CRCGN008_HEPG2_24H:C05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzyl-alcohol 2.47 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

104 genes differentially expressed following the CRCGN008_HEPG2_24H:C05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SRC SRC proto-oncogene, non-receptor tyrosine kinase 5.82837
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 5.5957
BACE2 beta-site APP-cleaving enzyme 2 4.8692
STIMATE STIM activating enhancer 4.6508
CHMP6 charged multivesicular body protein 6 4.6464
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.62165
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.3431
IDE insulin-degrading enzyme 4.22307
SMAD3 SMAD family member 3 4.11341
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.01732
SNAP25 synaptosomal-associated protein, 25kDa 3.72805
VGLL4 vestigial-like family member 4 3.48038
RPA3 replication protein A3, 14kDa 3.3919
BIRC2 baculoviral IAP repeat containing 2 3.37075
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.2253
SHBG sex hormone-binding globulin 2.98635
CCDC85B coiled-coil domain containing 85B 2.8643
GRM2 glutamate receptor, metabotropic 2 2.82885
DKKL1 dickkopf-like 1 2.6839
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 2.6401
URM1 ubiquitin related modifier 1 2.6233
BPHL biphenyl hydrolase-like (serine hydrolase) 2.61195
PLSCR3 phospholipid scramblase 3 2.5904
CCNP cyclin P 2.5893
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 2.5297
TLR4 toll-like receptor 4 2.51865
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.5094
CBX8 chromobox homolog 8 2.49705
EIF3H eukaryotic translation initiation factor 3, subunit H 2.4856
TBP TATA box binding protein 2.4815
TPSG1 tryptase gamma 1 2.44635
GSK3A glycogen synthase kinase 3 alpha 2.40943
ZNF747 zinc finger protein 747 2.4063
PITX3 paired-like homeodomain 3 2.38715
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.3867
EYA3 EYA transcriptional coactivator and phosphatase 3 2.38485
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.3756
GATA2 GATA binding protein 2 2.3535
KRTAP5-2 keratin associated protein 5-2 2.34095
ACTL7A actin-like 7A 2.33855
CA14 carbonic anhydrase XIV 2.337
GDF5 growth differentiation factor 5 2.3363
DCHS2 dachsous cadherin-related 2 2.3254
FGF6 fibroblast growth factor 6 2.3156
OVOL3 ovo-like zinc finger 3 2.3155
SLC22A14 solute carrier family 22, member 14 2.31205
FNDC8 fibronectin type III domain containing 8 2.29885
GPR21 G protein-coupled receptor 21 2.29
XKR8 XK, Kell blood group complex subunit-related family, member 8 2.2524
FNDC4 fibronectin type III domain containing 4 2.2355
TMPRSS6 transmembrane protease, serine 6 2.21645
ZNRF4 zinc and ring finger 4 2.2021
HDAC11 histone deacetylase 11 2.2
RAX retina and anterior neural fold homeobox 2.1879
CNPY3 canopy FGF signaling regulator 3 2.17065
EDA2R ectodysplasin A2 receptor 2.16955
USP6NL USP6 N-terminal like 2.16605
RORC RAR-related orphan receptor C 2.1618
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 2.149
MIER2 mesoderm induction early response 1, family member 2 2.14663
OR7C2 olfactory receptor, family 7, subfamily C, member 2 2.1433
DRP2 dystrophin related protein 2 2.13825
DGUOK deoxyguanosine kinase 2.12227
SYT2 synaptotagmin II 2.11165
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.11025
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.10025
KAT6B K(lysine) acetyltransferase 6B 2.08432
PARP2 poly (ADP-ribose) polymerase 2 2.08133
PRSS53 protease, serine, 53 2.0813
CUL7 cullin 7 2.07282
IGFBP1 insulin-like growth factor binding protein 1 2.07165
CNGA1 cyclic nucleotide gated channel alpha 1 2.0376
ACKR5 atypical chemokine receptor 5 2.03525
NANOS1 nanos homolog 1 (Drosophila) 2.02405
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 2.01619
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.0153
AVPR1B arginine vasopressin receptor 1B 2.01525
JADE2 jade family PHD finger 2 2.01365
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 2.0054
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.0045

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -6.09705
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.3186
ZNF586 zinc finger protein 586 -5.09785
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.6992
LDHD lactate dehydrogenase D -4.6982
FASTKD5 FAST kinase domains 5 -4.1271
MAPK13 mitogen-activated protein kinase 13 -4.03673
STAT1 signal transducer and activator of transcription 1, 91kDa -2.93368
ANKRD10 ankyrin repeat domain 10 -2.89055
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.81875
NRIP1 nuclear receptor interacting protein 1 -2.64785
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.62662
ZNF134 zinc finger protein 134 -2.5534
ZNF551 zinc finger protein 551 -2.44385
TDRD3 tudor domain containing 3 -2.34157
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.2652
NLRP2 NLR family, pyrin domain containing 2 -2.22835
ZNF180 zinc finger protein 180 -2.21155
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.20352
IRF7 interferon regulatory factor 7 -2.16105
COX7B cytochrome c oxidase subunit VIIb -2.1547
ZNF587B zinc finger protein 587B -2.1264
RBM15 RNA binding motif protein 15 -2.0632
PRCC papillary renal cell carcinoma (translocation-associated) -2.01095