCNB2 | cyclin B2 | -4.9203 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.8984 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -4.7545 |
| ADI1 | acireductone dioxygenase 1 | -4.50955 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -4.4896 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -4.40055 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -4.31555 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -4.11 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.66165 |
| ZW10 | zw10 kinetochore protein | -3.623 |
| PRPF4 | pre-mRNA processing factor 4 | -3.6112 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.29795 |
| TES | testin LIM domain protein | -3.0615 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.92805 |
| SCAND1 | SCAN domain containing 1 | -2.84065 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -2.80578 |
| MYD88 | myeloid differentiation primary response 88 | -2.7245 |
| SH3YL1 | SH3 and SYLF domain containing 1 | -2.6699 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.46772 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | -2.45615 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -2.441 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.38245 |
| CAVIN3 | caveolae associated protein 3 | -2.3222 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.3111 |
| CDC25B | cell division cycle 25B | -2.1604 |
| CLTB | clathrin, light chain B | -2.02947 |
