CRCGN008_HEPG2_24H:C04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzyl-alcohol 4.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

100 genes differentially expressed following the CRCGN008_HEPG2_24H:C04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
PLSCR1 phospholipid scramblase 1 6.0292
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.2365
PPARG peroxisome proliferator-activated receptor gamma 5.1402
C2CD2 C2 calcium-dependent domain containing 2 5.02175
MYLK myosin light chain kinase 4.9811
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.9582
GSTZ1 glutathione S-transferase zeta 1 4.85245
TBC1D10C TBC1 domain family, member 10C 4.4896
E2F2 E2F transcription factor 2 4.3563
SSBP2 single-stranded DNA binding protein 2 4.2131
HOXA10 homeobox A10 4.17295
FZD7 frizzled class receptor 7 4.1244
VGLL4 vestigial-like family member 4 3.77912
ARL4C ADP-ribosylation factor-like 4C 3.41405
DHDDS dehydrodolichyl diphosphate synthase 3.2227
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.21307
MAP7 microtubule-associated protein 7 3.10475
GPATCH8 G patch domain containing 8 3.00128
RXYLT1 ribitol xylosyltransferase 1 2.8514
ANO1 anoctamin 1, calcium activated chloride channel 2.77045
ZNF589 zinc finger protein 589 2.59165
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.5282
S1PR2 sphingosine-1-phosphate receptor 2 2.52435
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.40465
RAB21 RAB21, member RAS oncogene family 2.39425
FUCA1 fucosidase, alpha-L- 1, tissue 2.39325
CYCS cytochrome c, somatic 2.3909
PLEKHA5 pleckstrin homology domain containing, family A member 5 2.342
SLC46A3 solute carrier family 46, member 3 2.2909
BARX2 BARX homeobox 2 2.2835
EPHA3 EPH receptor A3 2.23858
TACC1 transforming, acidic coiled-coil containing protein 1 2.22312
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.21675
ZHX2 zinc fingers and homeoboxes 2 2.20805
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.20415
DVL3 dishevelled segment polarity protein 3 2.20155
YAP1 Yes-associated protein 1 2.1935
BIRC7 baculoviral IAP repeat containing 7 2.1551
FSD1 fibronectin type III and SPRY domain containing 1 2.1417
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 2.13485
CD59 CD59 molecule, complement regulatory protein 2.12394
SFTPB surfactant protein B 2.10375
TAC4 tachykinin 4 (hemokinin) 2.08385
RPP30 ribonuclease P/MRP 30kDa subunit 2.07025
MDFIC MyoD family inhibitor domain containing 2.06842
CBX7 chromobox homolog 7 2.0656
IRS1 insulin receptor substrate 1 2.04075
XYLT2 xylosyltransferase II 2.0378
CLASRP CLK4-associating serine/arginine rich protein 2.0306
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.02535
DCXR dicarbonyl/L-xylulose reductase 2.021
PTGFR prostaglandin F receptor (FP) 2.0208
MYLIP myosin regulatory light chain interacting protein 2.0169
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.0093

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.33725
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.09935
LDHD lactate dehydrogenase D -5.08075
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.9558
PSRC1 proline/serine-rich coiled-coil 1 -4.8205
GLRX glutaredoxin (thioltransferase) -4.76462
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.7271
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.72195
LAP3 leucine aminopeptidase 3 -4.5927
FGFR4 fibroblast growth factor receptor 4 -4.37257
VDAC1 voltage-dependent anion channel 1 -4.28932
NVL nuclear VCP-like -4.2881
PECR peroxisomal trans-2-enoyl-CoA reductase -4.0314
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.745
FASTKD5 FAST kinase domains 5 -3.35155
GNAS GNAS complex locus -3.30044
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.1793
TWF2 twinfilin actin binding protein 2 -3.112
RGS2 regulator of G-protein signaling 2 -3.0859
TXNDC9 thioredoxin domain containing 9 -2.70928
CHIC2 cysteine-rich hydrophobic domain 2 -2.70185
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.65103
ARID5B AT rich interactive domain 5B (MRF1-like) -2.6427
ACAA1 acetyl-CoA acyltransferase 1 -2.619
SLBP stem-loop binding protein -2.4854
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -2.46965
NRIP1 nuclear receptor interacting protein 1 -2.45495
NCAM2 neural cell adhesion molecule 2 -2.37775
ZSCAN16 zinc finger and SCAN domain containing 16 -2.35945
PMM2 phosphomannomutase 2 -2.3571
ZW10 zw10 kinetochore protein -2.34355
RHBDF2 rhomboid 5 homolog 2 (Drosophila) -2.316
AACS acetoacetyl-CoA synthetase -2.3069
NKRF NFKB repressing factor -2.2527
TSKU tsukushi, small leucine rich proteoglycan -2.236
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -2.2341
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.1879
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -2.17427
FBXO28 F-box protein 28 -2.12622
LMO2 LIM domain only 2 (rhombotin-like 1) -2.0947
NPTX1 neuronal pentraxin I -2.0564
WASF1 WAS protein family, member 1 -2.0523
RPS27L ribosomal protein S27-like -2.0059
SMG8 SMG8 nonsense mediated mRNA decay factor -2.00025
PIEZO1 piezo-type mechanosensitive ion channel component 1 -2.00005