CRCGN008_HEPG2_24H:C16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bromodichloromethane 5.03 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN008_HEPG2_24H:C16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.23615
TATDN2 TatD DNase domain containing 2 5.1215
MYLK myosin light chain kinase 4.96485
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.90365
KLHL9 kelch-like family member 9 4.89777
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.80975
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.5283
BACE2 beta-site APP-cleaving enzyme 2 4.467
HOXA10 homeobox A10 4.39187
CXCR4 chemokine (C-X-C motif) receptor 4 4.16795
PLSCR1 phospholipid scramblase 1 3.716
CHN1 chimerin 1 3.57235
PEX11A peroxisomal biogenesis factor 11 alpha 3.4642
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.337
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.17588
GPATCH8 G patch domain containing 8 3.09225
TIAM1 T-cell lymphoma invasion and metastasis 1 3.04565
CYCS cytochrome c, somatic 2.5959
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.5044
VGLL4 vestigial-like family member 4 2.47593
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.46825
TBP TATA box binding protein 2.4303
JADE2 jade family PHD finger 2 2.42567
CEP57 centrosomal protein 57kDa 2.41655
ADAT1 adenosine deaminase, tRNA-specific 1 2.35225
UFM1 ubiquitin-fold modifier 1 2.21305
BPHL biphenyl hydrolase-like (serine hydrolase) 2.2007
MMD monocyte to macrophage differentiation-associated 2.13795
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.08941
MKRN2 makorin ring finger protein 2 2.07445
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 2.0416
KIF20A kinesin family member 20A 2.04155
PDF peptide deformylase (mitochondrial) 2.00945

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -5.08135
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.0614
SLC35F2 solute carrier family 35, member F2 -4.9809
CCNB2 cyclin B2 -4.70205
CDC20 cell division cycle 20 -4.6933
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.05995
RBM15B RNA binding motif protein 15B -3.98715
DCK deoxycytidine kinase -3.55595
CTNND1 catenin (cadherin-associated protein), delta 1 -3.11213
CCNB1 cyclin B1 -2.8086
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.80625
OXA1L oxidase (cytochrome c) assembly 1-like -2.65695
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.57135
RNF167 ring finger protein 167 -2.53345
CLIC2 chloride intracellular channel 2 -2.4585
FHL2 four and a half LIM domains 2 -2.29695
GUCA2B guanylate cyclase activator 2B (uroguanylin) -2.27285
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1786
FNBP4 formin binding protein 4 -2.17345
ATF5 activating transcription factor 5 -2.16465
ADA adenosine deaminase -2.12695
RNF146 ring finger protein 146 -2.1039
RAB40C RAB40C, member RAS oncogene family -2.02805
RBM6 RNA binding motif protein 6 -2.0225