CRCGN008_HEPG2_24H:C17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bromodichloromethane 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

164 genes differentially expressed following the CRCGN008_HEPG2_24H:C17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRR15L proline rich 15-like 9.48205
ADRB2 adrenoceptor beta 2, surface 5.90395
CARMIL1 capping protein regulator and myosin 1 linker 1 5.27325
STK10 serine/threonine kinase 10 4.8694
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.8543
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.84555
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.83165
UBQLN2 ubiquilin 2 4.7495
MYLK myosin light chain kinase 4.7409
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.59855
PLSCR1 phospholipid scramblase 1 4.33785
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.33744
FCHO1 FCH domain only 1 4.33175
PPARG peroxisome proliferator-activated receptor gamma 4.07355
MAP7 microtubule-associated protein 7 3.73592
BRCA1 breast cancer 1, early onset 3.36595
GATA3 GATA binding protein 3 3.24837
GPATCH8 G patch domain containing 8 3.07078
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 3.0681
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.04857
DHDDS dehydrodolichyl diphosphate synthase 3.02167
EBF2 early B-cell factor 2 2.9406
NKAPD1 NKAP domain containing 1 2.74905
H2AC7 H2A clustered histone 7 2.73915
RPL39L ribosomal protein L39-like 2.6661
CA4 carbonic anhydrase IV 2.61935
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.5439
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.5408
CLCN6 chloride channel, voltage-sensitive 6 2.53385
SAP30BP SAP30 binding protein 2.50925
UBE4A ubiquitination factor E4A 2.5083
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.46145
TBP TATA box binding protein 2.4447
CHEK2 checkpoint kinase 2 2.40825
SHARPIN SHANK-associated RH domain interactor 2.3823
PAIP2B poly(A) binding protein interacting protein 2B 2.37885
RELN reelin 2.37395
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.34785
HROB homologous recombination factor with OB-fold 2.34455
CCNK cyclin K 2.326
ZC3H4 zinc finger CCCH-type containing 4 2.32565
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 2.3062
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.2929
SFTPB surfactant protein B 2.2925
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.29145
TMED3 transmembrane emp24 protein transport domain containing 3 2.2848
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.2717
MIS18A MIS18 kinetochore protein A 2.25495
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 2.25415
COPS5 COP9 signalosome subunit 5 2.2528
MOAP1 modulator of apoptosis 1 2.2466
CDH5 cadherin 5, type 2 (vascular endothelium) 2.24475
GUCA2A guanylate cyclase activator 2A (guanylin) 2.2409
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 2.2372
ANO10 anoctamin 10 2.2354
LOC124900193 uncharacterized LOC124900193 2.2236
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.21755
NSD1 nuclear receptor binding SET domain protein 1 2.2169
NBPF3 neuroblastoma breakpoint family, member 3 2.2136
KIF18A kinesin family member 18A 2.2014
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.19195
PRPF3 pre-mRNA processing factor 3 2.18955
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 2.18365
GCG glucagon 2.17975
ZFYVE16 zinc finger, FYVE domain containing 16 2.17615
APH1A APH1A gamma secretase subunit 2.1603
MTA2 metastasis associated 1 family, member 2 2.1541
MAST3 microtubule associated serine/threonine kinase 3 2.13425
OXCT1 3-oxoacid CoA transferase 1 2.13325
RPIA ribose 5-phosphate isomerase A 2.11755
NOSIP nitric oxide synthase interacting protein 2.1168
SBNO1 strawberry notch homolog 1 (Drosophila) 2.11265
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.1104
DGAT1 diacylglycerol O-acyltransferase 1 2.104
ELAVL2 ELAV like neuron-specific RNA binding protein 2 2.0977
PCF11 PCF11 cleavage and polyadenylation factor subunit 2.0896
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 2.0888
UFM1 ubiquitin-fold modifier 1 2.0695
VWF von Willebrand factor 2.068
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.06245
GAL3ST1 galactose-3-O-sulfotransferase 1 2.06065
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.0509
HTN3 histatin 3 2.04695
BET1L Bet1 golgi vesicular membrane trafficking protein-like 2.0407
PXDNL peroxidasin-like 2.03425
CRY2 cryptochrome circadian clock 2 2.03305
GPC3 glypican 3 2.03135
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.0268
TMSB10 thymosin beta 10 2.0251
TWNK twinkle mtDNA helicase 2.0202
SLC44A1 solute carrier family 44 (choline transporter), member 1 2.01865
CCNDBP1 cyclin D-type binding-protein 1 2.0117
GGTLC1 gamma-glutamyltransferase light chain 1 2.0116
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.00567

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
TLCD3A TLC domain containing 3A -10.0
UBE3C ubiquitin protein ligase E3C -5.7808
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.42715
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -5.37818
ZNF586 zinc finger protein 586 -5.33415
CCDC86 coiled-coil domain containing 86 -5.1665
FAIM Fas apoptotic inhibitory molecule -5.1249
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.121
LDHD lactate dehydrogenase D -5.08075
RPN1 ribophorin I -5.06005
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.0
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.8755
DSG2 desmoglein 2 -4.77845
ADI1 acireductone dioxygenase 1 -4.53125
CDC20 cell division cycle 20 -4.3123
NGRN neugrin, neurite outgrowth associated -4.0092
SPAG4 sperm associated antigen 4 -3.8027
TWF2 twinfilin actin binding protein 2 -3.52455
RGS2 regulator of G-protein signaling 2 -3.2868
PGM1 phosphoglucomutase 1 -3.27435
HLA-DMA major histocompatibility complex, class II, DM alpha -3.18805
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.0823
PRPF19 pre-mRNA processing factor 19 -3.05255
RFC2 replication factor C (activator 1) 2, 40kDa -2.80535
CHIC2 cysteine-rich hydrophobic domain 2 -2.71635
ACAA1 acetyl-CoA acyltransferase 1 -2.601
MSRA methionine sulfoxide reductase A -2.5979
ACOT9 acyl-CoA thioesterase 9 -2.58525
TXNDC9 thioredoxin domain containing 9 -2.5606
HMG20B high mobility group 20B -2.5517
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.5141
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -2.49535
GRAMD2B GRAM domain containing 2B -2.4609
CAPNS1 calpain, small subunit 1 -2.4091
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -2.3916
PEX12 peroxisomal biogenesis factor 12 -2.3783
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 -2.355
BTG3 BTG family, member 3 -2.3467
RANBP9 RAN binding protein 9 -2.32222
GDI1 GDP dissociation inhibitor 1 -2.3197
MAGEC2 melanoma antigen family C2 -2.3146
KIFBP kinesin family binding protein -2.30405
SUSD5 sushi domain containing 5 -2.2918
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.26307
KRT18 keratin 18, type I -2.25215
LOC124907782 dual specificity protein phosphatase 22 -2.2434
STIP1 stress-induced phosphoprotein 1 -2.23815
DSTN destrin (actin depolymerizing factor) -2.2147
GNAS GNAS complex locus -2.19161
BAG2 BCL2-associated athanogene 2 -2.1838
IL2RB interleukin 2 receptor, beta -2.15445
TWSG1 twisted gastrulation BMP signaling modulator 1 -2.1531
ZNF587B zinc finger protein 587B -2.14885
PARP3 poly (ADP-ribose) polymerase family, member 3 -2.1453
MCM6 minichromosome maintenance complex component 6 -2.14415
ZBED2 zinc finger, BED-type containing 2 -2.1186
UBE2S ubiquitin-conjugating enzyme E2S -2.1013
ICOS inducible T-cell co-stimulator -2.09555
CCNB1 cyclin B1 -2.09285
RETREG1 reticulophagy regulator 1 -2.08597
GPRASP1 G protein-coupled receptor associated sorting protein 1 -2.0811
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.08085
ZNF571 zinc finger protein 571 -2.0807
LRRN2 leucine rich repeat neuronal 2 -2.0756
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) -2.06682
COPS7A COP9 signalosome subunit 7A -2.0614
TRIM23 tripartite motif containing 23 -2.04413
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) -2.04115
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -2.00665