| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 1,1,1-trichloroethane, technical grade 9.75 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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81 genes differentially expressed following the CRCGN008_HEPG2_24H:C09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STK10 | serine/threonine kinase 10 | 10.0 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 6.46295 |
| E2F2 | E2F transcription factor 2 | 5.2216 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 5.14175 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 4.74395 |
| GPER1 | G protein-coupled estrogen receptor 1 | 4.5952 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 4.51508 |
| NOTCH1 | notch 1 | 4.4064 |
| KAT6A | K(lysine) acetyltransferase 6A | 4.0941 |
| PLSCR3 | phospholipid scramblase 3 | 3.64475 |
| CYCS | cytochrome c, somatic | 3.1951 |
| ZBTB35 | zinc finger and BTB domain containing 35 | 3.1653 |
| PKN1 | protein kinase N1 | 2.9533 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.94445 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | 2.7523 |
| JADE2 | jade family PHD finger 2 | 2.74412 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 2.73572 |
| TBPL1 | TBP-like 1 | 2.58515 |
| ZNF492 | zinc finger protein 492 | 2.57395 |
| ADAT1 | adenosine deaminase, tRNA-specific 1 | 2.5694 |
| TAC4 | tachykinin 4 (hemokinin) | 2.4686 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 2.4526 |
| RNF139 | ring finger protein 139 | 2.4173 |
| GPHRA | golgi pH regulator A | 2.41418 |
| DMAC2L | distal membrane arm assembly component 2 like | 2.31588 |
| DDX43 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 | 2.3157 |
| SLC35B1 | solute carrier family 35, member B1 | 2.2962 |
| WASF3 | WAS protein family, member 3 | 2.2428 |
| CEP131 | centrosomal protein 131kDa | 2.19115 |
| TBP | TATA box binding protein | 2.19025 |
| DOCK6 | dedicator of cytokinesis 6 | 2.13937 |
| EVL | Enah/Vasp-like | 2.12695 |
| TMEM101 | transmembrane protein 101 | 2.12065 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 2.11492 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 2.09805 |
| POGLUT2 | protein O-glucosyltransferase 2 | 2.0959 |
| THAP12 | THAP domain containing 12 | 2.09485 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.08765 |
| SPARCL1 | SPARC-like 1 (hevin) | 2.0577 |
| RHBG | Rh family, B glycoprotein (gene/pseudogene) | 2.05 |
| REXO5 | RNA exonuclease 5 | 2.02835 |
| SF3A3 | splicing factor 3a, subunit 3, 60kDa | 2.02295 |
| RFXAP | regulatory factor X-associated protein | 2.0135 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | 2.0073 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -8.2872 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -5.7867 |
| WASHC4 | WASH complex subunit 4 | -5.34998 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -5.2026 |
| DERA | deoxyribose-phosphate aldolase (putative) | -5.14645 |
| PCNA | proliferating cell nuclear antigen | -5.0 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -4.8292 |
| CD58 | CD58 molecule | -4.44917 |
| SLC35F2 | solute carrier family 35, member F2 | -3.75135 |
| CCNB1 | cyclin B1 | -3.6077 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.53815 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.5111 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.48207 |
| RNF167 | ring finger protein 167 | -3.4396 |
| HSPA8 | heat shock 70kDa protein 8 | -2.86547 |
| SCAND1 | SCAN domain containing 1 | -2.627 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -2.50915 |
| MPST | mercaptopyruvate sulfurtransferase | -2.44785 |
| CD82 | CD82 molecule | -2.36835 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | -2.3449 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | -2.31265 |
| CD72 | CD72 molecule | -2.2963 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -2.2943 |
| RASAL1 | RAS protein activator like 1 (GAP1 like) | -2.2684 |
| CHST1 | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | -2.2192 |
| ABCF3 | ATP-binding cassette, sub-family F (GCN20), member 3 | -2.1801 |
| CLTB | clathrin, light chain B | -2.17674 |
| FBXO7 | F-box protein 7 | -2.15415 |
| BCL7A | B-cell CLL/lymphoma 7A | -2.09185 |
| PLXNB2 | plexin B2 | -2.0809 |
| CD9 | CD9 molecule | -2.07105 |
| TNFSF12-TNFSF13 | TNFSF12-TNFSF13 readthrough | -2.05065 |
| ZNF514 | zinc finger protein 514 | -2.0313 |
| LRRK1 | leucine-rich repeat kinase 1 | -2.0292 |
| IFT20 | intraflagellar transport 20 | -2.0285 |
| P2RX5 | purinergic receptor P2X, ligand gated ion channel, 5 | -2.0178 |
| NPY | neuropeptide Y | -2.0075 |
