CRCGN008_HEPG2_24H:B19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dimethoxyaniline.hcl 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN008_HEPG2_24H:B19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 5.1523
ANO1 anoctamin 1, calcium activated chloride channel 4.9946
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.9878
RPP38 ribonuclease P/MRP 38kDa subunit 4.98355
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.81265
NOTCH1 notch 1 4.7911
PPARG peroxisome proliferator-activated receptor gamma 4.6425
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.44615
ABHD6 abhydrolase domain containing 6 3.80173
LOC122526780 uncharacterized LOC122526780 3.6355
RAB21 RAB21, member RAS oncogene family 3.43835
SIRT3 sirtuin 3 3.19278
MAP7 microtubule-associated protein 7 2.86512
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.7768
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.3699
RIC8A RIC8 guanine nucleotide exchange factor A 2.2238
WDTC1 WD and tetratricopeptide repeats 1 2.22093

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.47515
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0495
ZNF586 zinc finger protein 586 -4.80185
CCNB2 cyclin B2 -4.7794
YME1L1 YME1-like 1 ATPase -4.36608
GNAS GNAS complex locus -3.8166
MTA1 metastasis associated 1 -2.86812
PDZD2 PDZ domain containing 2 -2.86648
OXA1L oxidase (cytochrome c) assembly 1-like -2.69625
TLR4 toll-like receptor 4 -2.5736
FKRP fukutin related protein -2.38085
TBKBP1 TBK1 binding protein 1 -2.3588
ADAMTSL2 ADAMTS-like 2 -2.1914
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 -2.1644
CD58 CD58 molecule -2.14792
ZNF514 zinc finger protein 514 -2.1455
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.14195
GSTT1 glutathione S-transferase theta 1 -2.072
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -2.04225
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -2.00528
MAB21L1 mab-21-like 1 (C. elegans) -2.00155