CRCGN008_HEPG2_24H:D02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phosphonium sulfate 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

133 genes differentially expressed following the CRCGN008_HEPG2_24H:D02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BACE2 beta-site APP-cleaving enzyme 2 6.5363
VGLL4 vestigial-like family member 4 6.43685
CHN1 chimerin 1 6.36535
C2CD2 C2 calcium-dependent domain containing 2 5.8205
ADRB2 adrenoceptor beta 2, surface 5.38945
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.3493
ATP11B ATPase, class VI, type 11B 5.34075
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.79395
HLA-DMA major histocompatibility complex, class II, DM alpha 4.5708
NOTCH1 notch 1 4.52695
STK10 serine/threonine kinase 10 4.19785
ABHD6 abhydrolase domain containing 6 4.16477
SSBP2 single-stranded DNA binding protein 2 3.99355
CDC45 cell division cycle 45 3.91445
TXNRD1 thioredoxin reductase 1 3.29415
UGDH UDP-glucose 6-dehydrogenase 3.1503
PRR15L proline rich 15-like 3.1444
ABHD4 abhydrolase domain containing 4 2.89805
JADE2 jade family PHD finger 2 2.80795
CCNF cyclin F 2.6702
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.65805
TBP TATA box binding protein 2.63555
ZNF589 zinc finger protein 589 2.62663
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.6238
CNPY3 canopy FGF signaling regulator 3 2.6201
GPATCH8 G patch domain containing 8 2.61775
LPAR2 lysophosphatidic acid receptor 2 2.61445
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.59615
CCP110 centriolar coiled coil protein 110kDa 2.4668
DHRS1 dehydrogenase/reductase (SDR family) member 1 2.44155
TXNL4B thioredoxin-like 4B 2.3935
CREB1 cAMP responsive element binding protein 1 2.36547
SCFD1 sec1 family domain containing 1 2.33155
KLHL9 kelch-like family member 9 2.27515
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.2729
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.2567
SIRT3 sirtuin 3 2.18983
RNF130 ring finger protein 130 2.18285
CYCS cytochrome c, somatic 2.18045
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.17138
KIF20A kinesin family member 20A 2.1453
APOM apolipoprotein M 2.12337
NMU neuromedin U 2.11325
STAP2 signal transducing adaptor family member 2 2.08945
CD99 CD99 molecule 2.08265
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 2.08185
FAM117A family with sequence similarity 117, member A 2.0794
ANG angiogenin, ribonuclease, RNase A family, 5 2.0765
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.0572
GJB1 gap junction protein, beta 1, 32kDa 2.05635
MARCHF7 membrane associated ring-CH-type finger 7 2.05345
GALE UDP-galactose-4-epimerase 2.04815
TAC4 tachykinin 4 (hemokinin) 2.03995
FMO5 flavin containing monooxygenase 5 2.03653
XPC xeroderma pigmentosum, complementation group C 2.0298
KRT5 keratin 5, type II 2.0035
NOSIP nitric oxide synthase interacting protein 2.0034

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
LDHD lactate dehydrogenase D -10.0
NGRN neugrin, neurite outgrowth associated -6.20205
CD320 CD320 molecule -5.976
TLCD3A TLC domain containing 3A -5.506
ZNF586 zinc finger protein 586 -5.32295
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.26245
RPIA ribose 5-phosphate isomerase A -5.17435
CCNB2 cyclin B2 -4.52935
LOC124907782 dual specificity protein phosphatase 22 -4.2202
FASTKD5 FAST kinase domains 5 -4.16895
FGFR4 fibroblast growth factor receptor 4 -4.1568
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.6814
SPAG4 sperm associated antigen 4 -3.3874
MAPK13 mitogen-activated protein kinase 13 -3.29052
CCNB1 cyclin B1 -3.0969
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.0939
ZNF274 zinc finger protein 274 -3.0118
SCAND1 SCAN domain containing 1 -2.8657
LSM1 LSM1, U6 small nuclear RNA associated -2.72205
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.70537
ZNF304 zinc finger protein 304 -2.698
ZNF134 zinc finger protein 134 -2.66855
TXNDC9 thioredoxin domain containing 9 -2.57715
CCRL2 chemokine (C-C motif) receptor-like 2 -2.57615
GRIA4 glutamate receptor, ionotropic, AMPA 4 -2.519
ZNF606 zinc finger protein 606 -2.48555
IL18R1 interleukin 18 receptor 1 -2.464
GCC1 GRIP and coiled-coil domain containing 1 -2.45645
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.43465
NXT1 nuclear transport factor 2-like export factor 1 -2.3199
RAI14 retinoic acid induced 14 -2.27355
ZNF343 zinc finger protein 343 -2.26715
TNIP3 TNFAIP3 interacting protein 3 -2.2633
LDB3 LIM domain binding 3 -2.25822
LAMA5 laminin, alpha 5 -2.2443
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 -2.24065
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) -2.2302
BMP4 bone morphogenetic protein 4 -2.2299
PGAM2 phosphoglycerate mutase 2 (muscle) -2.22935
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -2.22795
DGKI diacylglycerol kinase, iota -2.223
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.20463
CASQ2 calsequestrin 2 (cardiac muscle) -2.18605
MRPL48 mitochondrial ribosomal protein L48 -2.15365
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -2.14955
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.14935
TMC7 transmembrane channel-like 7 -2.1434
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -2.14275
MYOM1 myomesin 1 -2.14255
CDC25B cell division cycle 25B -2.1298
THSD4 thrombospondin, type I, domain containing 4 -2.11785
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.11565
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 -2.1089
CD200R1 CD200 receptor 1 -2.1054
THAP1 THAP domain containing, apoptosis associated protein 1 -2.1049
DEFA3 defensin, alpha 3, neutrophil-specific -2.1012
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.09255
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.08575
LMF1 lipase maturation factor 1 -2.066
PANK2 pantothenate kinase 2 -2.06355
PTPRR protein tyrosine phosphatase, receptor type, R -2.0612
HCLS1 hematopoietic cell-specific Lyn substrate 1 -2.0578
MAVS mitochondrial antiviral signaling protein -2.0489
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -2.0486
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -2.0479
PMP2 peripheral myelin protein 2 -2.0478
SCN1B sodium channel, voltage gated, type I beta subunit -2.04645
FICD FIC domain containing -2.03445
TUBB6 tubulin, beta 6 class V -2.02505
CCL7 chemokine (C-C motif) ligand 7 -2.02375
HDAC6 histone deacetylase 6 -2.02257
ZNF551 zinc finger protein 551 -2.01255
ZNF778 zinc finger protein 778 -2.0074
SFT2D2 SFT2 domain containing 2 -2.00235
DEFA4 defensin, alpha 4, corticostatin -2.0013