CRCGN008_HEPG2_24H:C08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1,1-trichloroethane, technical grade 19.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

273 genes differentially expressed following the CRCGN008_HEPG2_24H:C08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 5.51335
TBPL1 TBP-like 1 5.5078
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 5.4177
SYNE2 spectrin repeat containing, nuclear envelope 2 5.3854
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.27695
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.26355
ADRB2 adrenoceptor beta 2, surface 5.24045
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.0179
CCL2 chemokine (C-C motif) ligand 2 4.9791
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.95635
KLHL21 kelch-like family member 21 4.9546
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.92015
GSTZ1 glutathione S-transferase zeta 1 4.89475
MYLK myosin light chain kinase 4.88805
E2F2 E2F transcription factor 2 4.8812
MAMLD1 mastermind-like domain containing 1 4.8489
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.831
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.82735
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.8105
STAP2 signal transducing adaptor family member 2 4.79845
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.7919
LCN2 lipocalin 2 4.79055
CARMIL1 capping protein regulator and myosin 1 linker 1 4.7155
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.5903
CAPN1 calpain 1, (mu/I) large subunit 4.53835
EVL Enah/Vasp-like 4.4233
BACE2 beta-site APP-cleaving enzyme 2 4.39365
STK10 serine/threonine kinase 10 4.34802
UBQLN2 ubiquilin 2 4.28005
SNAP25 synaptosomal-associated protein, 25kDa 4.2789
EPN2 epsin 2 4.17298
PRKX protein kinase, X-linked 4.05937
HDGFL3 HDGF like 3 4.03603
NLRP4 NLR family, pyrin domain containing 4 4.02255
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.01745
EPHB2 EPH receptor B2 4.00166
LPAR2 lysophosphatidic acid receptor 2 3.96042
GPER1 G protein-coupled estrogen receptor 1 3.93135
CDPF1 cysteine-rich, DPF motif domain containing 1 3.8776
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.80678
AURKA aurora kinase A 3.78905
ARL4C ADP-ribosylation factor-like 4C 3.67002
CCNA1 cyclin A1 3.49685
KIF5C kinesin family member 5C 3.49028
RPA3 replication protein A3, 14kDa 3.38265
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.34855
OXCT1 3-oxoacid CoA transferase 1 3.21705
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.1859
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.15143
STXBP2 syntaxin binding protein 2 3.1371
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.12325
KLK11 kallikrein-related peptidase 11 3.11475
STC1 stanniocalcin 1 3.07875
PRSS23 protease, serine, 23 3.07585
INSIG1 insulin induced gene 1 3.07028
COL16A1 collagen, type XVI, alpha 1 3.0606
PDLIM4 PDZ and LIM domain 4 2.95205
KLHL9 kelch-like family member 9 2.91625
TBC1D31 TBC1 domain family, member 31 2.89355
KLHDC8A kelch domain containing 8A 2.8761
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.8761
CCNF cyclin F 2.85495
MAP7 microtubule-associated protein 7 2.85113
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.84595
ZBTB35 zinc finger and BTB domain containing 35 2.80225
ACHE acetylcholinesterase (Yt blood group) 2.78503
TXNL4B thioredoxin-like 4B 2.771
CDK4 cyclin-dependent kinase 4 2.7631
FGFBP1 fibroblast growth factor binding protein 1 2.7374
PAEP progestagen-associated endometrial protein 2.7345
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.68735
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.67485
SATB1 SATB homeobox 1 2.65965
MUC2 mucin 2, oligomeric mucus/gel-forming 2.65345
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.6347
EFHD2 EF-hand domain family, member D2 2.5962
DENND2D DENN/MADD domain containing 2D 2.5869
ANKRD10 ankyrin repeat domain 10 2.57375
ITFG1 integrin alpha FG-GAP repeat containing 1 2.5624
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.5508
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.53945
AATF apoptosis antagonizing transcription factor 2.5318
C2CD2L C2CD2-like 2.52375
PGRMC1 progesterone receptor membrane component 1 2.52242
COQ8A coenzyme Q8A 2.49715
FBXO31 F-box protein 31 2.49385
SCN1B sodium channel, voltage gated, type I beta subunit 2.48605
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.48375
ZFPM2 zinc finger protein, FOG family member 2 2.4636
CA10 carbonic anhydrase X 2.44735
KEL Kell blood group, metallo-endopeptidase 2.4472
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 2.4447
CENPE centromere protein E, 312kDa 2.44425
MYBPC2 myosin binding protein C, fast type 2.4409
POLM polymerase (DNA directed), mu 2.43625
STXBP1 syntaxin binding protein 1 2.4322
GATA4 GATA binding protein 4 2.4187
LINC02762 long intergenic non-protein coding RNA 2762 2.41565
NPDC1 neural proliferation, differentiation and control, 1 2.40885
MB myoglobin 2.404
CYCS cytochrome c, somatic 2.40355
TBC1D3G TBC1 domain family member 3G 2.39365
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.3825
TLR3 toll-like receptor 3 2.37025
NINL ninein-like 2.36695
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.3668
EPHA3 EPH receptor A3 2.36407
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.35605
RAD50 RAD50 homolog (S. cerevisiae) 2.32662
XYLT2 xylosyltransferase II 2.31925
SHB Src homology 2 domain containing adaptor protein B 2.31818
CKM creatine kinase, muscle 2.30645
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 2.30035
PMM2 phosphomannomutase 2 2.2933
POMP proteasome maturation protein 2.2905
IL1R2 interleukin 1 receptor, type II 2.27395
ULK1 unc-51 like autophagy activating kinase 1 2.2678
NT5M 5',3'-nucleotidase, mitochondrial 2.2629
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 2.2602
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 2.2591
ANK2 ankyrin 2, neuronal 2.25698
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.25665
ZDHHC4 zinc finger, DHHC-type containing 4 2.25655
ZNF185 zinc finger protein 185 (LIM domain) 2.25075
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.2402
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 2.23535
SIRT2 sirtuin 2 2.2333
CAPRIN2 caprin family member 2 2.21775
ZFYVE21 zinc finger, FYVE domain containing 21 2.2176
DRC9 dynein regulatory complex subunit 9 2.1904
PDZRN3 PDZ domain containing ring finger 3 2.1841
CXCL5 chemokine (C-X-C motif) ligand 5 2.1793
SPINK4 serine peptidase inhibitor, Kazal type 4 2.1691
JADE2 jade family PHD finger 2 2.16845
SAP30L SAP30-like 2.16835
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.1666
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.16355
TLR4 toll-like receptor 4 2.15745
SRPK3 SRSF protein kinase 3 2.1538
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.143
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 2.1321
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.1266
ZNF84 zinc finger protein 84 2.1259
INTS15 integrator complex subunit 15 2.11442
CD40 CD40 molecule, TNF receptor superfamily member 5 2.0954
NDP Norrie disease (pseudoglioma) 2.0905
TNIP1 TNFAIP3 interacting protein 1 2.08785
NMU neuromedin U 2.0797
DZIP1 DAZ interacting zinc finger protein 1 2.0736
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.07175
WDR62 WD repeat domain 62 2.0652
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.05905
CRY2 cryptochrome circadian clock 2 2.0579
NUAK2 NUAK family, SNF1-like kinase, 2 2.05395
FOXL2 forkhead box L2 2.05335
F8 coagulation factor VIII, procoagulant component 2.0522
MCF2L MCF.2 cell line derived transforming sequence-like 2.0491
TARP TCR gamma alternate reading frame protein 2.04373
TAOK3 TAO kinase 3 2.03415
UCN urocortin 2.0287
CREB3L1 cAMP responsive element binding protein 3-like 1 2.02702
ZNF862 zinc finger protein 862 2.0204
ATAD3A ATPase family, AAA domain containing 3A 2.0173
EHBP1L1 EH domain binding protein 1-like 1 2.01167

decreased expression

Symbol Name Standardized Value
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.58895
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.5132
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.33385
PCNA proliferating cell nuclear antigen -5.193
ALAS1 5'-aminolevulinate synthase 1 -5.14185
ZW10 zw10 kinetochore protein -5.05925
STAT1 signal transducer and activator of transcription 1, 91kDa -4.97555
DERA deoxyribose-phosphate aldolase (putative) -4.90975
PCCB propionyl CoA carboxylase, beta polypeptide -4.8776
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.6568
THAP11 THAP domain containing 11 -4.5939
ILK integrin-linked kinase -4.1032
TCERG1 transcription elongation regulator 1 -4.0106
FGFR4 fibroblast growth factor receptor 4 -3.85795
GNAS GNAS complex locus -3.75994
DCK deoxycytidine kinase -3.65385
CASP3 caspase 3, apoptosis-related cysteine peptidase -3.63775
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.60612
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -3.57735
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.5382
FOS FBJ murine osteosarcoma viral oncogene homolog -3.43955
OXA1L oxidase (cytochrome c) assembly 1-like -3.42985
ADGRG1 adhesion G protein-coupled receptor G1 -3.42242
FASTKD5 FAST kinase domains 5 -3.38925
CHMP4B charged multivesicular body protein 4B -3.30223
GTPBP8 GTP-binding protein 8 (putative) -3.2949
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -3.2401
UGDH UDP-glucose 6-dehydrogenase -2.98895
GET1 guided entry of tail-anchored proteins factor 1 -2.98805
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.98405
DYNLT3 dynein, light chain, Tctex-type 3 -2.8891
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.8694
IER3 immediate early response 3 -2.78315
RPS5 ribosomal protein S5 -2.76585
EXT1 exostosin glycosyltransferase 1 -2.72935
MKRN2 makorin ring finger protein 2 -2.6813
MAIP1 matrix AAA peptidase interacting protein 1 -2.6593
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.59265
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.59255
ZC3H7A zinc finger CCCH-type containing 7A -2.5683
NCK2 NCK adaptor protein 2 -2.5245
MVP major vault protein -2.5222
CCNH cyclin H -2.52215
PROS1 protein S (alpha) -2.50105
SQSTM1 sequestosome 1 -2.486
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) -2.4811
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.4757
NAP1L4 nucleosome assembly protein 1-like 4 -2.446
TOMM34 translocase of outer mitochondrial membrane 34 -2.4441
CD69 CD69 molecule -2.4368
CCNT1 cyclin T1 -2.4333
STOM stomatin -2.42665
PDHB pyruvate dehydrogenase (lipoamide) beta -2.4058
SEC13 SEC13 homolog (S. cerevisiae) -2.38785
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -2.37945
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.35888
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.34635
CTSL cathepsin L -2.33925
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -2.32775
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -2.32385
MRPL58 mitochondrial ribosomal protein L58 -2.3234
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.30253
MSX1 msh homeobox 1 -2.2903
CYB5A cytochrome b5 type A (microsomal) -2.26007
SLIT2 slit homolog 2 (Drosophila) -2.25765
ACTL6A actin-like 6A -2.25185
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.24585
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.24375
AXIN1 axin 1 -2.24275
GLT8D1 glycosyltransferase 8 domain containing 1 -2.24188
TM9SF2 transmembrane 9 superfamily member 2 -2.24115
KRT10 keratin 10, type I -2.23378
RPS8 ribosomal protein S8 -2.2323
DDB2 damage-specific DNA binding protein 2, 48kDa -2.22665
RHOA ras homolog family member A -2.19973
RGS2 regulator of G-protein signaling 2 -2.1795
BCL2L13 BCL2-like 13 (apoptosis facilitator) -2.15625
RBM6 RNA binding motif protein 6 -2.15465
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.14562
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.14505
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.1382
LHX6 LIM homeobox 6 -2.1362
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 -2.13335
MCM3 minichromosome maintenance complex component 3 -2.12765
CRBN cereblon -2.1222
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.117
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A -2.1155
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.10665
TPST2 tyrosylprotein sulfotransferase 2 -2.09525
STIL SCL/TAL1 interrupting locus -2.09055
FTL ferritin, light polypeptide -2.07525
CD58 CD58 molecule -2.07515
VGLL3 vestigial-like family member 3 -2.075
MYNN myoneurin -2.0679
TMEM204 transmembrane protein 204 -2.06615
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.05185
HLA-E major histocompatibility complex, class I, E -2.05005
RPN2 ribophorin II -2.04873
RWDD1 RWD domain containing 1 -2.0469
METTL22 methyltransferase like 22 -2.0467
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.0464
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.03375
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -2.026
RABL6 RAB, member RAS oncogene family-like 6 -2.02345
RPL10A ribosomal protein L10a -2.02325
DPH2 DPH2 homolog (S. cerevisiae) -2.0221
CERS6 ceramide synthase 6 -2.01732
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.01555
FCHSD2 FCH and double SH3 domains 2 -2.00705