CRCGN008_HEPG2_24H:B18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description metronidazole 1.28 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

149 genes differentially expressed following the CRCGN008_HEPG2_24H:B18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 7.69595
E2F2 E2F transcription factor 2 6.26035
LAP3 leucine aminopeptidase 3 5.74335
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 5.72485
OXCT1 3-oxoacid CoA transferase 1 5.62675
CBR3 carbonyl reductase 3 5.37095
MYLK myosin light chain kinase 5.30605
AMDHD2 amidohydrolase domain containing 2 5.2349
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.23275
BTK Bruton agammaglobulinemia tyrosine kinase 5.2085
CAPN1 calpain 1, (mu/I) large subunit 5.12225
NCAPD2 non-SMC condensin I complex, subunit D2 5.0889
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.08855
PLS1 plastin 1 4.9235
EPN2 epsin 2 4.89773
UBQLN2 ubiquilin 2 4.8898
RPP38 ribonuclease P/MRP 38kDa subunit 4.8647
IL1B interleukin 1, beta 4.71133
CIAO3 cytosolic iron-sulfur assembly component 3 4.64525
ARL4C ADP-ribosylation factor-like 4C 4.41212
DNM1 dynamin 1 4.38945
HTRA1 HtrA serine peptidase 1 4.3801
MELK maternal embryonic leucine zipper kinase 4.35855
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 4.09525
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 4.06
NMU neuromedin U 3.9633
SNAP25 synaptosomal-associated protein, 25kDa 3.95615
CHN1 chimerin 1 3.9454
FRS2 fibroblast growth factor receptor substrate 2 3.93645
MUC1 mucin 1, cell surface associated 3.70938
ZBTB35 zinc finger and BTB domain containing 35 3.49347
TBC1D31 TBC1 domain family, member 31 3.4455
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 3.44298
SFTPB surfactant protein B 3.39567
FOXJ3 forkhead box J3 3.29385
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 3.1142
CD79B CD79b molecule, immunoglobulin-associated beta 2.99145
LYN LYN proto-oncogene, Src family tyrosine kinase 2.98413
AKAP8 A kinase (PRKA) anchor protein 8 2.9806
SYK spleen tyrosine kinase 2.95285
GADD45A growth arrest and DNA-damage-inducible, alpha 2.93005
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.91504
PMM2 phosphomannomutase 2 2.8941
SYNE2 spectrin repeat containing, nuclear envelope 2 2.83455
PRKCH protein kinase C, eta 2.77395
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.75205
SESN1 sestrin 1 2.7334
KRT7 keratin 7, type II 2.7261
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.63115
KIF5C kinesin family member 5C 2.59795
MAPK7 mitogen-activated protein kinase 7 2.59645
EMC10 ER membrane protein complex subunit 10 2.49375
DGKG diacylglycerol kinase, gamma 90kDa 2.4933
ADORA3 adenosine A3 receptor 2.44725
OXTR oxytocin receptor 2.4222
AMPH amphiphysin 2.4084
SYN1 synapsin I 2.38975
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.38385
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.38255
NKRF NFKB repressing factor 2.371
SORBS3 sorbin and SH3 domain containing 3 2.3512
OMG oligodendrocyte myelin glycoprotein 2.32725
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 2.3204
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 2.29135
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.28892
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.2583
ZNF589 zinc finger protein 589 2.25652
SYNDIG1 synapse differentiation inducing 1 2.2493
AMH anti-Mullerian hormone 2.236
TAC4 tachykinin 4 (hemokinin) 2.216
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 2.2107
APLNR apelin receptor 2.209
RFC4 replication factor C (activator 1) 4, 37kDa 2.16465
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.1467
DNTT DNA nucleotidylexotransferase 2.14325
NR2C2 nuclear receptor subfamily 2, group C, member 2 2.1429
LPAR3 lysophosphatidic acid receptor 3 2.1425
NOPCHAP1 NOP protein chaperone 1 2.13965
ZNF365 zinc finger protein 365 2.1359
H1-4 H1.4 linker histone, cluster member 2.12375
RBM15 RNA binding motif protein 15 2.12038
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.11387
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.10972
WASHC5 WASH complex subunit 5 2.10825
H1-5 H1.5 linker histone, cluster member 2.1051
ZBED2 zinc finger, BED-type containing 2 2.09405
TUT7 terminal uridylyl transferase 7 2.0892
IL1A interleukin 1, alpha 2.0848
PHF13 PHD finger protein 13 2.0709
ELF4 E74-like factor 4 (ets domain transcription factor) 2.05315
BIK BCL2-interacting killer (apoptosis-inducing) 2.04625
CLDN14 claudin 14 2.0441
CTCF CCCTC-binding factor (zinc finger protein) 2.03385
NSG2 neuronal vesicle trafficking associated 2 2.03355
NLGN1 neuroligin 1 2.0297
CD72 CD72 molecule 2.02625
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.02605
FFAR1 free fatty acid receptor 1 2.02168
CCDC106 coiled-coil domain containing 106 2.0185
CRLF3 cytokine receptor-like factor 3 2.0139
RAB33A RAB33A, member RAS oncogene family 2.0086

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -5.55005
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.4753
THAP11 THAP domain containing 11 -5.3219
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.25325
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.9574
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.88505
LDHD lactate dehydrogenase D -4.87525
ADI1 acireductone dioxygenase 1 -4.7616
NT5DC2 5'-nucleotidase domain containing 2 -4.2489
SLC35F2 solute carrier family 35, member F2 -4.22235
MAPK13 mitogen-activated protein kinase 13 -4.11965
ILK integrin-linked kinase -3.65955
SPAG4 sperm associated antigen 4 -3.6403
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.4534
MAP7 microtubule-associated protein 7 -3.28597
OXA1L oxidase (cytochrome c) assembly 1-like -3.2313
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.0168
ICAM3 intercellular adhesion molecule 3 -2.97005
HLA-DMA major histocompatibility complex, class II, DM alpha -2.90685
ZMIZ1 zinc finger, MIZ-type containing 1 -2.8325
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.80465
ACOX2 acyl-CoA oxidase 2, branched chain -2.52845
CHPT1 choline phosphotransferase 1 -2.4306
GIPC2 GIPC PDZ domain containing family, member 2 -2.4188
RNF167 ring finger protein 167 -2.40525
SNRPC small nuclear ribonucleoprotein polypeptide C -2.40005
ZNF165 zinc finger protein 165 -2.31755
ISL1 ISL LIM homeobox 1 -2.3064
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.29615
PPT2 palmitoyl-protein thioesterase 2 -2.2617
VAT1 vesicle amine transport 1 -2.254
TSKU tsukushi, small leucine rich proteoglycan -2.22315
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -2.2032
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.19895
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.1792
ANXA6 annexin A6 -2.17795
HYAL2 hyaluronoglucosaminidase 2 -2.16
RWDD1 RWD domain containing 1 -2.1518
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -2.12218
SRSF9 serine/arginine-rich splicing factor 9 -2.12003
TM9SF2 transmembrane 9 superfamily member 2 -2.0921
GLOD4 glyoxalase domain containing 4 -2.06355
CLIC4 chloride intracellular channel 4 -2.0472
YAP1 Yes-associated protein 1 -2.04385
AGMAT agmatine ureohydrolase (agmatinase) -2.0361
TCEAL4 transcription elongation factor A (SII)-like 4 -2.03105
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -2.01925
RASIP1 Ras interacting protein 1 -2.01505