CRCGN008_HEPG2_24H:C07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1,1-trichloroethane, technical grade 39.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

135 genes differentially expressed following the CRCGN008_HEPG2_24H:C07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 5.1748
CHMP6 charged multivesicular body protein 6 5.04775
CCNA1 cyclin A1 4.9527
WDTC1 WD and tetratricopeptide repeats 1 4.89623
E2F2 E2F transcription factor 2 4.8026
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.79255
LCN2 lipocalin 2 4.66275
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 4.10465
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.90932
CCL2 chemokine (C-C motif) ligand 2 3.723
SNAP25 synaptosomal-associated protein, 25kDa 3.625
LOC122526780 uncharacterized LOC122526780 3.595
TIAM1 T-cell lymphoma invasion and metastasis 1 3.41497
HEBP1 heme binding protein 1 3.352
KDM5A lysine (K)-specific demethylase 5A 3.16438
SIRT3 sirtuin 3 3.13768
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.05093
ANO1 anoctamin 1, calcium activated chloride channel 2.8659
SSBP2 single-stranded DNA binding protein 2 2.82885
GPATCH8 G patch domain containing 8 2.74445
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.72785
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.70968
PCBP1 poly(rC) binding protein 1 2.6884
UBE2D3 ubiquitin-conjugating enzyme E2D 3 2.67937
H2BC12 H2B clustered histone 12 2.65013
ARR3 arrestin 3, retinal (X-arrestin) 2.6314
NMU neuromedin U 2.6219
BPHL biphenyl hydrolase-like (serine hydrolase) 2.5825
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.5413
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.5209
PLA2G4B phospholipase A2, group IVB (cytosolic) 2.46875
TUBA4B tubulin, alpha 4b 2.4595
AMBN ameloblastin (enamel matrix protein) 2.4594
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.39675
GJD2 gap junction protein, delta 2, 36kDa 2.39465
ERN2 endoplasmic reticulum to nucleus signaling 2 2.39
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 2.38825
TBP TATA box binding protein 2.37735
MRPL49 mitochondrial ribosomal protein L49 2.3419
NPDC1 neural proliferation, differentiation and control, 1 2.3361
ALPK1 alpha-kinase 1 2.32315
MMP1 matrix metallopeptidase 1 2.321
MORF4L2 mortality factor 4 like 2 2.31665
KRTAP5-2 keratin associated protein 5-2 2.30535
TRMT5 tRNA methyltransferase 5 2.29395
GRPR gastrin-releasing peptide receptor 2.28845
NLRX1 NLR family member X1 2.2458
JADE2 jade family PHD finger 2 2.2458
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.2397
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.2281
FOS FBJ murine osteosarcoma viral oncogene homolog 2.22315
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.22
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 2.21115
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 2.1931
LYRM9 LYR motif containing 9 2.18385
KLF15 Kruppel-like factor 15 2.1728
MPPE1 metallophosphoesterase 1 2.16395
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.16205
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.1554
GDF5 growth differentiation factor 5 2.14165
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 2.13925
ZNF232 zinc finger protein 232 2.13385
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 2.13205
KLHL25 kelch-like family member 25 2.1138
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.0945
EOLA1 endothelium and lymphocyte associated ASCH domain 1 2.09398
CEMIP cell migration inducing protein, hyaluronan binding 2.09145
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 2.09045
BIN3 bridging integrator 3 2.0855
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.0647
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2.06225
IRAK4 interleukin-1 receptor-associated kinase 4 2.06205
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 2.0524
UCMA upper zone of growth plate and cartilage matrix associated 2.05225
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.0468
KRT9 keratin 9, type I 2.0287
CT55 cancer/testis antigen 55 2.02565
DENND1C DENN/MADD domain containing 1C 2.02545
SHB Src homology 2 domain containing adaptor protein B 2.02383
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 2.0217
PROP1 PROP paired-like homeobox 1 2.01925
CDCA4 cell division cycle associated 4 2.019
FTO fat mass and obesity associated 2.01825
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A 2.0159
TSPO translocator protein (18kDa) 2.01405
CD5 CD5 molecule 2.0116
STYXL1 serine/threonine/tyrosine interacting-like 1 2.0113
KLHL29 kelch-like family member 29 2.00985
DLK2 delta-like 2 homolog (Drosophila) 2.0023

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.93175
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -7.13907
UGDH UDP-glucose 6-dehydrogenase -5.5237
C2CD5 C2 calcium-dependent domain containing 5 -5.3098
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.14725
TRIB3 tribbles pseudokinase 3 -5.06985
NT5DC2 5'-nucleotidase domain containing 2 -4.97145
GTPBP8 GTP-binding protein 8 (putative) -4.9611
LDHD lactate dehydrogenase D -4.938
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.67205
CDC20 cell division cycle 20 -4.66275
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.5436
NISCH nischarin -4.35135
HMG20B high mobility group 20B -4.33665
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.8424
GNAS GNAS complex locus -3.53365
GDF15 growth differentiation factor 15 -3.45915
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.4204
RGS2 regulator of G-protein signaling 2 -3.1539
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.01717
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.0072
ZFYVE16 zinc finger, FYVE domain containing 16 -2.8626
MITF microphthalmia-associated transcription factor -2.7928
S100A4 S100 calcium binding protein A4 -2.7151
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.66215
NRIP1 nuclear receptor interacting protein 1 -2.59295
ACAA1 acetyl-CoA acyltransferase 1 -2.57257
PDE9A phosphodiesterase 9A -2.50815
FEM1C fem-1 homolog c (C. elegans) -2.47615
MNX1 motor neuron and pancreas homeobox 1 -2.44695
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.4229
MYO5A myosin VA (heavy chain 12, myoxin) -2.3889
SOBP sine oculis binding protein homolog (Drosophila) -2.36055
NCK2 NCK adaptor protein 2 -2.35995
LAMP3 lysosomal-associated membrane protein 3 -2.29075
CCNB1 cyclin B1 -2.2797
TBC1D22B TBC1 domain family, member 22B -2.2718
ADAM15 ADAM metallopeptidase domain 15 -2.14805
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.1424
AQP8 aquaporin 8 -2.13175
ZNF518A zinc finger protein 518A -2.1135
CCP110 centriolar coiled coil protein 110kDa -2.1095
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) -2.0793
ADAMDEC1 ADAM-like, decysin 1 -2.04725
CD83 CD83 molecule -2.018
NOP53 NOP53 ribosome biogenesis factor -2.00295