CRCGN008_HEPG2_24H:B24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dimethoxyaniline.hcl 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN008_HEPG2_24H:B24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.14425
SKIC8 SKI8 subunit of superkiller complex 5.06875
INTS3 integrator complex subunit 3 4.80815
SQOR sulfide quinone oxidoreductase 4.46685
CCNA1 cyclin A1 4.29855
WDTC1 WD and tetratricopeptide repeats 1 3.82098
BPHL biphenyl hydrolase-like (serine hydrolase) 3.80735
CD40 CD40 molecule, TNF receptor superfamily member 5 3.57246
RRAGA Ras-related GTP binding A 3.4306
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.38015
EGF epidermal growth factor 3.37755
NSDHL NAD(P) dependent steroid dehydrogenase-like 3.02052
PMM2 phosphomannomutase 2 2.8939
CDPF1 cysteine-rich, DPF motif domain containing 1 2.8457
RNF167 ring finger protein 167 2.83725
EVL Enah/Vasp-like 2.82045
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.7553
SSBP2 single-stranded DNA binding protein 2 2.69217
MRPL4 mitochondrial ribosomal protein L4 2.6266
CXCL11 chemokine (C-X-C motif) ligand 11 2.55495
STX1A syntaxin 1A (brain) 2.49135
GPATCH8 G patch domain containing 8 2.43322
RASAL1 RAS protein activator like 1 (GAP1 like) 2.352
FGL1 fibrinogen-like 1 2.2585
TOGARAM1 TOG array regulator of axonemal microtubules 1 2.22385
GATA2 GATA binding protein 2 2.2172
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.16673
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.16655
AACS acetoacetyl-CoA synthetase 2.1207
SLURP1 secreted LY6/PLAUR domain containing 1 2.1132
TMEM164 transmembrane protein 164 2.08775
UBA5 ubiquitin-like modifier activating enzyme 5 2.08535
OSBP oxysterol binding protein 2.06498
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.04443
AOPEP aminopeptidase O (putative) 2.0341
ZDHHC13 zinc finger, DHHC-type containing 13 2.0329
UBP1 upstream binding protein 1 (LBP-1a) 2.02865
PYGB phosphorylase, glycogen; brain 2.0263
CCL8 chemokine (C-C motif) ligand 8 2.02135

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.14565
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0
CCNB2 cyclin B2 -4.9478
CD320 CD320 molecule -4.85565
ZMIZ1 zinc finger, MIZ-type containing 1 -4.6556
SLC35F2 solute carrier family 35, member F2 -4.37545
NGRN neugrin, neurite outgrowth associated -4.34045
TWF2 twinfilin actin binding protein 2 -4.32015
RFC2 replication factor C (activator 1) 2, 40kDa -4.28883
GNAS GNAS complex locus -4.11211
HLA-DMA major histocompatibility complex, class II, DM alpha -4.02485
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.7587
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.70845
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.41695
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.14165
OXA1L oxidase (cytochrome c) assembly 1-like -3.12065
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.59435
ODF2 outer dense fiber of sperm tails 2 -2.4689
LOC124900275 extensin-like -2.4603
AP3M2 adaptor-related protein complex 3, mu 2 subunit -2.39555
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -2.30275
XYLT2 xylosyltransferase II -2.288
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.27373
IER3 immediate early response 3 -2.24575
ZW10 zw10 kinetochore protein -2.02005