CRCGN008_HEPG2_24H:C18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bromodichloromethane 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

87 genes differentially expressed following the CRCGN008_HEPG2_24H:C18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
STK10 serine/threonine kinase 10 10.0
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.16915
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.6775
C2CD2 C2 calcium-dependent domain containing 2 4.96565
PRR15L proline rich 15-like 4.66495
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.2942
CCDC85B coiled-coil domain containing 85B 3.7812
SHB Src homology 2 domain containing adaptor protein B 3.35927
SNX7 sorting nexin 7 3.1693
CHN1 chimerin 1 3.14025
TIAM1 T-cell lymphoma invasion and metastasis 1 3.06677
SOCS2 suppressor of cytokine signaling 2 2.76737
BIRC2 baculoviral IAP repeat containing 2 2.6829
NMU neuromedin U 2.64745
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.4702
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.39065
RPL26L1 ribosomal protein L26-like 1 2.36355
MYO1F myosin IF 2.36275
ADAT1 adenosine deaminase, tRNA-specific 1 2.35965
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 2.3535
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.2277
TLR4 toll-like receptor 4 2.18095
CD36 CD36 molecule (thrombospondin receptor) 2.18075
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.16365
LPL lipoprotein lipase 2.11713
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.11355
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.08465
RNPS1 RNA binding protein S1, serine-rich domain 2.07457
CES3 carboxylesterase 3 2.0529
HEG1 heart development protein with EGF-like domains 1 2.01417

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -7.07925
OXA1L oxidase (cytochrome c) assembly 1-like -5.6789
ADI1 acireductone dioxygenase 1 -5.4077
WASHC4 WASH complex subunit 4 -5.30597
NRIP1 nuclear receptor interacting protein 1 -5.29752
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.92165
PDHX pyruvate dehydrogenase complex, component X -3.83737
PRPF4 pre-mRNA processing factor 4 -3.4478
TRAPPC6A trafficking protein particle complex 6A -3.0227
ANKRD10 ankyrin repeat domain 10 -2.973
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.85825
ABITRAM actin binding transcription modulator -2.83805
GIN1 gypsy retrotransposon integrase 1 -2.78385
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.6921
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -2.58645
WASF1 WAS protein family, member 1 -2.5584
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.47515
IFT22 intraflagellar transport 22 -2.4605
GPR143 G protein-coupled receptor 143 -2.3542
GLI1 GLI family zinc finger 1 -2.3188
CAPRIN1 cell cycle associated protein 1 -2.31082
GLRB glycine receptor, beta -2.3108
PGR progesterone receptor -2.2546
TM9SF3 transmembrane 9 superfamily member 3 -2.2265
IRF2BP1 interferon regulatory factor 2 binding protein 1 -2.2116
DEPTOR DEP domain containing MTOR-interacting protein -2.2088
TXNDC9 thioredoxin domain containing 9 -2.2077
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 -2.19395
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 -2.19045
APH1A APH1A gamma secretase subunit -2.19015
SF3B4 splicing factor 3b, subunit 4, 49kDa -2.18565
COMMD9 COMM domain containing 9 -2.14855
NAT10 N-acetyltransferase 10 (GCN5-related) -2.14045
CCNC cyclin C -2.12085
KRT76 keratin 76, type II -2.1127
LHFPL2 lipoma HMGIC fusion partner-like 2 -2.1127
OLA1 Obg-like ATPase 1 -2.10835
MIMS2 mitochondrial inner membrane scaffold 2 -2.10365
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -2.09728
GBP2 guanylate binding protein 2, interferon-inducible -2.09485
PYGO1 pygopus family PHD finger 1 -2.0754
ACAA1 acetyl-CoA acyltransferase 1 -2.07498
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -2.0721
THAP1 THAP domain containing, apoptosis associated protein 1 -2.0658
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.0521
ORC4 origin recognition complex, subunit 4 -2.0445
MAG myelin associated glycoprotein -2.042
CD2AP CD2-associated protein -2.0399
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.0265
CFAP69 cilia and flagella associated protein 69 -2.0237
RTL10 retrotransposon Gag like 10 -2.0156
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 -2.00575
NAV3 neuron navigator 3 -2.00495
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.0031
CCDC85C coiled-coil domain containing 85C -2.0009