| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 1,1,1-trichloroethane, technical grade 4.88 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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136 genes differentially expressed following the CRCGN008_HEPG2_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KLHL21 | kelch-like family member 21 | 5.2227 |
| ATP11B | ATPase, class VI, type 11B | 4.9701 |
| MAMLD1 | mastermind-like domain containing 1 | 4.94605 |
| NOTCH1 | notch 1 | 4.8612 |
| CCNA1 | cyclin A1 | 4.7905 |
| CCDC92 | coiled-coil domain containing 92 | 4.715 |
| MOK | MOK protein kinase | 4.70315 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.49355 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.40195 |
| GRWD1 | glutamate-rich WD repeat containing 1 | 3.75865 |
| HDGFL3 | HDGF like 3 | 3.65193 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.22125 |
| CYCS | cytochrome c, somatic | 3.20555 |
| PMM2 | phosphomannomutase 2 | 3.1294 |
| MAP7 | microtubule-associated protein 7 | 3.03282 |
| JADE2 | jade family PHD finger 2 | 2.82952 |
| CDC45 | cell division cycle 45 | 2.8009 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 2.76588 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.7608 |
| SFTPB | surfactant protein B | 2.75802 |
| TFCP2L1 | transcription factor CP2-like 1 | 2.6273 |
| CHN1 | chimerin 1 | 2.62325 |
| SRBD1 | S1 RNA binding domain 1 | 2.591 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.53877 |
| ATAD3A | ATPase family, AAA domain containing 3A | 2.5234 |
| GPATCH8 | G patch domain containing 8 | 2.45555 |
| ZNF593 | zinc finger protein 593 | 2.44575 |
| ADCYAP1 | adenylate cyclase activating polypeptide 1 (pituitary) | 2.4439 |
| CCNF | cyclin F | 2.41138 |
| DHDDS | dehydrodolichyl diphosphate synthase | 2.40957 |
| POU4F2 | POU class 4 homeobox 2 | 2.39815 |
| CCDC59 | coiled-coil domain containing 59 | 2.374 |
| PPA1 | pyrophosphatase (inorganic) 1 | 2.3615 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 2.34615 |
| SEMA6D | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D | 2.3423 |
| ZBTB24 | zinc finger and BTB domain containing 24 | 2.33965 |
| NOPCHAP1 | NOP protein chaperone 1 | 2.30625 |
| ARHGAP5 | Rho GTPase activating protein 5 | 2.2807 |
| MTERF3 | mitochondrial transcription termination factor 3 | 2.2555 |
| RIOX1 | ribosomal oxygenase 1 | 2.23565 |
| OR3A3 | olfactory receptor, family 3, subfamily A, member 3 | 2.21965 |
| IL22 | interleukin 22 | 2.20855 |
| PCBP3 | poly(rC) binding protein 3 | 2.19985 |
| POU3F1 | POU class 3 homeobox 1 | 2.19023 |
| CYP27B1 | cytochrome P450, family 27, subfamily B, polypeptide 1 | 2.1899 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 2.1898 |
| ZNF574 | zinc finger protein 574 | 2.18965 |
| PRMT3 | protein arginine methyltransferase 3 | 2.1876 |
| LGI2 | leucine-rich repeat LGI family, member 2 | 2.15745 |
| TASP1 | taspase, threonine aspartase, 1 | 2.15425 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 2.1527 |
| LAG3 | lymphocyte-activation gene 3 | 2.147 |
| NAV2 | neuron navigator 2 | 2.1464 |
| BCAS2 | breast carcinoma amplified sequence 2 | 2.1326 |
| GPR12 | G protein-coupled receptor 12 | 2.1317 |
| METTL13 | methyltransferase like 13 | 2.11218 |
| COL10A1 | collagen, type X, alpha 1 | 2.11013 |
| ASIC4 | acid sensing (proton gated) ion channel family member 4 | 2.11 |
| OR2S2 | olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) | 2.10005 |
| RNASEH2B | ribonuclease H2, subunit B | 2.0931 |
| IL21 | interleukin 21 | 2.08695 |
| ZNF589 | zinc finger protein 589 | 2.08345 |
| CLOCK | clock circadian regulator | 2.0697 |
| SHROOM2 | shroom family member 2 | 2.0665 |
| SLC35G2 | solute carrier family 35, member G2 | 2.05845 |
| GRM6 | glutamate receptor, metabotropic 6 | 2.0535 |
| PARVB | parvin, beta | 2.04647 |
| ZNF507 | zinc finger protein 507 | 2.02585 |
| IFNG | interferon, gamma | 2.02245 |
| IL12RB2 | interleukin 12 receptor, beta 2 | 2.01615 |
| PRKD3 | protein kinase D3 | 2.00052 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -10.0 |
| LDHD | lactate dehydrogenase D | -10.0 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -6.5242 |
| PUF60 | poly-U binding splicing factor 60KDa | -5.9618 |
| COG7 | component of oligomeric golgi complex 7 | -5.53615 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -5.1133 |
| PCNA | proliferating cell nuclear antigen | -4.77245 |
| CCNB2 | cyclin B2 | -4.7503 |
| DNM1L | dynamin 1-like | -4.74065 |
| NUP85 | nucleoporin 85kDa | -4.56475 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -4.53435 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -4.23165 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -4.14285 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.8205 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -3.5414 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -3.10795 |
| MRPS7 | mitochondrial ribosomal protein S7 | -3.08475 |
| TLCD3A | TLC domain containing 3A | -3.08065 |
| SNX17 | sorting nexin 17 | -3.03475 |
| SCRIB | scribbled planar cell polarity protein | -2.9613 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | -2.68035 |
| CFI | complement factor I | -2.6685 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.66832 |
| DTD1 | D-tyrosyl-tRNA deacylase 1 | -2.65655 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -2.57327 |
| VTI1B | vesicle transport through interaction with t-SNAREs 1B | -2.5712 |
| TOR1A | torsin family 1, member A (torsin A) | -2.49555 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -2.48313 |
| FDXR | ferredoxin reductase | -2.45435 |
| RNF167 | ring finger protein 167 | -2.4423 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | -2.43465 |
| TRAPPC11 | trafficking protein particle complex 11 | -2.42925 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -2.4156 |
| SLC9B2 | solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 | -2.3524 |
| DENND3 | DENN/MADD domain containing 3 | -2.34938 |
| MILR1 | mast cell immunoglobulin-like receptor 1 | -2.3391 |
| MYF6 | myogenic factor 6 (herculin) | -2.3287 |
| ANKRD11 | ankyrin repeat domain 11 | -2.3166 |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) | -2.28525 |
| GATB | glutamyl-tRNA(Gln) amidotransferase, subunit B | -2.2704 |
| TBXAS1 | thromboxane A synthase 1 (platelet) | -2.2463 |
| WDR26 | WD repeat domain 26 | -2.24565 |
| PALB2 | partner and localizer of BRCA2 | -2.22605 |
| DES | desmin | -2.21213 |
| LMBR1L | limb development membrane protein 1-like | -2.16105 |
| ZNF274 | zinc finger protein 274 | -2.13285 |
| ZNF7 | zinc finger protein 7 | -2.131 |
| POLR2J3 | polymerase (RNA) II (DNA directed) polypeptide J3 | -2.12847 |
| CSRP2 | cysteine and glycine-rich protein 2 | -2.12598 |
| PPFIA2 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 | -2.11985 |
| AKTIP | AKT interacting protein | -2.11755 |
| DZIP1 | DAZ interacting zinc finger protein 1 | -2.09177 |
| PHYHIP | phytanoyl-CoA 2-hydroxylase interacting protein | -2.0624 |
| TMEM230 | transmembrane protein 230 | -2.0571 |
| NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase | -2.04845 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -2.04695 |
| PAMR1 | peptidase domain containing associated with muscle regeneration 1 | -2.0428 |
| JPT1 | Jupiter microtubule associated homolog 1 | -2.0393 |
| TNNI2 | troponin I type 2 (skeletal, fast) | -2.0355 |
| NRBP1 | nuclear receptor binding protein 1 | -2.02565 |
| FLNC | filamin C, gamma | -2.0236 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | -2.0224 |
| DOLK | dolichol kinase | -2.022 |
| TNNI1 | troponin I type 1 (skeletal, slow) | -2.0202 |
| TMEM94 | transmembrane protein 94 | -2.00365 |
