| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 1,1,1-trichloroethane, technical grade 1.22 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
| Downloads & Tools |
94 genes differentially expressed following the CRCGN008_HEPG2_24H:C12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBQLN2 | ubiquilin 2 | 5.17325 |
| ATP11B | ATPase, class VI, type 11B | 5.17085 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.1128 |
| NOTCH1 | notch 1 | 5.0225 |
| ADRB2 | adrenoceptor beta 2, surface | 4.96705 |
| HOXA10 | homeobox A10 | 4.93637 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 4.90415 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 4.16035 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 3.94285 |
| EGF | epidermal growth factor | 3.80535 |
| ABHD4 | abhydrolase domain containing 4 | 3.5243 |
| CYCS | cytochrome c, somatic | 3.42005 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.27735 |
| STIMATE | STIM activating enhancer | 3.16555 |
| CENPM | centromere protein M | 3.11705 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 3.05417 |
| CHEK2 | checkpoint kinase 2 | 2.78145 |
| GATA2 | GATA binding protein 2 | 2.72498 |
| PMM2 | phosphomannomutase 2 | 2.64855 |
| CHN1 | chimerin 1 | 2.49265 |
| HOXA10-HOXA9 | HOXA10-HOXA9 readthrough | 2.47228 |
| DDTL | D-dopachrome tautomerase-like | 2.4096 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 2.37685 |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | 2.3309 |
| MAST2 | microtubule associated serine/threonine kinase 2 | 2.29795 |
| UFM1 | ubiquitin-fold modifier 1 | 2.27485 |
| CEP57 | centrosomal protein 57kDa | 2.25867 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | 2.24255 |
| TMEM106C | transmembrane protein 106C | 2.2263 |
| MCMBP | minichromosome maintenance complex binding protein | 2.2062 |
| RPAP3 | RNA polymerase II associated protein 3 | 2.20255 |
| METRN | meteorin, glial cell differentiation regulator | 2.13665 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.1315 |
| BIRC2 | baculoviral IAP repeat containing 2 | 2.1057 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 2.096 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 2.0815 |
| UBXN8 | UBX domain protein 8 | 2.0745 |
| SLAMF7 | SLAM family member 7 | 2.0614 |
| OSR2 | odd-skipped related transciption factor 2 | 2.0557 |
| LYSET | lysosomal enzyme trafficking factor | 2.01985 |
| UBE2J1 | ubiquitin-conjugating enzyme E2, J1 | 2.00746 |
| SUMF2 | sulfatase modifying factor 2 | 2.00085 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GNAS | GNAS complex locus | -7.7425 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -5.14345 |
| GOLT1B | golgi transport 1B | -5.0539 |
| CCDC86 | coiled-coil domain containing 86 | -4.94295 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -4.9063 |
| PCNA | proliferating cell nuclear antigen | -4.81965 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -4.7862 |
| LDHD | lactate dehydrogenase D | -4.5593 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -4.4538 |
| FASTKD5 | FAST kinase domains 5 | -4.3876 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -4.3316 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.8051 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.0455 |
| DDIT4 | DNA-damage-inducible transcript 4 | -3.0145 |
| HSPA4 | heat shock 70kDa protein 4 | -2.77383 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | -2.70273 |
| SCG3 | secretogranin III | -2.57985 |
| IDH3B | isocitrate dehydrogenase 3 (NAD+) beta | -2.52717 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -2.51375 |
| MAGEA9B | melanoma antigen family A9B | -2.4873 |
| SOX12 | SRY (sex determining region Y)-box 12 | -2.4834 |
| NOL4 | nucleolar protein 4 | -2.42795 |
| PLIN2 | perilipin 2 | -2.39455 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -2.36235 |
| EXT1 | exostosin glycosyltransferase 1 | -2.33827 |
| DDX25 | DEAD (Asp-Glu-Ala-Asp) box helicase 25 | -2.32225 |
| AADAC | arylacetamide deacetylase | -2.3145 |
| DOK5 | docking protein 5 | -2.30495 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -2.29995 |
| UBC | ubiquitin C | -2.25973 |
| KRT7 | keratin 7, type II | -2.22215 |
| CMTM6 | CKLF-like MARVEL transmembrane domain containing 6 | -2.21155 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -2.20595 |
| RBM34 | RNA binding motif protein 34 | -2.18027 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -2.1798 |
| GLOD4 | glyoxalase domain containing 4 | -2.158 |
| LZTS3 | leucine zipper, putative tumor suppressor family member 3 | -2.157 |
| CCDC102B | coiled-coil domain containing 102B | -2.15095 |
| RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | -2.14762 |
| RPL38 | ribosomal protein L38 | -2.1387 |
| AQP4 | aquaporin 4 | -2.11879 |
| ACTG1 | actin gamma 1 | -2.09305 |
| DDRGK1 | DDRGK domain containing 1 | -2.08295 |
| ANGPTL4 | angiopoietin-like 4 | -2.0664 |
| RPL19 | ribosomal protein L19 | -2.0618 |
| ZNF107 | zinc finger protein 107 | -2.03625 |
| DCTN4 | dynactin 4 (p62) | -2.02755 |
| CNKSR3 | CNKSR family member 3 | -2.0261 |
| NPTX1 | neuronal pentraxin I | -2.01905 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -2.0152 |
| SAGE1 | sarcoma antigen 1 | -2.0062 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | -2.00465 |
