CRCGN008_HEPG2_24H:C03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzyl-alcohol 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

123 genes differentially expressed following the CRCGN008_HEPG2_24H:C03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 10.0
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 8.54025
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.3822
NOTCH1 notch 1 5.3683
RPP38 ribonuclease P/MRP 38kDa subunit 5.2983
MYLK myosin light chain kinase 5.27825
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.07695
HLA-DMA major histocompatibility complex, class II, DM alpha 4.9701
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.877
NOSIP nitric oxide synthase interacting protein 4.84505
TIMP2 TIMP metallopeptidase inhibitor 2 4.68845
PRR15L proline rich 15-like 4.6718
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.66995
EVL Enah/Vasp-like 4.23115
CDPF1 cysteine-rich, DPF motif domain containing 1 3.86395
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.65385
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.63545
MAP7 microtubule-associated protein 7 3.19303
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 3.13045
H2BC12 H2B clustered histone 12 2.85273
CYB561 cytochrome b561 2.7923
PRSS2 protease, serine, 2 (trypsin 2) 2.7773
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.7735
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.75975
PLSCR3 phospholipid scramblase 3 2.7559
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.70992
DIABLO diablo, IAP-binding mitochondrial protein 2.7046
CHEK2 checkpoint kinase 2 2.6736
WDTC1 WD and tetratricopeptide repeats 1 2.56348
PRDX1 peroxiredoxin 1 2.36515
ZFHX4 zinc finger homeobox 4 2.33155
USP6NL USP6 N-terminal like 2.3005
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 2.27335
MAST2 microtubule associated serine/threonine kinase 2 2.26732
EEIG1 estrogen-induced osteoclastogenesis regulator 1 2.26235
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.26105
ANO1 anoctamin 1, calcium activated chloride channel 2.2349
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 2.22135
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.2146
SRRD SRR1 domain containing 2.2138
FAM222B family with sequence similarity 222, member B 2.1762
APP amyloid beta (A4) precursor protein 2.17483
ZBTB35 zinc finger and BTB domain containing 35 2.17307
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.11438
NINJ2 ninjurin 2 2.11285
KLF7 Kruppel-like factor 7 (ubiquitous) 2.0686
ANXA10 annexin A10 2.0578
CREB1 cAMP responsive element binding protein 1 2.04324
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.02975
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 2.0254
ZNF672 zinc finger protein 672 2.02435
METRN meteorin, glial cell differentiation regulator 2.0211
PROM1 prominin 1 2.01465

decreased expression

Symbol Name Standardized Value
YME1L1 YME1-like 1 ATPase -8.25737
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.92245
TRIB3 tribbles pseudokinase 3 -5.75145
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -5.2731
PLK1 polo-like kinase 1 -5.23465
CD320 CD320 molecule -5.1003
LDHD lactate dehydrogenase D -4.91915
CCNB1 cyclin B1 -4.90055
ISOC1 isochorismatase domain containing 1 -4.7771
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.6857
PCNA proliferating cell nuclear antigen -4.50795
CCNB2 cyclin B2 -4.09565
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.80665
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.37065
MTPAP mitochondrial poly(A) polymerase -3.03905
ZW10 zw10 kinetochore protein -3.0325
ZMIZ1 zinc finger, MIZ-type containing 1 -3.0301
HMG20B high mobility group 20B -2.93523
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.80065
RNFT1-DT RNFT1 divergent transcript -2.78335
WAC WW domain containing adaptor with coiled-coil -2.77555
HSPA8 heat shock 70kDa protein 8 -2.76747
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa -2.65157
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.64858
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.45658
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.4496
EXT1 exostosin glycosyltransferase 1 -2.44615
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 -2.4404
IPP intracisternal A particle-promoted polypeptide -2.4298
NABP2 nucleic acid binding protein 2 -2.4054
KRIT1 KRIT1, ankyrin repeat containing -2.40053
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.382
CNOT3 CCR4-NOT transcription complex, subunit 3 -2.3549
MPHOSPH8 M-phase phosphoprotein 8 -2.3411
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.33253
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) -2.26635
DENND4C DENN/MADD domain containing 4C -2.2638
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.2576
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) -2.25455
GLOD4 glyoxalase domain containing 4 -2.2345
FGF12 fibroblast growth factor 12 -2.2158
RAB38 RAB38, member RAS oncogene family -2.21285
RAI2 retinoic acid induced 2 -2.1904
KIF22 kinesin family member 22 -2.18278
POLM polymerase (DNA directed), mu -2.1617
APIP APAF1 interacting protein -2.1544
CPLX3 complexin 3 -2.13375
COX17 COX17 cytochrome c oxidase copper chaperone -2.1312
PDHX pyruvate dehydrogenase complex, component X -2.112
CRYGC crystallin, gamma C -2.102
UPK3B uroplakin 3B -2.0951
QPCTL glutaminyl-peptide cyclotransferase-like -2.08195
APOE apolipoprotein E -2.07717
LHX1 LIM homeobox 1 -2.07465
CCDC106 coiled-coil domain containing 106 -2.06255
AOC3 amine oxidase, copper containing 3 -2.05565
PTPRS protein tyrosine phosphatase, receptor type, S -2.0508
CADPS2 Ca++-dependent secretion activator 2 -2.0409
RWDD2B RWD domain containing 2B -2.03755
RAI14 retinoic acid induced 14 -2.03545
MOCS1 molybdenum cofactor synthesis 1 -2.03343
PEG10 paternally expressed 10 -2.03192
MYO16 myosin XVI -2.0302
DIXDC1 DIX domain containing 1 -2.03005
HIRIP3 HIRA interacting protein 3 -2.02675
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 -2.02055
MSH3 mutS homolog 3 -2.02033
ABI1 abl-interactor 1 -2.01795
UNC13A unc-13 homolog A (C. elegans) -2.00685
BSG basigin (Ok blood group) -2.0029