CRCGN008_HEPG2_24H:C15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bromodichloromethane 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

99 genes differentially expressed following the CRCGN008_HEPG2_24H:C15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 7.45675
E2F2 E2F transcription factor 2 5.4067
CARMIL1 capping protein regulator and myosin 1 linker 1 5.18815
AMDHD2 amidohydrolase domain containing 2 4.9759
HOXA10 homeobox A10 4.93962
SMIM40 small integral membrane protein 40 4.92095
ATP11B ATPase, class VI, type 11B 4.9012
EGF epidermal growth factor 3.9668
PRR15L proline rich 15-like 3.82345
CCL2 chemokine (C-C motif) ligand 2 3.65385
MAP7 microtubule-associated protein 7 3.64377
ANO1 anoctamin 1, calcium activated chloride channel 3.32995
CDCA4 cell division cycle associated 4 3.1739
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.9738
HLA-DRA major histocompatibility complex, class II, DR alpha 2.93973
EPHA3 EPH receptor A3 2.91685
CCNF cyclin F 2.77203
CPNE2 copine II 2.64785
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.63517
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.6204
JADE2 jade family PHD finger 2 2.59002
ECH1 enoyl CoA hydratase 1, peroxisomal 2.5752
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.52453
ADGRA2 adhesion G protein-coupled receptor A2 2.4572
RNF32 ring finger protein 32 2.3939
ECT2 epithelial cell transforming 2 2.39205
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 2.32708
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.30485
BTNL3 butyrophilin-like 3 2.2742
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.26699
CENPS-CORT CENPS-CORT readthrough 2.2534
PPP1R2C PPP1R2C family member C 2.247
CD1D CD1d molecule 2.21195
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 2.18525
DDAH1 dimethylarginine dimethylaminohydrolase 1 2.18425
HPSE2 heparanase 2 (inactive) 2.18085
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.17575
ZNF189 zinc finger protein 189 2.17045
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.1628
ONECUT2 one cut homeobox 2 2.15375
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 2.1455
DNMBP dynamin binding protein 2.1434
NDNF neuron-derived neurotrophic factor 2.0904
TUBAL3 tubulin, alpha-like 3 2.0759
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.0749
CEP152 centrosomal protein 152kDa 2.07433
DNASE1L3 deoxyribonuclease I-like 3 2.07225
SPATA31C1 SPATA31 subfamily C, member 1 2.0576
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.0539
GPN2 GPN-loop GTPase 2 2.0516
NBPF3 neuroblastoma breakpoint family, member 3 2.03695
APOC3 apolipoprotein C-III 2.03335
KNG1 kininogen 1 2.02448
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.02442
KIF20A kinesin family member 20A 2.0244
ARID3B AT rich interactive domain 3B (BRIGHT-like) 2.0209
SLC30A10 solute carrier family 30, member 10 2.0188
PRM2 protamine 2 2.01095
CCDC85C coiled-coil domain containing 85C 2.0108
HEPH hephaestin 2.0041
YBX2 Y box binding protein 2 2.0018

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.83295
DNM1L dynamin 1-like -5.50935
LDHD lactate dehydrogenase D -5.282
FASTKD5 FAST kinase domains 5 -5.2005
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.92165
TLCD3A TLC domain containing 3A -4.88235
ADI1 acireductone dioxygenase 1 -4.67875
TWF2 twinfilin actin binding protein 2 -4.53375
HLA-DMA major histocompatibility complex, class II, DM alpha -4.52675
RNF167 ring finger protein 167 -3.41995
DDRGK1 DDRGK domain containing 1 -3.3213
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.03417
PECR peroxisomal trans-2-enoyl-CoA reductase -2.7968
TMEM230 transmembrane protein 230 -2.7604
DERA deoxyribose-phosphate aldolase (putative) -2.73715
NSFL1C NSFL1 (p97) cofactor (p47) -2.71047
TXNDC9 thioredoxin domain containing 9 -2.70932
CLTB clathrin, light chain B -2.55008
PTPRM protein tyrosine phosphatase, receptor type, M -2.5415
MAVS mitochondrial antiviral signaling protein -2.50725
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.40615
HSPA8 heat shock 70kDa protein 8 -2.38467
NRIP1 nuclear receptor interacting protein 1 -2.34783
CSNK2A2 casein kinase 2, alpha prime polypeptide -2.30628
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.29875
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.28415
DUSP14 dual specificity phosphatase 14 -2.27675
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.26585
NOP56 NOP56 ribonucleoprotein -2.2586
FKBP1C FK506 binding protein 1C -2.25038
CD9 CD9 molecule -2.2247
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.22155
IFRD2 interferon-related developmental regulator 2 -2.18847
WWC2 WW and C2 domain containing 2 -2.11175
BTG3 BTG family, member 3 -2.09987
METTL18 methyltransferase like 18 -2.09105
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.05165